1.Delayed Terminal Ileal Perforation in a Relapsed/Refractory B-Cell Lymphoma Patient with Rapid Remission Following Chimeric Antigen Receptor T-Cell Therapy.
Yongxian HU ; Jiasheng WANG ; Chengfei PU ; Kui ZHAO ; Qu CUI ; Guoqing WEI ; Wenjun WU ; Lei XIAO ; Yang XIAO ; Jinping WANG ; Zhao WU ; He HUANG
Cancer Research and Treatment 2018;50(4):1462-1466
Chimeric antigen receptor T-cell strategy targeting CD19 (CART19) has prominent anti-tumor effect for relapsed/refractory B-cell lymphomas. CART19-associated complications have been gradually recognized, however, late-onset complications have not been extensively studied. Herein, for the first time we report a diffuse large B-cell lymphoma patient with terminal ileum involvement obtained rapid remission and developed spontaneous terminal ileal perforation 38 days following CART19 infusion. The late-onset perforation reminds us that, for the safety of CART treatment, more cautions are warranted for the management of delayed GI complications.
B-Lymphocytes*
;
Humans
;
Ileum
;
Lymphoma, B-Cell*
;
Receptors, Antigen*
;
T-Lymphocytes*
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