During the treatment of pediatric tumor,vincristine is one of the most widely used and most effective drugs. However,the adverse reactions have limited its clinical application. In recent years,studies have found that the metabolism of vincristine are different in different races and different individuals,and co-ad-ministration with certain drugs such as imidazoles antifungal drugs may enhance its adverse reaction. Resear-ches on new drug delivery system provide a new idea for reducing the adverse reactions of vincristine and impro-ving its bioavailability.

Acupuncture Points ; Acupuncture Therapy ; instrumentation ; methods ; Adult ; Blepharoptosis ; therapy ; Female ; Humans ; Male ; Needles

〔Abstract〕 Taking some college and university libraries in China and the United States as investigation objects, based on internet and literature investigation methods, the paper compares the situation of embedded subject service in the US and China from the aspects of embedded in learning environment of students, embedded in teaching environment of teachers, embedded in scientific research environ-ment of users, etc.Then it points out the shortage and gives some suggestions for embedded subject service in Chinese college and univer-sity libraries.

[Summary] Laparoscopic sleeve gastrectomy ( LSG) as a sole and definitive bariatric surgery has achieved well results in terms of decreasing the body mass index ( BMI ) and percentage of excess weight loss (%EWL ) , therefore reducing the obesity-related complications , but the mechanism remains unclear .As a restrictive surgical procedure , the most important mechanism of LSG might be the reduction of the volume of the stomach resulting in a limited food intake .Therefore, to achieve the best weight loss after surgery , measuring the gastric volume is an indispensable technology .Currently, gastric capacity measurement methods include imaging measurements and intraoperative direct measurement . Imaging methods include upper gastrointestinal radiography , CT three-dimensional reconstruction , MRI and radionuclide scanning , with each having its advantages and disadvantages .In this article, the measurement methods of gastric capacity before and after LSG were reviewed .

OBJECTIVE:To provide the ideas about how the chain drugstores to reply to drug price war.METHODS:Economically,the competition between drugstore was discussed and the respective advantages and disadvantages of fair-price and chain drugstores were analysed.RESULTS &CONCLUSION:Chain drugstores should improve their pharmaceutical service,base oneself upon market voids,and exert self-advantages,if they want to win in price war.

Hepatic hemangioma is the most common benign liver tumors in the clinic.Most of hemangioma does not require aggressive treatment,and the indications for resection remain controversial.Different scholars may have different ideas about the surgical treatment of hemangioma.This article will focus on reviewing literatures about indications of hepatic hemangioma.In this paper,we proposed a new standard of surgical indications that named health-related quality of life.

Neuroblastoma(NB)is the most common extra -cranial malignant tumor of children.While it ac-counts for 7% of all childhood malignancies,NB accounts for 1 0% of childhood cancer mortality.According to the risk group classification systems,there is high heterogeneity malignant degree of NB.Many bio -features are associated with the prognosis of NB.As the development of the diagnosis and therapy,the relationship between some bio -features and the prognosis has been changed.In the future,target therapy of molecular biology may be a new breakthrough in the therapy area.

Objective: To study the effect of nerve growth factor (NGF) on bone fracture healing of inflicted T10 spinal cord injury (SCI) complicated with tibia fracture in rats. Methods: Totally 120 rats were randomly divided into tibia fracture group (F group, n=40), T10 SCI + tibia fracture group (FS group, n=40), and T10 SCI + tibia fracture + NGF group (FSN group, n=40). Four weeks later, the fracture sites in the 3 groups were subjected to CT scanning; the maximum transverse diameter of the fracture ends and the gray scales of non-osseous area were measured; the changes of biomechanics property of the fracture ends were determined by three-point bending test; the bone morphometry, bone density, and histomorphology of callus were determined; the expression of OCN was detected by immunohistochemical method; the osteoblast ultrastructure was observed by TEM and the expression of I, II type collagen were examined by Western blotting. Results: The maximum transverse diameter of F group was less than those of FS group(P<0.01)and FSN group (P<0.05), and FS group was longer than FSN group(P<0.05); the comparison of gray scales among 3 groups had a similar result to that of the section diameter. Three points bending test and bone morphometry test showed that the biomechanics property of the fracture ends in F group were better than those of the other 2 groups (P<0.05), and FSN group was better than FS group (P<0.05). The expression of OCN and type I collagen in the callus of F group was significantly higher than that of the other 2 groups (P<0.05), and FSN group was higher than FS group (P<0.05); while the expression of type II collagen in F group was lower than that of the other 2 groups(P<0.05), and FSN group was higher than FS gourp (P<0.05). Morphological and ultrastructure observation showed that fracture in F group had the best healing result, and the healing result of FSN group was better than that of the FS group. Conclusion: It is suggested that denervation can affect the ossification of fracture ends and NGF can promote the ossification of fracture ends suffering denervation.

Objective To study the chest X-ray appearances and dynamic imaging changes in severe acute respiratory syndrome diagnosed clinically. Methods The sequential chest X-ray examinations at 1-4 day intervals were performed in 72 patients with severe acute respiratory syndrome. Results The findings on chest X-ray images were analyzed. The abnormalities on the chest X-ray films most commonly occurred at 4-7 days after onset (53 cases, 73.6%), and the most severe manifestations on the chest films usually presented at 8-14 days (54 cases, 75.0%). The absorption of the abnormal changes on the films occurred at 15-21 days in most cases (37 cases, 51.4%). The main features included bilateral or unilateral single or multiple patchy shadows (58 cases, 80.6%), and the lesions changed rapidly at the peak period. The lesions presented wandering features in some cases. The lesions still remained on CT scans in 11 cases (11/20, 55.0%) within one month after the absorption on X-ray film. Conclusion The chest radiography can be used to display dynamic changes of SARS, but it isn't able to distinctly demonstrate tine pulmonary lesions of SARS.

Catecholaminergic polymorphic ventricular tachycardia is a rare hereditary ion channel disease, which mainly affects children and young adults.Clinically, the pathogenic genes of CPVT in adolescents are mainly RYR2, CASQ2, TRDN, CALM1 and TRD.Currently, beta blockers remain the first-line treatment for CPVT, and moderate exercise training is considered as an effective potential synergism for CPVT patients.Implantable cardioverter defibrillators are commonly used in the treatment of CPVT, but inappropriate shocks and device-related complications need to be carefully considered before implantation.Flecainide has been shown to be effective therapeutic agent, especially for the treatment of resistant CPVT cases with beta blockers.Left cardiac sympathetic denervation has also shown to be highly effective in preventing CPVT symtoms and cardiac events, and a combination of beta blockers can precede implantable cardioverter defibrillator implantation.