1.Therapeutic effect analysis of MSM after highly active antiretroviral therapy in Chongqing
Chao ZHOU ; Zongliang CHEN ; Quanhua ZHOU ; Guohui WU ; Ying ZHOU
Chongqing Medicine 2015;(16):2205-2207
Objective To know basic characteristics of MSM infected with HIV treated by highly active antiretroviral thera‐py(HAART) ,and evaluate therapeutic effect based on the level of CD4+ T cell counts .Methods Basic database of patients were collected from the national AIDS comprehensive data information system ,patients were observed by the retrospective cohort study , and effect indicators were analyzed based on the level of CD4+ T cell counts .The data was analyzed by SPSS18 .0 software .Results A total of 1 758 cases were recruited in this study and the average age was (33 .5 ± 11 .1)years .The component ratio of the CD4+T cell counts <50/μL ,50 to 199/μL ,200 to 350/μL ,> 350/μL were 7 .7% ,27 .6% ,54 .9% ,9 .7% ,respectively .The CD4+ T counts increased and kept among 150 to 250/μL ,250 to 350/μL ,350 to 450/μL ,450 to 550/μL ,respectively after 12 months ,treat‐ment .The rates of viral inhibition were 70 .2% ,81 .7% ,84 .2% ,83 .3% ,respectively after 6 months′treatment .And the cumulative survival rates were 0 .81 ,0 .93 ,0 .98 ,1 .0 after 36 ,months treatment ,respectively .Conclusion HAART on MSM achieves remarka‐ble results .And the early treatment was more beneficial to improve immune function ,reduce AIDS mortality and control the HIV/AIDS epidemic of MSM .
2.Relationship between anomalous pancreaticobiliary ductal junction and biliogenic chronic pancreatitis
Zhiming CHEN ; Ke ZHOU ; Ping WU ; Jue CHEN ; Kai ZHOU
Journal of Regional Anatomy and Operative Surgery 2013;(6):627-628
Objective To study the incidence rate and correlation of anomalous pancreaticobiliary ductal junction( APBDJ) for patients with biliogenic chronic pancreatitis (BCP). Methods From January 2000 to January 2012,the data of 1 373 patients who underwent ER-CP,MRCP or T-Tube cholangiography in which both biliary and pancreatic ducts in our hospital were analyzed retrospectively. Results Bil-iogenic chronic pancreatitis was found in 47 patients,of which 17 patients with APBDJ. The mean (SD) common channel was (19. 3±7. 2) mm in length ( range 11~40 mm) . Conclusion APBDJ may be the important reason of BCP among Chinese patients.
3.Early postoperative enteral nutrition compared with parenteral nutrition in patients with colorectal cancer
Zhiming CHEN ; Ke ZHOU ; Ping WU ; Jue CHEN ; Kai ZHOU
Journal of Regional Anatomy and Operative Surgery 2015;(1):85-86,87
Objective To analyze the effect of different postoperative nutrition:enteral nutrition( EN) and parenteral nutrition( PN) in patients with colorectal cancer. Methods 84 patients with colorectal cancer were collected in this study from Jan. 2012 to Jan. 2014, and they were divided into the EN group (43 cases) and the PN group (41 cases). They were given EN or PN after operation. The nutritional parameters such as ALB, TF and PA were detected before surgery and 7 days after operation, Observe the adverse reaction, time of gastroin-testinal function recovery, infection and costs after operation. Results There was no statistical difference (P>0. 05) in the nutritional pa-rameters and rate of adverse reaction between the two groups. The rate of infection in EN group was lower than that in PN group(P<0. 01), and the time of gastrointestinal function recovery was shorter in EN group compared with that in PN group (P<0. 01). Conclusion EN is better in recovery of gastrointestinal function, and there is less complication compared to PN. EN have clinical application value for patients with gastrointestinal cancer.
4.EXPRESSION OF BRAIN-DERIVED NEUROTROPHIC FACTOR IN DEAFFERENT SPINAL CORD DORSAL HORN OF CAT
Lihua CHEN ; Liangfang WU ; Xue ZHOU
Chinese Journal of Neuroanatomy 2000;16(3):269-272
To investigate the expression change of BDNF in lamina II of spinal cord from partial deafferented cats, L6 segmentsof spinal cord from 20 adult male cats (5 normal cats, 15 unilateral L6 spared roots cats allowed to survive 3 d, 6 d and 12 d re-spectively) were stained with immunohistochemical technique. The results showed: BDNF positive products were mainly dis-tributed in nerve terminals, varicosities and few neurons of spinal cord lamina II in normal cat. After operation, the density ofpositive nerve terminals and varicosities began to decrease on the third day, reached the lowest level on the 6th day and recoveredto normal level on the 12th day on operated side. But the number of BDNF neurons showed no obvious change. The authors sug-gest that the decreased density of BDNF positive products in lamina II on the 3rd and 6th day was related with the degenerationof the nerve fibers and varicosities after section of the adjacent dorsal roots. On the 12th day, the remaining L6 dorsal roots un-derwent collateral sprouting compensatoryly and reestablished functional connection with target neurons. Therefore, BDNF maybe involved in the normal physiological function and the plasticity of spinal cord after damage.
5.Value of chronotropic index in identifying coronary artery disease
Qingsong ZHOU ; Qiaghua WU ; Jing CHEN
Clinical Medicine of China 2009;25(11):1142-1144
Objective To assess the diagnostic value of chronotropic index in identifying coronary artery disease (CAD). Methods One hundred and sixty two patients with suspected CAD were referred for a routine treadmill exercise electrocardiogram and subsequently underwent selective coronary angiography within 3 weeks. The magnitude of ST segment depression and chronotropic index were measured by a computerized ECG system. CAD was defined by coronary angiography. Results In detecting CAD, the sensitivity was 70. 1% versus 60.9% (P< 0.05) ,the specificity was 84.0% versus 73.3% (P<0.05), and the accuracy was 76.5% versus 66.7% (P< 0.05) by chronotropic index and standard electrocardiographic test criteria. The value of Kappa statistic for chrono-tropic index consistency in our experiment was 0.534(>0.4). The number of diseased vessels was correlated with the mean value of chronotropic index. The chronotropic index decreased from 0.88±0.09 in patients without coro-nary disease to 0.68±0.06 in those with 3 vessels involved (P<0.01). A more closed relationship was found be-tween chronotropic index and lesion in the fight coronary artery. Conclusions Chronotropic index is possibly a valu-able positive index for the diagnosis of CAD. The sensitivity,specificity and accuracy of chronotropic index are signif-icandy higher than those of standard electrocardiographic test criteria in identifying CAD.
6.Canonical correlation of professional stress,social support and somatic symptoms of sub-health status in Ningbo normal senior school teachers
Yonglong ZHOU ; Wenqiang WU ; Weicheng CHEN
Chinese Journal of Behavioral Medicine and Brain Science 2009;18(3):271-272
Objective To explore the relationship of professional stress,social support and somatic symptoms of sub-health status of Ningbo normal senior school teachers. Methods 128 normal senior school teachers were selected and investigated by professional stress scale,social support scale and somatic symptoms of sub-health status scale, and canonical correlation analysis was used. Results The canonical correlation coefficient were 0.563, 0.471( P <0.01) with the existence of social support variable. The somatic symptoms of sub-health status would be greater with the rise of their professional stress and the decline of their social support. The canonical correlation coefficient was 0.497( P <0.01) with the elimination of social support variable. The factor loading of "examination pressure","professional burden" and "career expectation" in canonical variable ξ add to 0.801,0.855,0.726 respectively. The factor loading of "feeling of fatigue","sleep disorders" in canonical variable η add to 0.774,0.859 respectively. Conclusion The social support have adjustment function between the professional stress and somatic symptoms of sub-health status.
7.Two-dimensional Strain Imaging of Ultrasound in Evaluation of Myocardial Systolic Function of Left Ventricle in Patients with Acute Myocardial Infarction.
Liyuan WU ; Li ZHOU ; Minhua CHEN
Journal of Medical Research 2006;0(02):-
Objective To evaluate left ventricular function in patients with acute myocardial infarction and to investigate the clinical value by two-dimensional strain imaging of ultrasound.Methods Study population was consisted of 28 patients with acute myocardial infarction of wall anterior and 30 healthy subjects.Images were recorded from the left ventricular the apical 4-chamber view,apical 3-chamber view,apical 2-chamber view respectively.Two-dimensional strain and strain rate were measured in the left ventricular segments using two-dimensional strain software.We analyzed that relationship between two-dimensional the global peak systolic strain,global strain rate and left ventricular end systolic volume(LVESV),left ventricular end diastolic volume(LVEDV),wall motion score index(WMSI),left ventricular ejection fraction(LVEF).Results ①Infarct segments in myocardial infarction group showed significant reduction of peak systolic strain as compared with normal group(P
8.Assessment on Disinfection Effect in Hospitals at Province Level in Hunan, China in 2001-2005
Lijun ZHOU ; Chuanye WU ; Guiqiu CHEN
Journal of Environment and Health 1992;0(04):-
Objective To know the status of disinfection conducted in the hospitals at province level in Hunan province aimed to make the intervention strategy for prevention and control of diseases transmission. Methods The related items of hospitals at province level were examined and evaluated according to the national standards such as GB15982-1995 Hygienic Standard for Disinfection in Hospital, GB15981-1995 Evaluating Method and Standard for the Efficacy of Disinfection and Sterilization, GB8987-1996 Requirements for Hospital Sewage Discharge, GB18466-2001 Requirements for Medical Organization Sewage Discharge, GB15980-1995 Hygienic Standard of Disinfection for Single Use Medical Products and Technical Standard for Disinfection (2002). Results As for the disinfection effect in the present investigation, the total qualified rate was 90.10%, the annual qualified rate was increasing. Conclusion The surveillance of hospital disinfection is a long-term task, to supervise and improve the hospital disinfection is necessary to ensure patient and society safety.
9.Randomized Double-blind Clinical Trial on Efficacy of Xuezhikang Capsule on Hyperuricacidemia and its Safety
Bicang CHEN ; Qiuying WU ; Yi ZHOU
Chinese Journal of Information on Traditional Chinese Medicine 2006;0(08):-
Objective To assess the efficacy of Xuezhikang capsule on hyperuricacidemia and its safety. Methods The study was designed as a random, double-blind placebo controlled clinical trial. 80 hyperuricacidemia patients were divided randomly into test group and control group (40 in test group and 40 in control group). The course of treatment was 28 days. Results 75 patients finished the trial (38 in test group and 37 in control group). After 28 days of treatment, the differences in reduction of UA, XOD, FINs, Homa-IR, TC, TG, Lp, CRP, ET, ?2-MG and elevation of HDL of the test group were statistic significance. No side effect was found in the trial. Conclusion Xuezhikang capsule has good clinical effect and safety in the treatment of hyperuricacidemia.
10.Efficacy of CSII for diabetes with cholecystitis during peri-operation period
Yan ZHOU ; Dafang WU ; Yu CHEN
Chinese Journal of Diabetes 1994;0(01):-
During the period of peri-operation on gallbladder,T2MD patients with calculous cholecystitis were randomly divided into groups of continuous subcutaneous insulin infusion(CSII,n=32),multiple subcutaneous insulin injection(MSII,n=48) and OHA(n=64).It is found that CSII has better glucose control than MSII and OHA.