Chemical and Drug Induced Liver Injury ; Humans

Humans ; Myocardial Infarction ; diagnosis ; Takotsubo Cardiomyopathy ; diagnosis

Arthroscopy ; methods ; Humans ; Knee Injuries ; surgery ; Shoulder Joint ; injuries

Objective To explore the influencing factors of pharmacotherapy effect of ectopic pregnancy and nursing measures. Methods 569 patients with ectopic pregnancy using pharmacotherapy were retrospectively analyzed in our department. Results Among 569 patients,423 patients gained successful treatment,while 146 patients failed the treatment.Blood β-HCG level,diameter of ectopic mass showed by B ultrasound were influencing factors of pharmacotherapy effect.The higher β-HCG level,the longer diameter of ectopic mass showed by B ultrasound,the lower success rate of pharmacotherapy.The patients with β-HCG＜1000 mIu/ml,diameter of ectopic mass showed by B ultrasound less than 1 cm at admission acquired higher success rate of pharmacotherapy. Conclusions Patients with ectopic pregnancy who select conservative medication should be given pertinent psychological nursing,rigorous monitoring of disease condition and adverse reaction of drugs and timely and effective nursing measures,so that patients can get better nursing effect.

Objective To explore the correlation of infants with asthma and food allergens,to povide the basis for early prevent the development of asthma.Methods The U-niCAP-100 automatic detection system was used to check the common food allergens in serum of 79 infants with asthma and 68 healthy children of the same age.Results The positive rate of serum total IgE in the group of asthma was 64.6％,significantly higher than the healthy group (45.6％)(P＜0.01).The positive rate of serum SIgE was showed that:the mainly food allergens of the asthma group was milk(63.2％)and whole egg(26.3％)which were,significantly higher than the healthy group(36.8％,14.7％)(P ＜ 0.01 and P ＜ 0.05).Conclusion Asthma of infant had close relation with the food allergens.Early avoid food allergens had an important role in preventing the development in low-age children with asthma.

Objective To investigate the changes of peripheral benzodiazepine receptors (PBRs)in rat spinal cord synaptosomes during ageing and to explore the correlation between PBRs in spinal cord synaptosomes and PBRs on platelet membranes.Methods A total of 24 Sprague-Dawley rats were divided into 3-month group and 24-month group (n=6 males and 6 females for each).All animals were sacrificed by decapitation and the spinal cords were immediately removed.Synaptosomal fractions from spinal cords were isolated by gradient centrifugation.The platelet membranes were prepared from venous blood by the method of hypotonic haemolysis.The specific binding of the radioactive PBRs antagonist [3H]PK11195 to membranes was determined.Results No significant differences in [3H] PK11195 binding activity in spinal cords and platelet membranes were observed between male and female rats in the same group (all P＞0.05).[3H] PK11195 binding activity in spinal cords and platelet membranes were higher in 3-month group than in 24 month group [(213.94±10.65) fmol/mg pro.vs.(50.65± 2.74) fmol/mg pro.,(104.97± 2.24) fmol/mg pro.vs.(56.20±5.36) fmol/mg pro.,respectively,t=51.418,29.041,both P＜ 0.001].There was a positive correlation between [3H]PK11195 binding activity in platelet membranes and in spinal cord synaptosomes (r=0.985,P＜0.001).Conclusions The level of PBRs is gradually decreased in rat spinal cord synaptosomes with ageing.[3H] PK11195 binding activity of platelet membranes can reflect the changes of PBRs in spinal cords.

Objective To evaluate the osteogenic potential of selected exercises and determine which one has the greatest value for the elderly.Methods Twenty healthy old subjects were recruited in the study.Each subject performed the following four exercises in random order:stepping onto a 4-in riser (STEP),sit-to-stand (STS),jumping (JUMP) and marching (MARCH).The subjects performed successively each of the 4 exercises for 1 minute,with an interval of 3 minutes between each.The Vicon action capture system was used to record the peak ground reaction of the subjects during their exercises.The osteogenic index (OI) was calculated by the formula:OI=peak GRF/ (body weight×9.8) × In (number of loading cycles±1).Results JUMP and MARCH had superior OI value (7.52 ±2.06,6.51 ±1.59) than STEP (5.22 ±0.63) among the4 exercises (P＜0.05).STS was found to have the lowest OI (2.23 ± 0.42) in the elderly.There was no significant correlation between the height and OI in JUMP and MARCH (P ＞0.05).Conclusion STEP and MARCH had the higher OI value and could be deemed as the better ways to induce positive effects on bone health in the elderly population.

Radiation pneumonitis (RP) is one of the most common toxicities in patients with lung cancer treated by radiotherapy,which limits the delivered dose and may thus hampers tumor control,then lowers the patients,life quality.Based on the progress of molecular biology,RP may be regarded as a continuous progression of events induced by various cytokines involving numerous cells.Researches on gene polymorphisms indicate different mechanisms in the pathogenesis of RP among different races.Besides,more studies focus on the predictive value of dosimetric parameters such as V20、mean lung dose(MLD) and biological markers such as transforming growth factor-β ( TGF-β1 ).Decreasing use of drugs which may exacerbate RP and increasing use of modern treatments may be beneficial in the prevention.Meanwhile as the respect of drug prevention,more and more emphases are being placed on the target molecule of radiation-induced injury.

Objective To evaluate the safety and therapeutic value of endoscopic sphincterotomy by endoscope to the patients with common duct stones after their gallbladders resected. Methods 158 patients with common duct stones after their gallbladders resected were given the treatments of endoscopic sphincterotomy and nasobiliary drainage in recent 4 years. Results 153 of 158 patients got succeed. The symptoms obviously improved such as jaundice and fever and epigastric distention and so on. As for the postoperative complications, the hyperamylasemia occurred in 85 patients of all patients,and active hemorrhage in 2 patients,and acute pancreatitis in 16 patients,and cholangitis in 5 patients,but no one occurred biliary fistula,no one died,too. Conclusion EST is the best way for us to treat the patients with common duct stones after their gallhladders resected by endoscope,and its curative effect is sure and its safety coefficient is higher.

ObjectivesTo observe correlation between serum vitamin A status and prevalence or severity of NRDS. MethodsRecruited into this study were 166 preterm infants admitted to our neonatal department. The serum concentration of vitamin A was measured, and the prevalence of NRDS at different levels of vitamin A was compared. According to the clinical manifestation and X-rays, there were 30 infants diagnosed as NRDS. Another 30 patients from the rest 133 infants without NRDS were randomly selected as control group according to the gestational ages, then the difference between NRDS group and control group were observed according to gestational ages. The 30 preterm infants with NRDS were divided further into mild group (in-cluding stagesⅠandⅡ,n=18) and severe group (including stageⅢ andⅣ,n=12) according to ifndings chest X-ray, then the difference between these two groups were observed.ResultsIn the 166 preterm infants recruited, 65/166 had serum vitamin A lower than 0.35 μmol/L, in which 14/65 (21.54%) were NRDS patients. Another 93/166 patients had serum vitamin A ranged from 0.35 μmol/L to 0.7 μmol/L, in which 15/93 (16.13%) were NRDS patient. The rest 8/166 had serum vitamin A higher than 0.7 μmol/L, in which 1/8 (12.50%) were NRDS patient. However, the differences between each two groups were not signiifcant. When gestational ages ranged from 34 to 37 weeks, the serum concentrations of vitamin A of NRDS group were lower than that in controls (P<0.05). No signiifcant difference between the serum concentrations of vitamin A and the severity of NRDS were ob-served (P>0.05).ConclusionsThe prevalence of NRDS for those preterm infants lacking of vitamin A was tended to increase. And the late preterm infants (34 w≤ GA <37 w) with vitamin A deifciency are prone to NRDS.