Objective:To assess the analgesic effects and side effects of buprenorphine sublingual tablet in dental treatment.Methods:500 cases for dental treatment were selected.Before management of teeth,all the patients took 0.2 mg of buprenorphine sublingual tablet.The VAS score,Kuttner face score and side effects after dental treatment were recorded.Results:The VAS scores of the patients underwent preventive,operative and prosthetic treatments were 3.99?2.34,2.72?1.67 and 2.78?1.55,the Kuttner scores of those 1.98?1.23,2.66?1.04 and 2.03?0.93,respectively.Side effect was not observed in all the patients.Conclusion:Buprenorphine sublingual tablet can relieve the pain in dental treatment.

‘Pathemas in meridians and collaterals’, a new word in stroke, is put forward by CHENG Men-xue. He emphasizes that pathemas in meridians and collaterals plays an important part in syndrome differentiation of stroke. Attention should be paied to meridians and collaterals when we treat stoke. Drugs with function of dispelling wind and removing obstruction in the meridians should be used in the whole process of the stroke.

Objective To compare the clinical effects between simple debridement and debridement and interbody fusion and internal fixation for the treatment of children with spinal tuberculosis.Methods 120 cases of children with spinal tuberculosis,were divided into control group(n =60)and observation group(n =60)according to surgical treatment.The control group was administrated with conventional simple debridement treatment,the observation group was administrated with debridement and interbody fusion and internal fixation,the efficacy and quality of life level of two groups of children were compared after treatment.Results The total effective rate of the observation group was 93.3%,which was significantly higher than 73.3% of the control group(χ2 =7.69,P <0.01);The blood loss,operative time,postoperative complication rate of the observation group were (83.47 ±16.35)mL,(35.38 ± 12.34)min and 6.7%,respectively;which in the control group were (165.12 ±22.31)mL,(62.15 ±21.63)min and 21.7% respectively,the difference were statistically significant(t =19.95,20.34,χ2 =8.17,all P <0.05).The adverse reactions(loss of appetite,pain in the spine)rate of the observation group was 8.3%,which was significantly lower than 30.0% of the control group(χ2 =9.02,P <0.05).Conclusion The comparison with conventional simple debridement therapy,the use of debridement over interbody fusion and internal fixation is effective on treatment in children of spinal tuberculosis,children can speed up the recovery with fewer complications,which should be widely applied.

Objective To analyze the clinical manifestation of thyroid carcinoma in patient with nodular goiter,and explore the effective diagnosis and treatment method.Methods Retrospective analysis was made on patients operated upon for nodular goiter with coexisting diffetentiated thyroid carcinoma.Results Tiny papillary car-cinoma 9 cases,papillary carcinoma 1 1 cases,and follicular carcinoma 1 case.Four Chad cervical lymph node involve-ment,2 cases in the cervical compartment and 2 cases in the central area.We followed up for 10 months to 10 years, all of the patients were survival.Conclusion Early diagnosis can provide scientific basis for surgical treatment.Oper-ation should master the indication and scope,to ensure the satety,impove survival rate.

Objective: To investigate the effect of s urface modification of stearic acid solid lipid nanoparticles with Brij 78 on the body distribution. Me thods: T he stearic acid solid lipid nanoparticles were prepared by “emulsi on-evaperation-solidfied at low temperature" method with two kinds of surfacta nts: Brij 78 and taurocholic acid sodium salt. Groups of five randomly selected Kun Ming mice of both sexes were used for each suspension and for each time point. After injection of each suspension into the tail vein, one group of mice were killed a t e ach time point. Then the blood, liver, spleen, lung, heart, kidney, muscles and fat were removed and the dpm value of 100 μl blood and 50 mg of each tissue was determined. Results: Compared with the nanoparticles taurocholi c acid sodium salt, the AUC (tissue)/AUC(blood) value of to spleen, lung, heart and kidney with the nanoparticles modified with Brij 78 was increased to 1 12.5%, 143.6%, 146.7% and 184.8% respectively. Conclusion: The distribution of stearic acid solid l ipid nanoparticles into the non-RES organs can be increased and the circulating time may be prolonged by modifying the nanoparticle surface with Brij 78.

Five-zang is the nucleus of viscera state doctrine. The nonequilibrium of Five-zang's different properties guides syndrome differentiation and treatment in TCM. This article discusses five-zang's nonequilibrium from lung being a delicate viscus,correlation between lung and five-zang,physiology and pathology of lung and so on. It attaches the importance to five-zang's nonequilibrium and clinical level of syndrome differentiation.

Objective To evaluate the non-invasive cardiac output measurements by electric impedance in critically illpatients. Methods Cardiac output measurements by impedance and Doppler ultrasonography were performed in 38 pa-tients in ICU. Results There was a significant correlation (r =0. 908 ) between impedance and ultrasonography for car-dio output measurement. Conclusion There is close agreement between electric impedance and ultrasonography in themeasurement of cardiac output in the patients. The electric impedance measurement is a noninvasive,feasible, handy, con-tinuous and cheap measurement of cardiac output.

Objective:To investigate the cause and preventive measures of chemotherapy-related death from human malignant neoplasms.Methods:A retrospective study was carried out to evaluate the clinical data of 15 patients with chemotherapy-related death of human neoplasms in 2008.The cause,treatment,survival time after chemotherapy and preventive measures were analyzed.Results:The average age of the 15 patients was 52.4 years,and 5 of them were treated with docetaxel.The mean survival time after chemotherapy was 16.8 days.5 cases presented severe sehematological toxicity, and 2,breath failure.Conclusion:Chemotherapy-related death from human malignant neoplasms was correlated with disease history,age and chemotherapeutic agents,etc.;therefore,no use of docetaxel for patients aged over 60 years or with hepatic and lung diseased history could decrease the chemotherapy-related death.

Objective To investigate the clinical application of vascular endothelial growth factor (VEGF) and nuclear transcription factor(NF-κB)/p50 on diagnosis and prognosis of the abundance of matrix and rich cell type salivary gland pleomorphic adenoma.Methods Fifty cases with parotid pleomorphic adenoma pathological from Jan.2004 to Nov.2004 collected at Affiliated Hospital of Hebei United University and Kailuan General Hospital were selected in this study.There were 25 samples with pleomorphic adenoma of matrix-based abundant salivary gland served as group A,25 samples were cell-based abundant salivary gland pleomorphic adenoma served as group B,and 25 samples were normal salivary gland tissue adjacent to tumor served as control group.The immunohistochemical technology and SP method were applied to detect the expression of VEGF and NF-κB/p50.Results Expressions of VEGF in group A and B were (153.13 ± 60.81) and (954.65 ± 305.79),significantly higher than that in group C (52.46 ± 9.76,P ＜ 0.05).Expressions of NF-κB/p50 in group A and B were (43.40 ± 5.56),(529.79 ± 163.81),significantly higher in that in group C (6.83 ± 1.90,P ＜ 0.05) ; Expressions of VEGF and NF-κB/p50 in group B were higher than that in group A (P ＜ 0.01).There were the positive correlation between EGF and NF-κB/p50 expression in pleomorphic adenoma samples (r =0.9123,P =0.001).Conclusion With the increase in tumor cell components,angiogenesis and cell proliferation activity increase in cases with pleomorphic adenoma.Cases with cell-based abundant pleomorphic adenoma show the malignant transformation tendency compared with cases with matrix-based abundant pleomorohic adenoma.

Objective To achieve millisecond grade precision in the design model of event-related fMRI experiment.Methods The impact factors of time precision were analyzed,and solutions were put forward.Results The parameter of E-Prime(a software dedicated to psychology study) was adjusted to get millisecond precision.Conclusion General computer is very difficult to achieve millisecond grade due to software and hardware factors,but it can be achieved through adjusting the parameter of E-Prime.