1.Clinical study on small incision lenticule extraction surgery for super high myopia
International Eye Science 2017;17(6):1130-1132
AIM: To investigate the clinical effect of small incision lenticule extraction (SMILE) for super high myopia.METHODS: Totally 64 cases (128 eyes) patients with super high myopia, were randomly divided into observation group and control group, 32 cases (64 eyes) in each group.The two groups were separately treated with SMILE or femtosecond laser LASIK (FS-LASIK).We calculated the effectiveness index and safety index by contrastive observation of clinical effects in all patients included uncorrected visual acuity, best corrected visual acuity and postoperative spherical equivalent at preoperative and postoperative 1d, 1wk, 1, 3 and 6mo.RESULTS: The safety index: the observation group and the control group at 6mo after operation were respectively 1.10±0.10 and 1.08±0.12, the difference between the two groups was not statistically significant (P>0.05).The validity index: the observation group and the control group at 6mo after operation were respectively 1.08±0.12 and 1.06±0.14 and there was no significant difference between the two groups (P>0.05).Postoperative spherical equivalent at 6mo in the observation group was 0.09±0.36D, that in the control group was 0.36±0.46D.After 6mo, the count of spherical equivalent refraction within ±0.50D were 58 eyes (90.1%) in observation group and 49 eyes (76.6%) in the control group, within±1.0D were 64 eyes (100%) and 60 eyes(93.8%).CONCLUSION: SMILE is safe and effective in the treatment for super high myopia.The postoperative visual acuity and diopter can be stabilized earlier by comparing with FS-LASIK.
2.A research on clinical literature of cupping therapy
Chunyan LI ; Bo CHEN ; Xia LI ; Zelin CHEN ; Yi GUO
International Journal of Traditional Chinese Medicine 2012;34(6):539-541
This paper evaluates the quality of clinical literature on cupping therapy,analyzes the key factors that influencing the effects of cupping therapy,studies the operation position,tools,accompanied therapy,cupping,cupping frequency,course and other factors in the clinical application of cupping therapy,aiming to provide reference for clinical practice.
3.Analysis of LDH in Radiotherapy-related typing of nasopharyngeal carcinoma
Kuiyu GONG ; Chen CHEN ; Suping GUO ; Yunfei XIA
Chinese Journal of Radiation Oncology 2015;24(1):55-59
Objective This aim of this study was to understand the distribution of pretreatment serum LDH in NPC of each radiotherapy-related typing,and its relationship with prognosis.Methods We collected the pretreatment data of LDH in 2 665 newly diagnosed NPC who underwent radical radiotherapy between January 1,2000 and December 31,2005 at Sun Yat-sen University Cancer Center.Pretreatment serum LDH levels and survival analysis were analyzed in four kinds of radiotherapy-related typing of NPC.Results Distribution of radiotherapy-related types of 2 665 NPC were 74.6% (1 987 cases),15.1% (404 cases),8.6% (229 cases),1.7% (45 cases) for Types Ⅰ (no primary and regional recurrence and no distant metastasis),Ⅱ (primary or regional and no distant metastasis),ⅢⅡ (no primary and regional recurrence,and distant metastasis),Ⅳ (primary or regional recurrence,and distant metastasis),respectively.Increased LDH patients Ⅰ,Ⅱ,Ⅲ,Ⅳ-type proportion were:9.6% (191/1 987),15.8% (64/404),18.8% (43/229),35.6% (16/45).274 cases of type Ⅲ and Ⅳ,there were 81 cases of liver metastasis,which increased LDH levels in 34 cases,accounted for 42%.Total follow-up rate was 95.2%.The OS,LRFS,and DMFS curves for the increased LDH level group and the normal LDH level group was significant (P =0.000,0.000,0.000).Further analysis showed that the above main difference caused by the type Ⅱ (P =0.000).Conclusions Pretreatment levels of serum LDH are associated with radiotherapyrelated typing of NPC,particularly associated with type Ⅲ and type Ⅳ liver metastasis.And mainly type Ⅱ has poor prognosis.
4.Clinical and prognostic analyses of 77 childhood non-Hodgkin's lymphoma.
Xia GUO ; Yi-Ping ZHU ; Chen-Yan ZHOU
Chinese Journal of Hematology 2012;33(9):778-780
Adolescent
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Child
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Child, Preschool
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Female
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Humans
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Infant
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Lymphoma, Non-Hodgkin
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diagnosis
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pathology
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therapy
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Male
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Prognosis
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Retrospective Studies
6.Relevant factors analysis of hysterosalpingography countercurrent
Xia WANG ; Yuanyuan CHEN ; Qinglu GUO ; Xiaoli WANG ; Chaoxiang YANG
Journal of Practical Radiology 2016;32(3):426-428
Objective To study on the factors of countercurrent occured in hysterosalpingography to improve the understanding of countercurrent.Methods 180 patients who underwent hysterosalpingography due to infertility were recruited,and 63 of them who were involved in countercurrent in the process of hysterosalpingography were analyzed statistically.Results The single factor analy-sis demonstrated that such four factors of primary/secondary infertility,menstrual clean days,tubal obstruction or not,and depth of cannula were associated with countercurrent,while Logistic regression analysis indicated that the factors of menstrual clean days, tubal obstruction or not,and depth of cannula during the hysterosalpingography operation were closely related.Conclusion Counter-current are caused by the comprehensive impact of several comprehensive factors like menstrual clean day,tubal obstruction or not, and cannula operation.Therefore adequate preparation should be made before and during the operation,to reduce the occurrences of countercurrent.
7.Protective Effects of Cordyceps Sinensis from Different Habitats on Acute Injury of Hepatic Tissue Induced by Carbon Tetrachloride
Chen WEI ; Guo XIA ; Du GUANG ; Gong XUEPENG ; Sun YUANYUAN
China Pharmacist 2015;(8):1277-1279
To study and compare the protective effects of Cordyceps sinensis from different habitats on acute injury of hepatic tissue induced by carbon tetrachloride ( CCl4 ) . Methods:The rat model of acute injury of hepatic tissue induced by CCl4 was established. The biochemical indicators of alanine aminotranferease ( ALT) and aspartate aminotransferease ( AST) in the serum and superoxide dismutase ( SOD) and L-glutathione( GSH) in the liver tissue were detected, and the liver tissue HE staining was used for the histopathology determination. Results:Compared with those in the model group, the levels of AST and ALT in the serum were sig-nificantly reduced, the levels of SOD and GSH in the liver tissue were notably increased, and the necrosis of liver cells was improved in Cordyceps sinensis groups at low, medium and high dose from different habitats (P<0. 05), however, the differences between the two different habitats were not significant (P>0. 05). Conclusion: Cordyceps sinensis from Qinghai and Tibet shows some positive differences in the protective effect on the acute chemical liver injury induced by CCl4 in rats,however, the differences are not remarka-ble.
8.Protective Effects of Cordyceps Sinensis from Different Origins on Acute Renal Injury Induced by Gentami-cin Sulphate
Wei CHEN ; Xueyuan ZHANG ; Yuancai LIU ; Guang DU ; Xia GUO
China Pharmacist 2015;18(12):2042-2045
Objective:To investigate the protective effects of Cordyceps sinensis from Tibet and Qinghai on acute renal injury in-duced by gentamicin sulphate ( GM) . Methods:The rat model of acute renal injury induced by GM was established. The biochemical indicators including blood urea nitrogen ( BUN) and serum creatinine ( Scr) in serum and NAG enzyme and urine total protein in urine were detected. HE staining was used to observe the pathologic changes in kidney. Results:Compared with those in the model group, the levels of BUN and Scr in serum and NAG enzyme and urine total protein in urine were significantly reduced in the Cordyceps sinen-sis groups, and kidney cells necrosis was improved in the Cordyceps sinensis groups at low, medium and high dose (P<0. 05), how-ever, the difference between the Cordyceps sinensis groups with different habitats were not significant (P >0.05). Conclusion:Cordyceps sinensis from Qinghai and Tibet both have protective effect on acute kidney injury induced by GM in rats, and the difference between them is not remarkable.
9.Polymorphism of CDI4 gene promoter but not Toll-like receptor 4 gene is associated with colorectal cancer in Chinese patients
Li-Shan CHEN ; Qiu-Sha GUO ; Bing XIA ;
Chinese Journal of Digestion 2001;0(11):-
Objective To investigate an association between Toll-like receptor(TLR)4 Asp299Gly or CD14 C-260T polymorphisms and colorectal cancer in Chinese patients.Methods By a method of polymerase chain reaction-based restriction fragment length polymorphism(PCR-RFLP), TLR4 Asp299Gly and CD14 C-260T polymorphisms in unrelated 110 patients with colorectal cancer and 160 healthy controls in Chinese Han race population were genotyped.Results Significant differences of CD14 genotypes were found between healthy controls and the patients with colorectal cancer.The fre- quency of the CC genotype in healthy controls was extremely lower than that in the group of colorectal cancer(15.6% vs.31.8%,P=0.0027,OR=0.3968,95%CI:0.2209-0.7129)while the frequency of the CT genotype in healthy controls was significantly higher than that in the group of colorectal cancer (48.1% vs.30.9%,P=0.0056,OR=2.074,95%CI:1.246-3.452).No TLR4 Asp299Gly mutant genotype was detected in any patients and healthy controls in Chinese Han population.Conclusion The polymorphism of CD14 C-260T but not TLR4 Asp299Gly is associated with colorectal cancer in Chinese patients.
10.Assessment of left atrial function by speckle tracking imaging and real-time three-dimensional echocardiography in patients with essential hypertension
Juan XIA ; Ruiqiang GUO ; Jinling CHEN ; Qing ZHOU
Chinese Journal of Ultrasonography 2010;19(1):8-11
Objective To evaluate left atrial(LA) function in essential hypertensive patients by speckle tracking imaging (STI) and real-time three-dimensional echocardiography (RT-3DE).Methods Thirty seven patients with essential hypertension were divided into normal geometric left ventricle(LV) group (LVN, n = 17) and remodeling geometrc LV group (LVR,n = 20).Twenty-six healthy participants were also include.The strain rate curve was auquired in each LA segment (anterior, posterior, lateral, inferior and septal) by STI. The LV mass, LA maximal, minimal and pre-systolic volume (LAVmax, LAVmin and LAVp), LA passive ejection fraction (LAPEF), LA active ejection fraction (LAAEF) were measured by RT-3DE. Results ①Compared with the control group, the mean peak systolic strain rate(mSR_S) in LVN group was lower(P <0.05), and the mSR_S, mean peak early diastolic strain rate(mSR_E) in LVR group were reduced (P <0.01, P<0.05), and the mean peak late diastolic strain rate (mSR_A) in LVR group was increased (P<0.01).②Compared with the control group,the LAVmax, LAVmin and LAV_P all increased in LVN and LVR group(P <0.05 or P <0, 01), the LAPEF was degraded (P<0.05),and the LAAEF was increased (P<0.05) in the LVR group.③A significant relation between mSR_E and LAPEF(r = 0.788, P <0.01), mSR_A and LAAEF(r = 0.804, P<0.01) could be found in the LVN and LVR group. Conclusions STI and RT-3DE may play important roles in the evaluation of left atrial function. The deformation ability of LA wall may decrease before left ventricular remodeling and it showed a significantly positive correlation with LA ejection function in patients with essential hypertension.