1.Pregabalin as a Neuroprotector after Spinal Cord Injury in Rats: Biochemical Analysis and Effect on Glial Cells.
Kee Yong HA ; Eugene CARRAGEE ; Ivan CHENG ; Soon Eok KWON ; Young Hoon KIM
Journal of Korean Medical Science 2011;26(3):404-411
As one of trials on neuroprotection after spinal cord injury, we used pregabalin. After spinal cord injury (SCI) in rats using contusion model, we observed the effect of pregabalin compared to that of the control and the methylprednisolone treated rats. We observed locomotor improvement of paralyzed hindlimb and body weight changes for clinical evaluation and caspase-3, bcl-2, and p38 MAPK expressions using western blotting. On histopathological analysis, we also evaluated reactive proliferation of glial cells. We were able to observe pregabalin's effectiveness as a neuroprotector after SCI in terms of the clinical indicators and the laboratory findings. The caspase-3 and phosphorylated p38 MAPK expressions of the pregabalin group were lower than those of the control group (statistically significant with caspase-3). Bcl-2 showed no significant difference between the control group and the treated groups. On the histopathological analysis, pregabalin treatment demonstrated less proliferation of the microglia and astrocytes. With this animal study, we were able to demonstrate reproducible results of pregabalin's neuroprotection effect. Diminished production of caspase-3 and phosphorylated p38 MAPK and as well as decreased proliferation of astrocytes were seen with the administration of pregabalin. This influence on spinal cord injury might be a possible approach for achieving neuroprotection following central nervous system trauma including spinal cord injury.
Animals
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Apoptosis/drug effects
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Astrocytes/drug effects/pathology
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Blotting, Western
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Body Weight/drug effects
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Caspase 3/genetics
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Cell Proliferation
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Fluorescent Antibody Technique
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Gene Expression
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Hindlimb/drug effects/pathology/physiopathology
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Inflammation
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Male
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Methylprednisolone/therapeutic use
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Microglia/drug effects/pathology
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Motor Activity/drug effects
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Neuroglia/*drug effects/pathology
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Neuroprotective Agents/*therapeutic use
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Paralysis/drug therapy
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Proto-Oncogene Proteins c-bcl-2/genetics
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Rats
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Rats, Sprague-Dawley
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Spinal Cord Injuries/*drug therapy/pathology
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gamma-Aminobutyric Acid/*analogs & derivatives/therapeutic use
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p38 Mitogen-Activated Protein Kinases/genetics
2.Research progress on musk and artificial propagation technique of forest musk deer.
China Journal of Chinese Materia Medica 2018;43(19):3806-3810
Forest musk deer(Moschus berezovskii) is mainly distribute in Shaanxi and Sichuan provinces of China. The musk is a dry exudates in the mature male sachet with complex chemical composition, abundant modern identification methods, various pharmacological action, extensive clinical application. The population quantity and quality of wild and captive forest musk deer failed to improve because of lacking scientific management, excessive hunting and habitat destruction, etc. Carrying out the captive forest musk deer is an effective way to protect them, fast breeding of forest musk deer is the key to increase the yield of musk. Therefore, we should develop new technologies such as natural estrus and artificial insemination in order to speed up the breeding of musk deer and increase the yield of musk. This article reviews the research progress of new artificial propagation technique and musk, which teases some feasible research basis for optimization of forest musk deer species and the research of musk.
Animals
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Breeding
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methods
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China
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Deer
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Fatty Acids, Monounsaturated
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chemistry
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Female
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Insemination, Artificial
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veterinary
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Male
3.ARCO Consensus on the Pathogenesis of Non-traumatic Osteonecrosis of the Femoral Head
Quanjun CUI ; Woo-Lam JO ; Kyung-Hoi KOO ; Edward Y. CHENG ; Wolf DRESCHER ; Stuart B. GOODMAN ; Yong-Chan HA ; Phillippe HERNIGOU ; Lynne C. JONES ; Shin-Yoon KIM ; Kyu Sang LEE ; Mel S. LEE ; Yun Jong LEE ; Michael A. MONT ; Nobuhiko SUGANO ; John TALIAFERRO ; Takuaki YAMAMOTO ; Dewei ZHAO
Journal of Korean Medical Science 2021;36(10):e65-
Osteonecrosis of the femoral head (ONFH) is a devastating disease frequently leading to femoral head collapse and hip arthritis. Specifically, non-traumatic ONFH primarily affects young and middle-aged adults. Although compromised local circulation of the femoral head seems to be pathognomonic for the disease, the pathogenesis is perplexing and continues to be an area of scrutiny and research. Comprehension of the pathogenesis is of crucial importance for developing and guiding treatments for the disease. Therefore, we provide an up-to-date consensus on the pathogenesis of non-traumatic ONFH.
4.ARCO Consensus on the Pathogenesis of Non-traumatic Osteonecrosis of the Femoral Head
Quanjun CUI ; Woo-Lam JO ; Kyung-Hoi KOO ; Edward Y. CHENG ; Wolf DRESCHER ; Stuart B. GOODMAN ; Yong-Chan HA ; Phillippe HERNIGOU ; Lynne C. JONES ; Shin-Yoon KIM ; Kyu Sang LEE ; Mel S. LEE ; Yun Jong LEE ; Michael A. MONT ; Nobuhiko SUGANO ; John TALIAFERRO ; Takuaki YAMAMOTO ; Dewei ZHAO
Journal of Korean Medical Science 2021;36(10):e65-
Osteonecrosis of the femoral head (ONFH) is a devastating disease frequently leading to femoral head collapse and hip arthritis. Specifically, non-traumatic ONFH primarily affects young and middle-aged adults. Although compromised local circulation of the femoral head seems to be pathognomonic for the disease, the pathogenesis is perplexing and continues to be an area of scrutiny and research. Comprehension of the pathogenesis is of crucial importance for developing and guiding treatments for the disease. Therefore, we provide an up-to-date consensus on the pathogenesis of non-traumatic ONFH.
5.Osteonecrosis of the Femoral Head: an Updated Review of ARCO on Pathogenesis, Staging and Treatment
Jeremy T. HINES ; Woo-Lam JO ; Quanjun CUI ; Michael A. MONT ; Kyung-Hoi KOO ; Edward Y. CHENG ; Stuart B. GOODMAN ; Yong-Chan HA ; Phillippe HERNIGOU ; Lynne C. JONES ; Shin-Yoon KIM ; Takashi SAKAI ; Nobuhiko SUGANO ; Takuaki YAMAMOTO ; Mel S. LEE ; Dewei ZHAO ; Wolf DRESCHER ; Tae-Young KIM ; Young-Kyun LEE ; Byung-Ho YOON ; Seung-Hoon BAEK ; Wataru ANDO ; Hong-Seok KIM ; Jung-Wee PARK
Journal of Korean Medical Science 2021;36(24):e177-
Non-traumatic osteonecrosis of the femoral head (ONFH) usually affects adults younger than 50 years and frequently leads to femoral head collapse and subsequent arthritis of the hip.It is becoming more prevalent along with increasing use of corticosteroids for the adjuvant therapy of leukemia and other myelogenous diseases as well as management of organ transplantation. This review updated knowledge on the pathogenesis, classification criteria, staging system, and treatment of ONFH.
6.Osteonecrosis of the Femoral Head: an Updated Review of ARCO on Pathogenesis, Staging and Treatment
Jeremy T. HINES ; Woo-Lam JO ; Quanjun CUI ; Michael A. MONT ; Kyung-Hoi KOO ; Edward Y. CHENG ; Stuart B. GOODMAN ; Yong-Chan HA ; Phillippe HERNIGOU ; Lynne C. JONES ; Shin-Yoon KIM ; Takashi SAKAI ; Nobuhiko SUGANO ; Takuaki YAMAMOTO ; Mel S. LEE ; Dewei ZHAO ; Wolf DRESCHER ; Tae-Young KIM ; Young-Kyun LEE ; Byung-Ho YOON ; Seung-Hoon BAEK ; Wataru ANDO ; Hong-Seok KIM ; Jung-Wee PARK
Journal of Korean Medical Science 2021;36(24):e177-
Non-traumatic osteonecrosis of the femoral head (ONFH) usually affects adults younger than 50 years and frequently leads to femoral head collapse and subsequent arthritis of the hip.It is becoming more prevalent along with increasing use of corticosteroids for the adjuvant therapy of leukemia and other myelogenous diseases as well as management of organ transplantation. This review updated knowledge on the pathogenesis, classification criteria, staging system, and treatment of ONFH.