Neuropathic pain is a kind of chronic pain caused by nervous system injury. Because of its complex mechanism, the treatment of neuropathic pain is still a major challenge to health problems all over the world. Recent studies have shown that autophagy dysfunction is the pathophysiological basis for the occurrence and development of neuropathic pain, and neuropathic pain can be alleviated by regulating autophagy. Based on the mechanism of autophagy and neuropathic pain, this paper reviews the drugs that regulate autophagy in the treatment of neuro-pathic pain, in order to provide reference for the drug treatment of this disease.