In order to provide an experimental evidence for clinical utility, we undertook a series of experimental studies of glucocorticosteroid to treat closed head injury and gun shot brain wound, For studies of closed injury in rats, there were four groups as follows: Group 1: methyl prednisone 30mg/kg (MPG); Group 2: dexamethasone 5 mg/kg (HDMG): Group 3: dexamethasone0.5mg/kg (LDMG); and Group 4: normal saline as a control group (CG) For study of gun shot wound of brain, The dogs were divided into three groups, Grup 1 (wound group, n=8); Group 2 (treated group, n=7) and group 3 (control group, n=7). After injury, the vital signs were observed, the water content of the brain and Even' s blue level were measured and the brain were examined under optical and electronic microscopy, All results proved that secondary traumatic edema in the animals used high dose glucocotricosteroid were much more slight

The left ventricular bands of isolated human heart were studied by microscopy, echocardi ography and gross anatomical method. The results indicate that the structures of the bands were those commonly observed in human heart. They could be classified into two types: myo-bands and tendinous bands. However, we could only differentiate the “bands whose” diameter was more than 1.5mm with Aloka-SSD720 echocardiograph (made in Japan). we suggest that the resolution of the instrument we used was too low, and this might be the main reason that the detection of left ventricular bands was much lower than the incidence, we classified these bands according to the adhering points and diameters of bands.In this paper, the forming factors of bands and their clinical significance are also discussed.

The effect of high dos; dexamethasone(5mg/kg wt, intravenous injection)to prevent and treat the secondary pathological damage of craniocerebral injury was studied in animal models of craniocerebral injury caused by high-velocity missiles in dogs.We observed ths physiological changes, analyzed the value of serum and. cerebrospinal fluid lactate dehydrogenase, estimated the permeability of blood brain barrier (BBB) and studied brain pathology by light and electron microscopy.The results suggest high dose dexamethasone can help to restore ths structure and function of BBB, protect brain cells as well as lessai the secondary pathological damage in tha respiratory and circulatory systems and reduce th production of lipoptrox-ides(LPO).

Animals ; Drugs, Chinese Herbal ; therapeutic use ; Male ; Myocardial Ischemia ; blood ; drug therapy ; Nitric Oxide ; blood ; Nitric Oxide Synthase ; blood ; Phytotherapy ; Rats ; Rats, Sprague-Dawley ; Superoxide Dismutase ; blood

Interventional radiology is a new kind of minimally-invasive therapeutics that has developed on the basis of radiological imaging diagnosis.Interventional radiology is defined as a clinical subject that carries out the specific diagnosis and treatment under the guidance of medical imaging equipment and with the help of puncture needle,guide wire,catheter,etc.The interventional radiology categories include interventional diagnosis and interventional therapy.Interventional medicine is defined from the perspective of clinical application,while interventional radiology is defined from the technical characteristics of diagnosis and treatment.《of Interventional Radiology》 and the upcoming 《Journal of Interventional Medicine (English version)》 will become the professional sister journals in interventional academic field,which will provide important support for promoting the development of interventional medicine in China and for enhancing the international influence power of Chinese interventional medicine.

The changes of immunoreactive TRH (TRH-ir) in cerebrospinal fluid (CSF) and plasma before and after acute traumatic head injury were determined with radioimmunoassay (RIA) on a feline model of acute experimental head trauma. The results showed that the concentrations of TRH-ir in experimental animals pre- and 2, 4, and 6h post-injury were 119.48?51.77, 460.71 ?178.72, 377.27? 139.33, and 280.17?110.46pmol/L in CSF, and 122.58?28.87,1158.89?163.18, 909.69?160.55, and 545.38?132.80pmol/L in plasma, respectively, while those in control animals measured at the corresponding time were 112.22?53.42, 105.36?49.64, 100.63?52.89, and 104.52?52.42pmol/L in CSF, and 113.57 ?25.79, 107.32?26.60, 119.84?31.53, and 117.21?28.95pmol/L in plasma, respectively. The contents of TRH-ir in CSF and plasma in the experimental group after traumatic head injury were significantly higher than those, in the control group (P

The effects of high frequency jet ventilation(HFJV) on brain resuscitation had been investigated in 28 cats in which simple brain functional failure was produced by occlusion of both carotid and both vertebral arteries. The results suggested that HFJV could improve endurance of cats when subjected to brain ischemia, raise the survival rate of cats with reversible brain functional failure, and prolong the survival time of cats with permernent brain functional failure. The mechanisms of how HFJ would exert beneficial effect on brain resuscitation was discussed.

The authors analyzed the current predicament of medical human resources and seek the deficiencies and problems that exist in the medical moral education system .Based on this , this paper pointed out that it should change the medical ethics education ideas , enhance medical ethics cultural identity; based on the health industry demand , broaden the content of the medical ethics education;to develop a new mode of medical ethics education , perfect the evaluation system of medical ethics and health industry demand , provide new guidance for medical eth-ics education .

Objective: To observe the clinical effects on advanced esophageal cancer by combined Xihuang Pill with chemotherapy. Methods: Dividing 35 advanced esophageal cancer cases randomly into two groups: 18 cases in the treatment group and 17 cases in the control group. Cases in the control group were treated by nedaplatin 40mg/m2,d1,2; 5-Fu400mg/m2,d1-5; CF200 mg/m2,d1-5. While the treatment with Xihuang Pill combined. The difference of quality of life, hematological toxicity, efficacy and symptoms between the two groups was observed. Results: The quality of life, remission rate of some symptom in the treatment group were much better than the control group, and the hematological toxicity and efficacy were the same. Conclusion: Xihuang Pill could improve the quality of life of advanced esophageal cancer patient, and alleviate some symptoms.

Objective To explore whetherthere exists Schwann-cell derived neurotrophic factor (SDNF) receptor in peripheral nerve. Methods SDNF binding sites in rat sciatic nerve were studied using 125 Ⅰ-SDNF as a radioligand (radioligand binding assays). Results There exists SDNF specific binding sites in peripheral nerve,and the specific binding sites have the following characteristics:①The equilibrium dissociation constant (kd) was (93.11?0.52) pmol/L.②The maximal binding capacity (B max ) of SDNF was (8.91?0.26)fmol/mg protein.③Saturation.④Kinetic studies revealed that the association rate constant (K 1) was (3.91?0.63)?10 7M -1 ?min -1 and the dissociation constant (K -1 ) was (3.38?0.54)?10 -3 min -1 .⑤Specific studies of SDNF binding sites showed that the binding sites were highly specific for SDNF. Conclusion SDNF receptor exists in the peripheral nerve and the peripheral nerve may be one of target tissues of SDNF.