1.Analysis of epidemiological survey data of mental disorders in Xiamen city and other regions residents
Chinese Journal of Health Management 2015;(4):306-310
Objective By comparing the prevalence of mental disorders and social demographic characteristics, to analyze the influencing factors of mental disorders in Xiamen city residents. Method Using multi-stage stratified cluster random sampling, 12 071 subjects aged 18 years and older were identified in Xiamen city. Eventually 10 764 subjects completed the survey, including 4 957 males, 5 807 females, 8 588 urban population and 2 176 rural population. The subjects were screened with the expanded version of GHQ-12, the Structured Clinical Interview for DSM-Ⅳ-TR as a diagnostic tool, and made a determination whether they had mental disorder and specific diagnosis. Result The overall prevalence of mental disorders in Xiamen city was lower than that in other provinces and cities; it was only 3.46%(Shandong province 19.48%, Zhejiang province 17.27%, Qinghai province 18.04%, Hebei province 16.24%, Tianshui city 17.90%, Chengde city 17.71%, Baoding city 13.62%). The one of most common mental disorders was the alcohol use disorders in various provinces and cities, except in Xiamen city. The constituent ratio of Xiamen residents surveyed was 79.78%for urban, higher than those of other provinces and cities (Shandong province 24.91%,χ2=6 624.955,P<0.001;Zhejiang province 32.95%,χ2=3 601.752, P<0.001;Qinghai province 23.55%,χ2=4 991.289,P<0.001;Hebei province 15.95%,χ2=11 547.016,P<0.001;Tianshui city 16.05%,χ2=6 484.483,P<0.001;Chengde city 15.60%,χ2=2 930.811,P<0.001;Baoding city 11.80%,χ2=6 973.770,P<0.001). Most residents of Xiamen enjoyed at least one kind of health insurance (83.06%), higher than those of other provinces and cities (Zhejiang province 23.30%,χ2=8 868.617,P<0.001;Hebei province 8.68%,χ2=17 434.576,P<0.001;Tianshui city 11.20%,χ2=10 862.305, P<0.001;Chengde city 8.69%,χ2=5 884.478,P<0.001;Baoding city 9.54%,χ2=10 728.632,P<0.001). Conclusion The overall current prevalence of mental disorders in Xiamen city residents was lower than those of other provinces and cities. The reasons may be that there was higher degree of urbanization, better health care, no heavy drinking habits and other factors. There might be other protective factors which need to be further studied.
2.Clinical efficacy of acupuncture and rehabilitation treatment on oculomotor nerve palsy patients
International Eye Science 2014;(6):1165-1167
AIM: To explore the clinical efficacy of traditional Chinese acupuncture combined with conventional rehabilitation therapy onoculomotor nerve palsy patients.METHODS: From May 2005 to September 2012, 110 cases ofoculomotor palsy were divided into treatment group and control group with 55 cases in each group according to different methods of treatment. The control group received rehabilitation therapy, the treatment group received acupuncture combined with rehabilitation therapy. Before and after 8wk treatment, the light reflex, diopter case, eye fissure width, and eye movement to improve the overall efficiency of the situation were observed between the two groups.
RESULTS: After treatment of 8wk, light reflex, diopter case, eye fissure width, and eye movement therapy total effective rate of the treatment group were all better than the control group (P<0. 05);The eye movement improved in the treatment were 47 cases which accounting for 85-5%, in the control group there were 36 cases which accounting for 65. 5%, the treatment group had a higher improvement (P<0. 05).
CONCLUSION: Acupuncture therapy combined with rehabilitation training method significantly reduces the oculomotor nerve palsy in patients with clinical symptoms and improves the patient's quality of life.
3.Construction of C2-7 three-dimensional finite element model of normal adults
Yonggeng CHENG ; Xinwei WANG ; Wen YUAN
Chinese Journal of Tissue Engineering Research 2010;14(17):3058-3061
BACKGROUND: With the fast development of computer technology,biomechanical study of cervical vertebra is not limited in animal or human corpses,because computer model can provide a more accurate model.OBJECTIVE: To develop a three-dimensional,finite element model of a human C2-7 based on previous studies,and to provide experimental data for the biomechanical study of the cervical spine.METHODS: A normal young 28-year-old male,without obvious cervical spondylosis history,was selected,and C-spine X-rays at posteroanterior,oblique,and over extension and over flexion position were performed to deplete cervical spondylosis.The CT scanning images were dealed with Software Mimics and Geomagic to obtain the finite element,and software ANSYS was used to study the response of the model.Under a 1.8 N·m segmenal movement and force displacement response were observed and compared with abroad experimental results.RESULTS AND CONCLUSION: The new finite element model was composed of six vertebrae(C2-7),five discs(C2/3-6/7)and main ligaments.The model consisted of solid elements with 23 348 nodes and 215 749 units.The results of the biomechanical study were better correlated with the available experimental data.It indicates that the finite element model of cervical spine at C2-7 can be used to imitate the biomechanical experiment of cervical spine.
4.Changes of thyroid function in depressive patients with attempted suicide
Minfeng CHENG ; Shenglin WEN ; Houliang WANG
Chinese Journal of General Practitioners 2010;9(5):343-344
Thyroid function [triiodothyronine(T3), thyroxine(T4), free T3(FT3), free T4(FT4),and thyroid stimulating hormone (TSH) ] were tested by radioimmunoassay in 56 depressive patients with attempted suicide, 85 patients without suicide attempt and 40 healthy subjects (controls).The serum levels of T3 and FT3 in the patients with attempted suicide were lower than those in the patients without suicide attempt and the controls ( F = 4.937 and 5.01 1, both P < 0.05 ).The lower serum levels of T3 and FT3might be the risk factor of suicide in depressive patients.
5.Clinical symptoms and thyroid function between depressive patients with and without attempted suicide behavior
Shenglin WEN ; Minfeng CHENG ; Houliang WANG
Journal of Chinese Physician 2010;12(8):1060-1062
Objective To explore the characteristics of both clinical symptoms and thyroid function between depressive patients with and without attempted suicide behavior. Methods Depressive patients were divided into two groups. The first group was composed of patients with attempted suicide behavior (n = 56) and the second group without attempted suicide behavior ( n = 85 ). Thyroid function (FT3, FT4 )were determined by radioimmunoassay method. The patients were evaluated by symptom checklist 90 (SCL90). Results The score of depressive factor in the group with attempted suicide [(2. 90 ± 1. 01 ) score]was higher than that of the group without attempted suicide [(2.51±0.77) score] ( ( t =2. 127, P =0. 036). The serum level of FT3 in the group with attempted suicide [(3.92 ±0. 52) pmol/L] was lower than that of the group without attempted suicide[(4.18 ±0.71) pmol/L] ( t =-2.219, P =0.028).Conclusions There were certain characteristics on clinical symptoms of depressive patients with attempted suicide. The low serum levels of FT3 might play an important role in the risk of suicide in depressive patients.
6.Exploration of the relationship between ultrasonographic features of papillary thyroid carcinoma and lat-eral cervical lymph node metastasis
Qiucheng WANG ; Wen CHENG ; Xin WEN ; Jiebing LI ; Chunlei NIE
Practical Oncology Journal 2014;(1):49-53
Objective To investigate the relationship between ultrasonographic features of papillary thy-roid carcinoma(PTC)and lateral cervical lymph node metastasis (LCLNM).Methods A total of 449 eligible ca-ses with 633 PTC nodules was selected and divided into two groups:LCLNM group included 135 nodules(91 pa-tients);Without metastatic groups included 498 nodules(135 patients).Ultrasonographic features of PTC nodules and the relationship with LCLNM were analyzed by χ2 test and logistic regression analysis .Results In univariate analysis,the significant factors were male,age<45yrs,multifocal,maximal diameter(d>1 cm),multi-microcal-cificaltion(d<2 mm),mixed flow,wider than tall,CCLNM,extrathyroid extension,located in upper(P<0.05 or P<0.017).Multivariate analysis showed that multi -microcalcificaltion(d<2 mm),wider than tall,CCLNM,ex-trathyroid extension,located in upper pole were predictive factors of LCLNM (P<0.005,OR=1.626,2.644, 0.479,2.579).Conclusion High-frequency ultrasound can accurately describe the sonographic appearance of thyroid nodules;it can be used to remind the risk of LCLNM before operation ,and will be informative for the treat-ment of surgery .
7.Effects of Aminoguanidine on Blood Brain Barrier and Brain Ischemic Damage during Reperfusion of Cerebral Ischemia in Rats
wen-an, WANG ; geng-fa, WANG ; yong-wei, ZHOU ; jie, CHENG
Journal of Shanghai Jiaotong University(Medical Science) 2006;0(07):-
Objective To evaluate the therapeutic effects of aminoguanidine(AG) on cerebral ischemia-reperfusion damage in rats. Methods The intravascular thread models with 2 h of occlusion and 22 h of reperfusion were made in the rats.The brain infarction size and the degree of blood brain barrier(BBB) disruption in the ischemic regions were evaluated by staining with 2,3,5-triphenyl tetrazolium chloride and observing with Evans blue fluorescence microscope.HE staining was utilized for observing neutrophil infiltration. Results The brain infarction(volume,) the area of BBB disruption and the degree of neutrophil infiltration were dramatically decreased in the treatment group as compared to the control group(P
8.Diagnostic value of 64-slice CTA to head and neck artery lesions of the elder
Fengling ZHANG ; Gang CHENG ; Wen HE ; Pengfei WANG
Journal of Chinese Physician 2016;18(2):220-223
Objective To investigate the diagnostic value of 64-slice CT angiography (CTA) to head and neck artery pathological changes.Methods One hundred patients with clinical suspicion of head and neck vascular lesions were retrospectively analyzed.Sixty four cases of lesions were detected by 64-slice CTA,and were checked by Digital Subtraction Angiography (DSA) within a week.First,the correlation of 64-slice CTA and DSA diagnosis of head and neck artery stenosis grade was counted.Then DSA was taken as the gold standard.The sensitivity,specificity,positive predictive value,and negative predictive value of 64-slice CTA to diagnose head and neck arteries stenosis were calculated.Results Of 64 cases of patients,2 cases of congenital vascular dysplasia,including 1 case with internal carotid artery in 2 cases,the remaining 60 patients had different degree of stenosis.The sensitivity,specificity,positive predictive value,and negative predictive value of 64-slice CTA was 95.34%,99.48%,97.62%,and 98.98%,respectively.Among 60 narrow patients,the plaque number was 205,including 88 soft plaques,56 mixed plaques,and 61 calcified plaque.Conclusions The 64-silce CTA has multiple advantages including rapid,noninvasiveness,high accuracy and safety,and high application value in the diagnosis of head and neck vascular lesions.It is worth promoting.
9.Preliminary experience with real-time shear wave elastography monitoring of thermal ablation of liver cancer
Jing DONG ; Wen CHENG ; Qiucheng WANG ; Lei ZHANG ; Yixin SUN
China Oncology 2016;26(2):145-150
Background and purpose:Thermal ablation (radiofrequency ablation, RFA/microwave ablation, MWA) is the most commonly used minimally invasive technique for the treatment of liver cancer. Real-time shear wave elastography (SWE) is a new type of ultrasonic imaging technology, which was used in our study to monitor thermal ablation of liver cancer. This study aimed to investigate the stiffness change of liver cancer and that of surrounding liver parenchyma before and after thermal ablation, and to evaluate the application of SWE for monitoring thermal ablation for liver cancer.Methods:From Oct. 2014 to Apr. 2015, a total number of 36 patients, with 39 lesions, were treated with RFA or MWA and got complete response. SWE examination was performed before and after ablation. The SWE-mean, SWE-min, SWE-max, SWE-SD of lesions and the surrounding liver parenchyma were measured. Statistical analysis was made to compare the stiffness changes of liver cancer with those of the surrounding liver parenchyma before and after thermal ablation, and to determine whether there were differences between two different ablation modes.Results:Before and after ablation, the SWE-mean of lesions was (30.09±11.67) kPavs (52.11±17.56) kPa,SWE-min was (10.46±8.22) kPavs (20.57±11.42) kPa, SWE-max was (51.50±20.84) kPavs (88.54±27.75) kPa, SWE-SD was (10.63±4.30) kPavs (16.89±7.72) kPa; There were statistically signiifcant differences (P<0.05). Before and after ablation, the SWE-mean of surrounding liver parenchyma was (8.84±2.82) kPavs (8.91±2.78) kPa, SWE-min was (4.77±1.95) kPavs (4.69±1.90) kPa, SWE-max was (13.82±3.79) kPavs (14.34±3.97) kPa, SWE-SD was (3.24±1.32) kPavs (3.37±1.29) kPa; There were no statistically signiifcant differences (P>0.05). After ablation, the SWE-mean of RFA and MWA was (45.55±10.91) kPavs (60.59±20.99) kPa, SWE-min was (18.95±8.86) kPavs (25.93±10.93) kPa, SWE-max was (76.58±15.51) kPavs (104.01±32.59) kPa, SWE-SD was (13.82±3.52) kPavs (20.85±9.77) kPa; There were statistically signiifcant differences (P<0.05).Conclusion:SWE can quantitively analyze the stiffness of lesions. The ablation zone became stiffer after RFA or MWA, and the ablation zone of MWA was stiffer than that of RFA. Two kinds of ablation methods did not signiifcantly affect the stiffness of liver parenchyma around the lesion. SWE could potentially be used to monitor thermal ablation of liver cancer.