Drug Stability ; Methylprednisolone Hemisuccinate ; administration & dosage

Antineoplastic Agents ; adverse effects ; therapeutic use ; Diarrhea ; chemically induced ; Drug Delivery Systems ; methods ; Exanthema ; chemically induced ; Humans ; Leukopenia ; chemically induced ; Lung Diseases, Interstitial ; chemically induced ; Myocardial Infarction ; chemically induced ; Neoplasms ; drug therapy ; Tumor Lysis Syndrome ; etiology

As a novel research tool in the field of the spinal biomechanics, the finite element method (FEM) complements and verifies the traditional research methods, which has been attached increasingly greater importance. In this paper, we briefly introduce the achievement made in the field of spinal biomechanics by FEM in the past decade, summarize the physiological and pathological behaviors of various spinal anatomical parts described by FEM, and present the basic view of using FEM to optimize the surgery instrument design.

The role of bracing for adolescent idiopathic scoliosis,which came into application in 1960's,has long been controversial.There are various brace instrument with different reported effectiveness.In this paper,we summarize the research findings and main views in the effectiveness of bracing for adolescent idiopathic scoliosis in the past ten years,and explore the possible causes leading to the different results.Besides,we are trying to point out the research trend,in hope of drawing a scientific conclusion on the effectiveness of bracing treatment in the near future.

Objective To investigate the conventional MRI and perfusion weighted imaging (PWI) features of central neurocytoma(CNC), and to evaluate the potentiality of them in diagnosing accuracy. Methods Three patients with CNC proved pathologically were collected, 4 patients with ependymoma were as control group, with conventional MRI and perfusion weighted imaging were performed in all of them. MRI features were observed, and relative regional cerebral blood volume (rrCBV) were calculated.Results CNCs were isosignal on T_1WI, hyperintense on T_2WI, minimal enhancment. Ependymomas were hypointense or isosignal on T_1WI, slightly hyperintense or hyperintense on T_2WI and minimal enhancement. On PWI, CNCs were obviously high-perfusion, rrCBV was 11.2, but which was 2.1 in ependymoma, there was statistically signifcant difference between two groups(P

Objective To investigate the value of MR perfusion weighted imaging(PWI) features in typing meningioma preoperation.Methods MR perfusion weighted imaging was performed on 39 patients with pathologically proved meningioma.The relative regionalcerebral blood volume(rrCBV) and relative mean transit time(rMTT) were calculated.Results The rrCBV and rMTT of angioblastic meningiomas were 11.8 and 1.8,which were higher than that of the others subtype.The rrCBV of meningothelial meningiomas andtransitional meningiomas were 8.3,7.5 respectively,the rMTT of them were 1.5 and 1.3,there was statistically significant difference in rMTT between two groups,but no difference in rrCBV.The rrCBV of fibrous meningiomas was 4.0,which was lower than that of the others.Conclusion PWI is very useful in typing meninigioma preoperation.

Objective To explore the correlation of peritumoral brain edema( PTBE)size,histologi-cal grades and the expression rate of Ki-67 in gliomas. Methods The data and specimens about 74 cases of gliomas in People's Hospital of Xinjiang Uygur Autonomous Region during 2010-2013 were collected. All cases were confirmed by surgery and pathology. According to preoperative MRI,PTBE was graded. Immunohisto-chemical discriminate the expression of Ki-67. HE coloration distinguish the histological grades. Results In this study,90. 54%(67/74)patients occured PTBE,the incidence of PTBE inⅠ,Ⅱ,Ⅲ,Ⅳlevel of groups were 100%(3/3),78. 95%(15/19),83. 33%(15/18),100%(34/34). Ki-67 expression was positive in 75. 68%(56/74)patients,and the rates were 0,36. 84%(7/19),94. 44%(17/18),94. 12%(32/34) in Ⅰ,Ⅱ,Ⅲ,Ⅳ level of groups. The expression rate of Ki-67 was 57. 14%(4/7),60. 00%(6/10),and 80. 70%(46/57)in normal group,Ⅰ-level groups of PTBE,Ⅱ-level groups of PTBE. The result of Kruskal-Wallis H showed that the PTBE from different grades was statistically significant(H=11. 304,P=0. 010). The expression rate of Ki-67 in different grade gliomas was statistically significant(H=38. 530,P﹤0. 05), The difference of expression Ki-67 in gliomas of different PTBE was statistically significant( H=6. 478,P=0. 039). The result of Spearman rank correlation analysis showed that the PTBE level increased with the histo-logical grade up in gliomas(r=0. 385,P=0. 001). The expression rate of Ki-67 increased with the histologi-cal grade up in gliomas(r=0. 692,P﹤0. 05),and the expression rate of Ki-67 increased with the degree of PTBE up in glomas( r =0. 256,P =0. 028 ). Conclusion Accorrding to the PTBE size,the histological grades and proliferation ability of glioma can be judged pre-operation. Ki-67 can be used as the indicator of pro-liferation activity of tumor,and also be used as the important basis of histological grades.

Objective To investigate the expressions of estrogen receptor (ER) and progesterone receptor (PR) subtypes in human endometrial carcinoma tissues. Methods Thirty samples of normal endometrial tissue and 66 endometrial carcinomas were investigated using western blot assays and reverse-transcription polymerase chain reaction. Results (1)Both ER? and ER? mRNA were significantly increased in endometrial carcinoma compared with that in normal endometrium tissues. The relative value of ER? and ER? mRNA in endometrial carcinoma was 8.00?7.77, 3.84?2.57 and that in normal endometrium tissues was 4.15?3.55, 0.41?0.29, respectively. (2) Decreased levels of PR, PRA, PRB protein and PR mRNA were associated with endometrium carcinogenesis (P

0 05), but MTT had significant difference( F =10 2, P

The survey aims at probing into the current development of medical instruments in hospitals and computerized quality control,upgrading the competence of hospital engineering departments and guiding the development of medical clinical engineering.Questionnaire surveys were made to the medical engineering departments of 195 hospitals above secondary hospitals in Zhejiang,totaling 1001 professionals.The results indicate significant differences among hospitals of various scales in terms of deployment of medical engineering Professionals,working conditions,and computerized applications,yet a consistency in academic title promotion and training requirements.In this consideration,it is imperative to build the team,maintain consistency in professional certification of medical engineering professionals,build a regular and systematic examination,promotion and certification system,enhance training in professional knowledge and equipment quality control,as well as promoting information and resources sharing.All these efforts are essential for better quality control and management of medical engineering departments,and promoting computerized management of medical instruments.