The ischemic myocardium in cultured myocardial cell of newborn rat and treated with Sodium Selenite(Se) and Fructose-1, 6-diphosphate(FDP) were studied comparatively by means of morphometry and quantitative cytochemistry. The area of myocardial cell and mitochondrion and the content of succinic dehydrogenase (SDH) in myocardial cell were quantitated by texture analysis system (TAS). Lipid peroxidation(LPO) and the myocardial cell beat function were observed. The results showed that the changes of the mitochondrion area interrelated with its number remarkabiy. When the mitochondrion area enlarges more than two fold, the destruction of mitochondrion is remarkable. Both Se and FDP can protect the ischemic myocardial cell, but the effects Se on forestalling destruction of mitochondrion, maintaining vitality of SDH and reducing content of malondialodehyde (MDA) are more powerful than FDP, and the effects of FDP on reducing edema of myocardial cell and mitochondrion, improving myocardial cell beat function are better than Se.

Palmer-foot hyperhidrosis is one kind of focal hyperhidrosis, with symptoms of sweating hands or feet. Some people even have sweat dripping off their hands or feet. This article studied the views of TCM on palmer-foot hyperhidrosis, expounded the pathological and physiological relationship between palmer-foot hyperhidrosis and spleen and stomach, and proposed that clinical treatment should be based on the syndrome differentiation and treatment of spleen and stomach, which can achieve certain efficacy.

Accidents, Occupational ; mortality ; Animals ; Cause of Death ; Humans ; Male ; Nitriles ; poisoning ; Rats

China ; epidemiology ; Humans ; Neoplasms ; epidemiology

Objective To determine the clinical valuation of different ways of hysteroscopic surgery for endometrial polyps. Methods Clinical effects were analysed retrospectively on total 86 patients underwent different ways of hysteroscopic surgery according to women physiological stages, the desire of fertility and clinical symptoms, the mean followed-up duration was (18±6) months. Results Among 86 cases, after polyps resected. In 53 cases menstrual change, 48 cases were cured, 5 cases were invalid. In 20 cases dysmenorrhea, 16 cases were valid, 4 cases were invalid. In 22 cases secondary anemia, 18 cases were cured, 4 cases recovered. Conclusions Fertile stage: uterine curettage should be undergone for patients without menstrual change after polyps resected; among patients with menstrual change, whole layer of endometria were resected for the ones (more than 40 ages) without desire of fertility and superficial layer of endometria were resected for the others after polyps resected. Perimenopause: uterine curettage should be undergone for patients without menstrual change and whole layer of endometria were reacted for patients with menstrual change after polyps resected. Postmenopause: uterine curettage should be undergone for patients without vaginal bleeding and endometria ablation should be carried out for patients with vaginal bleeding.

The cytotoxic effect and antitumor effect of paclitaxel liposome were studied by using MTT assay method in vitro and in vivo antitumor test. The inhibitory rate of paclitaxel liposome on human ovarian cancer cell COC1 was 78.48 %, 84.90 %, 93.53 % respectively at the concentrations of 22.5 μg/ml, 45 μg/ml, 90 μg/ml respectively. Under the doses of 5 mg/(kg*d) and 10 mg/(kg*d) for 8 days, the inhibitory rate of paclitaxel liposome against xenograft of solid Ehrlich tumor in mice was 32.47 % and 54.63 % respectively (P<0.01). The weight change rate of the mice was 22.11 % and 21.16 % respectively. It was suggested that paclitaxel liposome possessed in vitro and in vivo antitumor activities. The toxicity of liposomal paclitaxel was lower than that of free paclitaxel.

Chemical and Drug Induced Liver Injury ; Humans

Chondroblastoma of the patella, rare occurred in patellar,is a kind of an uncommon benign bone tumor. Compared with giant cell tumor, the morbidity of chondroblastoma is lower. Meanwhile, its clinical manifestations are various, and images are very complicated. Therefore, the understanding of this kind of tumors may be limited even to the orthopedist. The differences of patellar chondroblastoma between other tumor in X-ray, CT and MRI is a spot in recent years. Sometimes patellar chondroblastoma coexists with aneurysmal bone cyst, which is a challenge to obtain an accurate pathological and radiological diagnosis. For the treatment, curettage and bone grafting is one the most popular method, but whether to perform a biopsy before surgery still remain controversy. Some new technique still has an unknown prospect for the treatment such as radiofrequency ablation.
Bone Neoplasms ; diagnosis ; surgery ; Chondroblastoma ; diagnosis ; surgery ; Humans ; Patella ; surgery

As the rapid development of genomics , functional genomics and information technology , precision medicine came into being after evidence-based medicine .Precision medicine not only urges clinical doctors to analyze disease at a molecular level to a -chieve precision diagnosis , but also requires us to seek the best therapeutic targets according to the patient 's genetic information to a-chieve precision treatment .The United States and China have launched their precision medicine initiative in 2015 , thus the precision medicine era is coming .This review will focus on gene sequencing , big data integration , molecular pathology , non-invasive prenatal precision diagnosis , and precision cancer medicine to elucidate the application of precision medicine concept in clinical practice .

Inflammasomes are multiprotein complexes that can recognize pathogenic microorganisms and stress -asso-ciated endogenous molecules and play an important role in innate immune system .Inflammasomes cause inflamma-tion response by inducing maturation of inflammatory cytokines interleukin ( IL)-1βand IL-18 through activation of caspase-1 ,and involve in the pathogenesis of various diseases such as cryopyrin-associated periodic syndrome , is-chemia-reperfusion injury and atherosclerosis .