Objective To observe the early clinical efficacy of PFC fixed platform and RP rotating platform prosthesis two kinds of artificial knee replacement system for the treatment of knee osteoarthritis.Methods 39 cases (39 knees)with knee osteoarthritis were treated with total knee arthroplasty(TKA).According to intraoperative use of different types of prosthesis,the cases were divided into two groups:fixed platforms group 16 cases and rotating platform group 23 cases.The wound healing,patients with gait and knee activity after operation were observed.Results Three cases took place postoperative deep vein thrombosis,after conservative treatment,the symptoms improved and discharged,two cases of postoperative wound fat liquefaction,by dressing wound healing,time stitches discharged.3 to 12 months follow-up visit(average 10 months),all patients could walk uptight without noticeable limp.Last follow-up group,fixed platforms,rotating platform group Knee Score (HSS) and knee activity (ROM) were (83.17 ± 7.12),(81.32 ± 5.39) points and (109.73 ± 6.35) °,(103.12 ± 4.28) °,compared with the preoperative differencewasstatisticallysignificant (AgroupHSS:t =22.10,ROM:t =9.21 ; BgroupHSS:t =30.69,ROM:t =9.54,all P ＜ 0.01),but the difference between groups was not statistically significant(HSS:t =0.88,ROM:t =3.63,all P ＞ 0.05).Conclusion Using PFC and RP prosthesis after total knee replacement system in early has a good effect,both of which improve joint function early with no significant difference,but long-term effects need further observation.