1.Comparison of medical student's mental workload between VDT and paper-based reading.
Xiao-Wu PENG ; Zhen-Cheng XU ; Xiao-Chun PENG
Chinese Journal of Industrial Hygiene and Occupational Diseases 2008;26(12):738-740
Adult
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Computer Terminals
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Humans
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Male
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Paper
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Reading
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Students, Medical
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Workload
2.Effect of phacoemulsification on corneal endothelium of cataract with lupus nephritis
Fen, YE ; Ying-Ying, CHENG ; Yan, WU ; Zhen-Ping, HUANG
International Eye Science 2014;(9):1667-1669
To evaluate the influence of phacoemulsification on corneal endothelium of senile cataract with lupus nephritis (LN).
●METHODS:This clinical trial involved 40 cataract patients with lupus nephritis (40 eyes), and 50 cases (50 eyes) without lupus nephritis. All of them underwent phacoemulsification+lOL implantation. The parameters of corneal endothelial cell including central corneal endothelium cell density ( CED ), average area of endothelial cell ( AVE) and coefficient of variation ( CV) were recorded by corneal endothelial microscope pre -operation and at one month after operation. The data were analyzed by SPSS 13. 0 statistical software.
● RESULTS: Both LN group and control group, the morphology of coneal endothelial was statistical significant differences between pre - operation and 1mo postoperation. The CED was lower, AVE and CV were higher ( P < 0. 05, respectively). A significant decrease in CED was seen in the LN group than did in the control group (P < 0. 05). Compared to control group,the post -operative AVE and CV in LN group was significantly increased (P<0. 05).
● CONCLUSlON: The corneal endothelial cell in lupus nephritis patients is more fragile. Safe and reliable operation should be selected for these patients.
3.Detection of food specific IgG and observation of the therapeutic effect of diet control in children with peptic ulcer
Maoyan ZHANG ; Chuanying LI ; Zhen WANG ; Cheng WU
The Journal of Practical Medicine 2015;(18):3049-3052
Objective To discuss the relationship between peptic ulcer in children and food-specific IgG, and to evaluate the effect of avoiding the intolerant food on treatment of peptic ulcer. Method Fourteen kinds of food specific IgG in 69 cases of peptic ulcer were tested by ELISA. The patient′s intolerance to different foods and its relationship with age , sex and different ulcer were analyzed. The efficacy of avoiding the intolerant food was assessed after 8 weeks. Results Total positive of food-specific IgG in children with peptic ulcer was 94.2%. For preschool children, the highest intolerance rates were in milk and eggs; for school-age and adolescence children, the highest intolerance rate was in eggs. As the age increases, kinds of intolerant food increased too. Ulcer healing rate in observation group was higher than that in the control group after 8 weeks. Conclusions High positive percentage of food- specific IgG was found in children with peptic ulcer , indicating a possible correlation of peptic ulcer and food-intolerance. Kinds of intolerant food correlates with the age group , but not with sex and ulcer sites. Avoiding the intolerant food may increase ulcer healing rate.
5.Penetration needling at special points for 40 cases of stopping lactation.
Hai-yan TIAN ; Li-yuan WEI ; Cheng-zhen WU
Chinese Acupuncture & Moxibustion 2014;34(10):1035-1036
Acupuncture Therapy
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instrumentation
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Adult
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Female
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Humans
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Lactation
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Mastitis
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physiopathology
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therapy
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Young Adult
6.The Detection of Triple Expression of Tuberculosis DNA Vaccines on the Cell Level
Ai-Li MA ; Yi-Cheng CAO ; Zhen-Wu ZHANG ;
China Biotechnology 2006;0(07):-
Objective:A novel tuberculosis DNA vaccine integrating siRNA,fusional antigen and hIL-12 triple expression units was constructed in our laboratory.Methods:To evaluate the independent expression of the three expression units,two eukaryotic expression plasmid pVAX1-siRNA-PVAE[EGFP]-hIL12 with TB fusional gene Ag85B-ESAT6(PVAE) and enhanced green fluorescent protein(EGFP),and pVAX1-siEGFP-PVAE[EGFP]-hIL12 with siRNA coding sequence targeting EGFP instead of Mcl-1L were constructed.Then two plasmids were used to transfer human embryonic kidney 293 cells.Based on EGFP report gene,it was demonstrated that siRNA expression unit and fusional antigen gene were independently expressed.Results:The hIL12 expression at 48h and 72h post transfection were also detected by ELISA analysis up to 1571.63pg/ml and 2392.25pg/ml respectively in the cell culture fluid.Conclusion:The results demonstrated that the novel DNA vaccine with siRNA,TB fusional antigen and hIL12 three expression units in the same plasmid frame is successfully constructed and independently expressed in eukaryotic cells.It laid a foundation for further animal model study on anti-tuberculosis effects of this novel DNA vaccine.
7.The correlation between Val66Met polymorphism in BDNF gene and Alzheimer's disease
Xiao-Ming HE ; Zhen-Xin ZHANG ; Jun-Wu ZHANG ; Yong-Tao ZHOU ; Mou-Ni TANG ; Cheng-Bin WU ; Zhen HONG ;
Chinese Journal of Geriatrics 1995;0(02):-
0.05).Our data also showed no significant association between the genotypes and the severity of the disease.One-way ANOVA showed that BDNF genotype had no association to the age of onset for developing AD.Conclusions Our results indicate that Va166Met SNP in BDNF gene is not associated with AD.
8.Efficacy of donepezil in patients with cognitive dysfunction caused by radiation-induced encephalopathy
Kunyu ZHAO ; Xiaolong HUANG ; Zhen HU ; Rong WU ; Jinping CHENG ; Jingru JIANG ; Yamei TANG
Chinese Journal of Radiological Medicine and Protection 2017;37(6):426-429,441
Objective To evaluate the efficacy and safety of donepezil in the treatment of cognitive dysfunction caused by radiation-induced encephalopathy.Methods A total of fifty-five patients with radiation-induced cognitive impairment were divided into treatment group with extra donepezil 5-10 mg/d combined with conventional therapy and control group with conventional treatment for 16 weeks.The cognitive function was assessed according to Montreal cognitive assessment (MoCA) and mini-mental state examination (MMSE) before and 16 weeks after treatment.Results After 16 weeks of treatment,the patients in treatment group displayed significantly greater improvement in cognitive function.In treatment group,the scores of patients after donepezil therapy in MoCA and MMSE were obviously higher than the control group (t =5.40,3.88,P < 0.01).The scores in the visual space and executive function,naming,attention,abstract thinking,delayed memories also had improved,which suggested the statistically significant difference(t=-3.55,-3.08,-3.21,-2.58,-3.65,P<0.05).The scores of control group unchanged accordingly.Conclusions Donepezil combined with conventional treatment was signally effective in the therapy of cognitive dysfunction caused by radiation-induced encephalopathy.
9.Effects on recovering of corneal wound and postoperative discomfort of different surgical procedures for pterygium
Ting, YU ; Xiang-Fei, CHEN ; Yan, WU ; Yu-Hua, SHI ; Ying-Ying, CHENG ; Zhen-Ping, HUANG
International Eye Science 2016;16(8):1582-1583
?AIM: To evaluate the effects on recovering of corneal wound and postoperative discomfort of different methods for primary pterygium.?METHODS: Forty-seven cases ( 60 eyes ) of primary pterygium were excised under microscope with limbal epithelial transplantation, with sharp dissection ( 24 cases, 30 eyes, Group A) and blunt dissection (23 cases, 30 eyes, Group B).All cases were followed up for 1d to 1mo.?RESULTS: The recovering of corneal wound was better in Group B on 1st day and 3rd day after surgery.Pain, photophobia and tears, foreign body sensation were more serious in group A on 1st day after surgery with a statistically significant difference (P=0.005,0.015,0.012). Pain, photophobia and tears, foreign body sensation were more serious in Group A on 3rd day after surgery with a statistically significant difference ( P=0.019,0.018, 0.015).There was no statistically significant difference on 1wk and 1mo after surgery (P>0.05).? CONCLUSION: Compared with sharp dissection, primary pterygium excised with blunt dissection can significantly improve recovering of corneal wound and postoperative discomfort.
10.Improvement of life quality of children with atopic dermatitis by therapeutic patient education
Zhen ZHANG ; Xiaoyi LIU ; Ying CHENG ; Huan HE ; Jian WU ; Ji CHEN
Journal of Clinical Pediatrics 2016;34(5):338-341
Objective To evaluate the effect of therapeutic patient education on improving life quality of children with atopic dermatitis (AD). Methods A total of 109 children with AD were enrolled, including 53 patients in the intervention group and 56 patients in the control group. The intervention group was given therapeutic patient education in addition to routine treatment, while the control group was given routine treatment without therapeutic patient education. After three months two groups were compared with the disease severity and quality of life in children and their families. Results Compared with control group, the intervention group had significant improvements in severity of AD (P?=?0.003) and also significant improvements in quality of life (IDQOL and CDLQI) (P?=?0.004). The family life quality (DFI) of the two groups were both improved, but the difference was not signiifcant (P?=?0.492). Conclusions Therapeutic patient education can improve symptoms of atopic dermatitis, and the quality of life of children as well.