1.Super-selective renal artery embolization in treatment of iatrogenic renal pseudoaneurysm and arteriovenous fistula
Yuefeng HU ; Cheng'en WANG ; Min YANG ; Xiaoqiang TONG ; Jian WANG ; Li SONG ; Haitao GUAN ; Yinghua ZOU
Chinese Journal of Interventional Imaging and Therapy 2017;14(8):460-463
Objective To evaluate the efficacy and safety of super-selective renal artery embolization in treatment of iatrogenie renal pseudoaneurysm and arteriovenous fistula.Methods Twenty-nine patients with iatrogenic renal pseudoaneurysm and arteriovenous fistula underwent renal angiography after ineffective conservative treatment.After identifying the location and characteristic of lesions by DSA,super-selective renal artery embolization was performed.Symptoms and signs,renal function changes before and after embolization and complications were recorded to evaluate the therapeutic effect.Results The technical success rate of super-selective renal artery embolization was 100% (29/29),and clinical success rate was 96.55 % (28/29).The serum creatinine level before and after embolotherapy was (93.26 ± 28.79) mmol/L and (91.51 ± 27.68) mmol/L respectively,and there were no significant differences (t=1.28,P=0.22).No serious complications such as nephrapostasis or renal failure occurred in the study.Conclusion Super-selective renal artery embolization has technically and clinically high success rate with limited effect on renal function.It is a safe and effective therapy method in patients with iatrogenic renal pseudoaneurysm and arteriovenous fistula.
2.Gastric Cancer Stem Cells: Mechanisms and Therapeutic Approaches.
Yan FU ; Peizhun DU ; Jing ZHAO ; Cheng'en HU ; Yunyun QIN ; Guangjian HUANG
Yonsei Medical Journal 2018;59(10):1150-1158
Gastric cancer (GC) is the third leading cause of cancer-related deaths worldwide. GC stem-like cells (GCSCs), with unlimited self-renewal, differentiation, and tumor-regenerating capacities, contribute significantly to the refractory features of GC and have gained increasing attention for their role in GC drug resistance, relapse, and metastasis. Therapies targeting GCSCs seem to be one of the most promising methods to improve the outcomes of GC patients. Extensive investigations have attempted to outline the regulatory mechanisms in GCSCs and to develop GCSCs-targeting therapies with which to diminish GC drug resistance, metastasis and relapse. To the best of our knowledge, there is a lack of reviews summarizing these studies. In this review, we systematically recapitulated findings regarding the regulatory mechanisms of GCSCs, as well as therapies that target GCSCs, hoping to support the development of prognostic biomarkers and GCSCs-targeting anticancer therapies in GC.
Biomarkers
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Drug Resistance
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Hope
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Humans
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Neoplasm Metastasis
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Neoplastic Stem Cells
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Recurrence
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Stem Cells*
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Stomach Neoplasms*