Objective To evaluate the elderly coronary in-stent restenosis risk factors and the incidence of restenosis. Methods Coronary angiography in 143 cases of patients with coronary heart disease were randomly selected, analyzing the characteristics of coronary heart disease, and 89 patients of them were reviewed coronary angiography, restenosis was observed, and the restenosis factors including age, sex, hypertension, diabetes, hyperlipidemia and coronary lesions, stent properties were analyzed. Results Statistical multi-vessel disease in patients with coronary heart disease was 73.9% ,restenosis rate was 23.5%. One narrow and contrast the age of the patients without stenosis and no statistically significant difference between lipids. The number of diabetes cases in the two comparison groups,stent length and stent volume were significant different. One bare stent restenosis rate was significantly higher than the drug-eluting stent group. Conclusion The results showed that diabetes ,stent length,multiple stents, stent restenosis,were the relevant factors of coronary restenosis.

Objective To explore the effect of dexmedetomidine(DEX)for blood pressure,heart rate(HR) and SpO2 levels during anesthesia inquiry in elderly hypertensive(HBP)patients.Methods 96 cases with HBP accepted surgery were selected,and were randomly divided into the observation group and the control group,each group in 48 cases,The patients in the observation group continuous pumped into the 4μg/mL of DEX during surgery, while the control group continuous pumped into 0.9% sodium chloride solution during surgery.Heart rate(HR),sys-tolic blood pressure(SBP),diastolic blood pressure(DBP),pulse oxygen saturation(SpO2 )of the two groups after room entrance(T0),after DEX infusion(T1),before intubation(T2),after 2min intubation(T3)and 10 min(T4)after intubation were recorded and compared,extubated time,spontaneous breathing recovery time,call time to eye opening and hospitalization time and the incidence of adverse reactions in two groups were recorded.Results The difference of HR SBP,DBP and SpO2 at T0 and T4 between the two groups was not statistically significant(all P >0.05);HR, SBP and DBP were significantly lower in the observation group than those in the control group at T1,T2,T3(all P <0.05).There were no significant changes of SpO2 in the patientˊs after the room entrance;extubated time,spontaneous breathing recovery time,call time to eye opening and hospitalization time in the observation group were significantly lower than those in the control group(t =8.874,9.073,8.573,all P <0.05).The adverse reactions rate in the observation group was 4.2%,which in the control group was 6.3%,the difference was not statistically significant(P >0.05). Conclusion Continuous pumped DEX has a significant sedative effect in elderly HBP patients during surgery,and does not produce respiratory depression,can help elderly patients with HBP smoothly pass the perioperative period.

AlM:To analyze and explore the clinical efficacy of strengthening lateral tarsal strip and advancing lower eyelid retractor for the treatment of degenerative entropion with eyelid relaxation
METHODS: Reviewed from January 2011 to January 2013, 21 cases (33 eyes) of degenerative entropion eyelid relaxation were treated with operation of strengthening lateral tarsal strip and advancing lower eyelid retractor ( fornix conjunctival incision ) , the follow-up was 12-24mo, curative effect was observed.
RESULTS: All the patients were cured completely, have no recurrence or overcorrection phenomenon. The cure rate of operation was 100%, there was no complication.
CONCLUSlON: Operation of strengthening lateral tarsal strip and advancing lower eyelid retractor is a safe, reliable, efficient operation to the treatment of degenerative entropion with mode of eyelid relaxation.

Leptin is type I cytokine detected recently.It takes part in physiological action such as energy balance, fat storage and process of metabolism,reproduction and hemopoiesis in vivo.Leptin may be an important role between adipose tissue and genital system.Lack or excessive of leptin is related to infertility in some diseases involving in nutritional status. Leptin takes part in female infertility pathogenesis in hypothalamus pituitary gland gonad axia and other respects.

Objective To evaluate the association between genetic polymorphisms in promoter regions of matrix metalloprotein‐ase‐1 (MMP‐1)‐1607bp1G/2G ,matrix metalloproteinase‐7 (MM P‐7)‐181‐bpA /G and susceptibility of cervical cancer using Meta‐analysis .Methods Relevant studies that had relationships of the polymorphism in promoter regions of matrix metalloproteinase‐1 (MM P‐1)‐1607bp1G/2G ,matrix metalloproteinase‐7 (MMP‐7)‐181‐bpA /G and susceptibility of cervical cancer were collected as case‐control groups .RevMan5 .0 software was applied to analyze the odds ratios (OR) and 95% confidence intervals(CI) of the as‐sociation between polymorphisms and susceptibility of cervical cancer .Results Finally ,6 studies were selected ,containing 4 studies of MMP‐1 and 2 studies of MMP‐7 .For MMP‐1‐1607bp1G/2G ,OR was 0 .76 (95% CI = 0 .51 - 1 .13 ,P= 0 .17) under 1G/1G +1G/2G ∶ 2G/2G model ,OR was 0 .72 (95% CI = 0 .42 - 1 .23 ,P = 0 .42) under 1G/1G ∶ 2G/2G model ,OR was 0 .79(95% CI =0 .57 - 1 .09 ,P= 0 .15) under 1G ∶ 2G model ,it was concluded that there was no statistical significance between them .For MM P‐7‐181bpA /G ,OR was 0 .47 (95% CI = 0 .30 - 0 .74 ,P= 0 .001) under AA + AG ∶ GG model ,OR was 0 .43 (95% CI = 0 .26 - 0 .74 , P= 0 .002) under AA ∶ GG model ,OR was 0 .77(95% CI = 0 .62 - 0 .94 ,P= 0 .02) under A ∶ G model ,there were statistical signifi‐cance differences under all models .Conclusion Polymorphisms in promoter of MMP‐7‐118bpA/G are associated with the suscepti‐bility of cervical cancer and an allele is a protective factor .It is still not confirmed that significant association between the MM P‐1‐1607bp1G/2G and susceptibility to cervical cancer exists in current literature .

The paper discusses the necessity and urgency of hospital ownership reform. and pinpoints the focal and difficult points of the task. It also identifies the goals of the reform, viz. establishment of a medical and health system that fits in with the development demands of a socialist market economy, which is of great significance. It can be seen both in theory and in practice that for a pretty long period of time in China, public hospitals, providing basic medical security for the broad masses of people will occupy a leading position whereas private hospitals known for their outstanding service and quality, will play a bigger role only when the living standards of the general population have reached a fairly high level.

OBJECTIVE:To stndy the clinical efficacy and safety of somatostatin combined with pantoprazole sodium in the treatment of severe acute pancreatitis(SAP). METHODS:By retrospective analysis,98 patients with SAP were divided into control group and observation group by the different treatment. All patients were treated by routine treatment of SAP. Based on it,patients in control group were given Pantoprazole sodium for injection 40 mg adding into 0.9% sodium chloride injection 100 ml,iv,twice a day;patients in observation group were given Somatostatin for injection 3 mg adding into 0.9% sodium chloride injection 100 ml based on the treatment of control group,by micro intravenous continuous intravenous infusion,0.25 mg/h,twice a day.Both cours-es were 7 d. The clinical data was observed,including clinical efficacy,improvement time of signs and symptoms(remission time of stomachache,recovery time of gastrointestinal function,withdrawal time of ventilator) and tumor necrosis factor-α(TNF-α), high-sensitivity C-reactive protein (hs-CRP),interleukin-8 (IL-8) levels and the incidence of adverse reactions before and after treatment. RESULTS:The total effective rate in observation group was significantly higher than control group,and the improve-ment time of signs and symptoms was significantly shorter than control group,with significant differences(P<0.05). After treat-ment,the inflammatory cytokine levels in 2 groups were significantly lower than before,and observation group was lower than con-trol group,with significant differences(P<0.05). The incidence of adverse reactions in observation group was significantly lower than control group,with significant difference(P<0.05). CONCLUSIONS:Based on the routine treatment,somatostatin combined with pantoprazole sodium has better efficacy than only pantoprazole sodium,with better safety.

Objective To study the active secondary metabolites from marine microorganism FIM02-635.Methods The producing strain was identified by taxonomical and phylogenetic studies.Two compounds FW635I1 and FW635I2 with immunosuppressive activities were extracted by organic solvents from the culture broth and purified by silica gel column chromatography and high speed counter current chromatography.The structures of the two compounds were determined by physico-chemical properties and spectral analyses,the biological activities were assayed in vitro.Results and Conclusion The producing strain was named as Micromonospora carbonacea FIM 02-635. Two compounds FW635I1 and FW635I2 were determined to be isoflavone Daidzein and Genistein,respectively,showed immunosuppressive and antitumor activities,but not antimicrobial activities.

Neovascularization plays an essential role in the process of renovation in tissue damage,tumor growth, and hormones action. Parathyroid hormone (PTH) is one of the basic hormones that regulate the serum calcium, phosphorus, and bone metabolism. In recent years, studies involving the neovascularization-mediated effects of PTH on metabolism are becoming more and more popular and wider. Based on recent researches, the purpose of this paper is to summarize the changes of angiogenesis while PTH interacts with its target organs, especially interacts with osseous tissue.

Objective To evaluate the clinical application value of flow fluorescence assay in determination of serum pepsinogenⅠ and Ⅱ.Methods The precision of flow fluorescence assay in the detection of serum pepsinogen Ⅰ and Ⅱ were evaluated. Methodology comparison were conducted between flow fluorescence assay and enzyme-linked immunosorbent assay(ELISA)kit through detecting clinical samples.The reference ranges for PGⅠ and PGⅡ/PGⅠ ratio of healthy population were established. The levels of PGⅠand PGⅡ/PGⅠ ratio were detected in serum samples of patients suffering superficial gastritis,atrophic gastritis and gastric cancer.Results The within-run and between-run coefficient of variation of PGⅠ were 4.26%-5.35% and 6.73%-7.75%,respectively.And those of PGⅡ were 5.48% - 6.42% and 8.46% -8.85%,respectively.Methodology comparison be-tween flow fluorescence assay and ELISA demonstrated good linear correlations.The linear equation wasY =0.91 1X -22.635(r=0.966,P <0.05)and Y =0.892X -0.548(r=0.980,P <0.05)for PGⅠ and PGⅡ,respectively.The lower limit of the reference range of PGⅠ and PGⅡ/PGⅠ ratio were 32.77 ng/mL and 4.1 6,respectively.The PGⅠ and PGⅠ /PGⅡ ratio of patients suf-fering atrophic gastritis and gastric cancer were statistically significantly lower than those in patients suffering superficial gastritis (P <0.05).Conclusion The flow fluorescence assay could conduct simultaneous detection of PGⅠ and PGⅡwith good methodo-logical performance and high efficiency.The determination of PGⅠ and PGⅡlevels through flow fluorescence assay could provide laboratory basis for the screening and diagnosis of atrophic gastritis and early gastric cancer.