Objective To investigated the efficacy of minimally invasive technique combined with anterolateral thigh flap in repairing skin and soft tissue defects of leg and foot.Methods Anterior thigh flap was used to repair 20 cases of skin and soft tissue defects of leg and foot,the lesions defect area was 3.9 cm × 7.4cm-11.4 cm × 20.6 cm.Given the appropriate minimally invasive techniquesurgical treatment,the effect of follow-up was observed after operation.Results The supply valve area healed.The postoperative flaps of 20cases of patients all survived,no vascular crisis occurred.The color of skin flap was normal,close to normal skin color,and the elasticity of the skin was good,no crack,no fat,no pigmentation and other complications occurred,and no effect on shoes and ankle joint activities.Excellent and good rate of overall assessment flap was 90％(excellent in 12 cases,good in 6 cases);excellent and good rate of Mazur ankle function evaluation was 95％(excellent in 12 cases,good in 7 cases).Conclusion The minimally invasive technique combined with anterolateral thigh flap is a more ideal method to repair the leg and foot soft tissue defects.

Objective To discuss the clinical manifestation and diagnosis of lymphomatous infiltration of the lung.Methods Clinical informations of 17 cases of lymphomatous infiltration of the lung were assessed.Results of 78 patients with malignant lymphoma,17 patients were infiltrated in lung.3 cases were Hodgkin's disease,14 cases were non -Hodgkin's lymphoma.All cases were advanced patients.Survival time of 1 patient was more than 5 years.Survival time of 1 patient which was the shortest was 2 months.Conclusion Patients with lymphomatous infiltration of the lung are not rare.The clinical symptoms and signs are not typical,image diagnosis is the main part in diagnosis of lymphomatous infil- tration of the lung.

Objective:To observe the influence of ischemia/reperfusion(simulated by anoxia) on the characteristics of K~(+) channels in renal tubular epithelial cells.Methods: Healthy renal tubule epithelial cells were divided into normal control group(cultured in serum-free RPMI 1640 medium),anoxic group(treated with antimycin A + serum-free RPMI 1640 medium),and oxidative stress group(H_(2)O_(2)+ serum-free RPMI 1640 medium)(n=15).The whole-cell patch clamp technique was used to examine the characteristics of K~(+) channels in renal tubular epithelial cells.Results: The transmembrane K~(+) current in tubular epithelial cells was voltage-dependent and could be blocked by K~(+) channel blocker Ba~(2+).The transmembrane potential levels in anoxic group and oxidative stress group were remarkably higher than that in normal control group(P

0.05)and the treatment costs were 1 104.60 yuan,2 049.24 yuan and 3 247.99 yuan,respectively(P

As the most popular simplified model of the optical imaging system, the acquisition of the Gaussian point spread function (PSF) parameter is one of the hotspots and key points on which people do research in the field of image restoration. Based on the idea by which there exists deterministic mathematical relationship between Gaussian OTF feature points as well as its parameter and the frequency representation of the image in an existed literature, we proposed an automatic, accurate, stable, and improved approach. This method is able to give prominence to the related calculation feature by a Gaussian convolution and degeneration operation and finally realize the automatic esti mation of PSF parameter of a microscopic image. Experiments have proved that a good restoration result can be achieved utilizing the estimated PSF by the present method, which is of considerable application and reference value in restoration of other sorts with Gaussian approximate PSF model or 3D microscopic image restoration.
Algorithms ; Humans ; Image Interpretation, Computer-Assisted ; Imaging, Three-Dimensional ; Microscopy ; Models, Theoretical ; Normal Distribution

Stromal cell-derived factor-1(SDF-1)is an early cell growth factor which belongs to a subfamily of chemokines.The CXCR4 is SDF-1 receptor.The SDF-1 interacting with CXCR4 plays important roles in physiological and pathological processes such as hematopiesis, stem cell homing,angiogenesis and leukemic cells infiltrating.To study the expression of CXCR4 in leukemia and the relationship between CXCR4 and leukemic cells infiltration can add indicators for leukemic MIC diagnosis of immunology indexes and have great significance to take molecule targeted therapy for preventing leukemia from infiltration or relapse as well.

BACKGROUND:The implantable artificial pacemaker that needs long-term wear is in direct contact with human body tissue, and thus, biocompatibility of the materials is very important. OBJECTIVE:To investigate the material progress and material-related complications of implantable artificial pacemakers. METHODS:Articles related to implantable artificial pacemaker materials and related complications were searched in Wanfang database and PubMed database from 2000 to 2015. The keywords were pacemaker; materials; pacemaker leads; pacemaker electrode; complication in Chinese and English, respectively. Finaly, 27 articles were included and summarized. RESULTS AND CONCLUSION: The implantable artificial pacemakers are in direct contact with the body tissues through the titanium alloy shell covering the pulser, the electrode wire covering the silicone, polyurethane, epoxy resin, and the electrode materials (including carbon, platinum-iridium alloy, Elgilog alloy). These materials have good physical and chemical properties as well as good cytocompatibility, electrophysiological compatibility and blood compatibility with the human body that have been confirmed in the past decades. However, material-related complications often occur, such as contact dermatitis, wire breakage, dislocation, cardiac perforation, venous thrombosis and tricuspid regurgitation along the wire, capsular infection and hematoma when placing the pulser. With the rapid development of today's microelectronic technology, research on the modification of pacemaker materials and the pacing system has been ongoing and has made considerable progress. Moreover, wireless pacemaker development and clinical application may be the future direction of development.

OBJECTIVE:To discuss the health risk links involved in self-medication of Chinese urban residents. METHODS: Based on literature study and the experts consultation, the high risk links of the self-medication were defined according to the process of self-medication behavior and the probability of the health harm involved in the self-medication behavior, and the intervention suggestions were put forward for the health risks. RESULTS & CONCLUSIONS: The health risk links involved in self-medication of Chinese urban residents appear as 6 links include self-diagnostic error, incorrect drug choice, failing to understand or follow drug package inserts in taking drugs, irrational drug use, unaware of the drug contraindication, disregarding the physiological particularity of the special drug users. Carrying out education on self-mediation and behavior management among the residents, and reinforcing the government control are the effective ways to reduce the health risk of self-medication.

Image interpolation is often required during medical image processing and analysis. Although interpolation method based on Gaussian radial basis function (GRBF) has high precision, the long calculation time still limits its application in field of image interpolation. To overcome this problem, a method of two-dimensional and three-dimensional medical image GRBF interpolation based on computing unified device architecture (CUDA) is proposed in this paper. According to single instruction multiple threads (SIMT) executive model of CUDA, various optimizing measures such as coalesced access and shared memory are adopted in this study. To eliminate the edge distortion of image interpolation, natural suture algorithm is utilized in overlapping regions while adopting data space strategy of separating 2D images into blocks or dividing 3D images into sub-volumes. Keeping a high interpolation precision, the 2D and 3D medical image GRBF interpolation achieved great acceleration in each basic computing step. The experiments showed that the operative efficiency of image GRBF interpolation based on CUDA platform was obviously improved compared with CPU calculation. The present method is of a considerable reference value in the application field of image interpolation.
Algorithms ; Image Processing, Computer-Assisted ; Imaging, Three-Dimensional ; Normal Distribution ; Software

Hyponatremia is the most common electrolyte abnormality in hospitalized patients,which could be attributed to many factors.Antidiuretic hormone plays an important role in the development and progression of hyponatremia.It has been reported that estrogen affects antidiuretic hormone level,the number and sensitivity of related receptors,and effects of antidiuretic hormone,resulting in gender difference in occurrence and outcome of hyponatremia.