Objective To examine the anticancer effect of a novel histone deacetylase inhibitor (HDACi), JZ004, on colon cancer cells HCT-8 and HT-29, and to investigate the molecular mechanisms of proliferation inhibition and apoptosis induction of cancer cells treated by JZ 004.Methods Colon cancer cells were treated with a series of concentrations of JZ004 .MTT assay was used to detect the proliferation of cancer cells .The cell cycle distribution and apoptosis were deter-mined by flow cytometry .Rhodamine 123 and DCFH-DA were applied to detect the mitochondrial membrane potential (ΔΨm) and reactive oxygen species ( ROS) production.The protein expressions of acetyl-histone H3, p21, cyclin-dependent kinase(CDK)4, Bcl-2, Mcl-1 and Bax were assayed by Western blotting .Results JZ004 was found to inhibit proliferation and induce apoptosis of colon cancer cells in a time-and dose-dependent manner , accompanied by a dose-dependent hyperacetylation of histone H3.JZ004 induced the cancer cell arrest in G 0/G1 phase by increasing the expres-sion level of p21 while CDK4 was downregulated .JZ004 also increased cellular ROS production and reduced ΔΨm by regu-lating the expressions of Bcl-2 family proteins .Conclusion As a novel HDACi , JZ004 effectively inhibits proliferation and increases ROS production to induce apoptosis of colon cancer cells .The results indicate that JZ004 is a potential compound to be developed as an anti-colon cancer agent for clinic application .

Objective:To explore the effect of remote blood glucose management led by specialist nurses on blood glucose, self-management ability and quality of life of type 2 diabetic patients during home rehabilitation.Methods:From January to December 2019, convenience sampling was used to select 218 patients with type 2 diabetes in the First Affiliated Hospital of Xinjiang Medical University. According to the random number table method, the patients were divided into the observation group and the control group, each with 109 cases. The control group conducted conventional blood glucose management, and the observation group implemented remote blood glucose management led by specialist nurses for a total of three months of observation. Both were observed for 3 months. The self-management behavior and quality of life of the two groups of patients before and after the intervention were evaluated with the Diabetes Self-Management Behavior Scale (SDSCA) and the Diabetes Quality of Life Specific Scale (DSQL), and the blood glucose indicators of the two groups before and after the intervention were compared.Results:All 218 cases cooperated to complete all the research contents, and there was no dropout case. After the intervention, the fasting blood glucose, two hours postprandial blood glucose, glycosylated hemoglobin and DSQL score of the observation group were lower than those of the control group, and the SDSCA score was higher than that of the control group. The differences were all statistically significant ( P<0.05) . Conclusions:Compared with conventional blood glucose management, the remote blood glucose management led by specialist nurses can more effectively control the blood glucose of patients with type 2 diabetes, improve the patients' self-management ability and quality of life, and overall increase the management efficiency of patients during home rehabilitation.

Objective:To explore the effect of precision nutrition therapy on the dietary pattern and appetite of patients with type 2 diabetes mellitus (T2DM) .Methods:From September 2018 to September 2019, convenience sampling method was used to select 155 patients with T2DM discharged from the Endocrinology Department of the First Affiliated Hospital of Xinjiang Medical University. All patients were randomly divided into control group (73 cases) and experimental group (82 cases) . Control group received routine nutritional intervention. Based on routine follow-up intervention, experimental group established a patient's personalized data model according to the medical artificial intelligence system for precise nutritional treatment, including the establishment of diabetes diet management prescriptions and intelligent diet intervention. The Dietary Pattern Questionnaire and the Simplified Nutritional Appetite Questionnaire (SNAQ) were used to compare the changes in dietary patterns and appetite before and after intervention between two groups.Results:After three months of intervention, the proportion of patients with reasonable protein, fat, and carbohydrate intake in two groups was higher than that before intervention, and that of experimental group was higher than that of control group, and the difference was statistically significant ( P<0.05) . After three months of intervention, the score of SNAQ of experimental group and control group was (13.20±1.54) and (10.32±1.25) respectively, and the difference was statistically significant ( t=-12.838, P<0.05) . Conclusions:The establishment of a big data model based on a medical artificial intelligence system for precise nutritional therapy can regulate the dietary behavior of patients with T2DM and increase their appetite.

Objective:To explore the effect of exercise prescription intervention with multidisciplinary support on elderly patients with diabetes mellitus accompanied by sarcopenia.Methods:Using the convenient sampling method, a total of 84 patients with diabetes mellitus accompanied by sarcopenia over 60 years old were selected from 6 community health service centers that had long-term cooperation with the First Affiliated Hospital of Xinjiang Medical University from January 2018 to September 2019. They were randomly divided into the observation group and the control group, with 41 cases in each group. The control group received routine nursing management, while the observation group implemented exercise prescription intervention with multidisciplinary support on the basis of the control group, and the intervention period was 12 weeks. The differences in laboratory indexes, limb motor function and Diabetes Specific Quality of Life Scale (DSQL) scores were compared between the two groups.Results:After intervention, glycosylated hemoglobin (5.38±0.67) % and DSQL score (76.35±5.48) of patients in the observation group were lower than those of the control group, and the differences were statistically significant ( t=-9.964, -5.113; P<0.05) . After intervention, serum albumin (35.81±1.86) g/L and limb motor function score (88.94±7.02) of patients in the observation group were higher than those in the control group, and the differences were statistically significant ( t=5.860, 2.501; P<0.05) . Conclusions:Exercise prescription intervention with multidisciplinary support can help elderly patients with diabetes mellitus accompanied by sarcopenia to improve their blood sugar control, quality of life and skeletal muscle quality and function.