Objective To compare the clinical effect of different doses of oxycodone on endotracheal intubation during general anesthesia induction period.Methods Ninety-five patients with endotracheal intubation general anesthesia were selected as the research subjects,and the patients were randomly divided into group A,group B and group C.31 patients in group A received intravenous administration of oxycodone 0.20mg/kg,32 patients in group B received intravenous administration of oxycodone 0.25mg/kg,and 32 patients in group C received intravenous administration of oxycodone 0.30mg/kg.The adrenaline,norepinephrine,dopamine concentration,as well as mean arterial pressure and heart rate at different time points were compared among the three groups.Results The mean arterial pressure and heart rate at T0 time point were decreased to varying extent compared with those at T1 time point(t =23.618,7.412;22.928,9.063;32.636,9.422,P =0.000,0.000;0.000,0.000;0.000,0.000).The heart rate,mean arterial pressure at T2,T3 and T4 time points in group A were increased compared with T0 time point (t =13.834,6.506,7.015;17.604,14.796,16.323,P =0.000,0.000,0.000;0.000,0.000,0.000).The adrenaline,norepinephrine and dopamine at T2,T3 and T4 time points in group A were increased compared witb T0 time point (t =121.662,64.533,15.687;31.498,16.933,9.286;39.712,116.049,147.102,P =0.000,0.000,0.000;0.000,0.000,0.000;0.000,0.000,0.000).The heart rate,mean arterial pressure,adrenaline,norepinephrine and dopamine at T2,T3 and T4 time points in group B and group C were decreased significantly compared with those in group A (t =19.586,31.972,16.844,27.087;14.046,14.822,15.377,23.826;7.756,14.396,13.268,23.342,100.573,1 04.010,37.612,38.892,107.377,117.969;56.135,56.757,24.223,25.300,95.057,82.088;22.878,25.731,5.532,5.934,134.763,83.628,P =0.000,0.000,0.000,0.000,0.000,0.000;0.000,0.000,0.000,0.000,0.000,0.000;0.000,0.000,0.000,0.000,0.000,0.000;0.000,0.000,0.000,0.000;0.000,0.000,0.000,0.000;0.000,0.000,0.000,0.000),and the differences were statistically significant (all P ＜ 0.05).Conclusion During the induction of general anesthesia,the appropriate dose of oxycodone in patients with endotracheal intubation was 0.25mg/kg,which could effectively maintain the hemodynamic stability,such as mean arterial pressure,and could reduce the stress response.

Objective To investigate the relationship between plasma P substance(SP),atrial natriuretic peptide(ANP) and renal function in chronic renal failure(CRF).Methods SP and ANP were measured by radioi m munoassay in normal control and CRF before and after hemodialysis(HD),serum creatinine(Cr) was determined simultaneously.Results SP before HD was significantly higher than that of control(P

Objective To evaluate the effect of oral levothyroxine plus intrathyroidal injection of dexamethasone on conversion of subclinical hypothroidism caused by Hashimoto's thyroiditis.Methods 80 subjects with Hashimoto thyroiditis were randomly divided into 2 groups.Subjects in levothyroxine group(40 cases) were treated with oral levothyroxine sodium,subjects in dexamethasone group(40 cases) were treated with oral levothyroxine plus intrathyroidal injection of dexamethasone.Serum free triiodothyronine(FT_3),free thyroxine(FT_4),sentient thyrotropin(sTSH) and other parameters were evaluated before treatment and after treatment in patients with Hashimoto's thyroiditis.Results The content of FT_3,FT_4 after treatment were obviously higher than that before treatment(t=2.123,P

Objective To study the status of telomerase activity during the development of thyroid tumors,and to determine whether telomerase activity can be used clinically as a molecular marker in the differential diagnosis of thyroid cancer.Methods Telomerase activity was measured in 37 thyroid carcinomas,33 benign thyroid lesions and 30 normal thyroid tissue samples by means of telomerase repeat amplification procedure-polymerase chain reaction(TRAP-PCR).The assay was also applied to 15 fine needle aspirates(FNAs) of thyroid carcinomas to test its sensitivity.Results Thirty-one of 37 thyroid carcinomas(83.8%),7 of 33 benign thyroid lesions(21.2%),and 4 of 30 adjacent normal thyroid tissue asmples expressed telomerase activity,15 FNAs also had positive telomerase activity,just as their corresponding tissue specimens.The quantitative analysis showed that the telomerase activity was significantly higher in thyroid carcinomas than that in benign thyroid tissue samples.And medullary carcinomas and anaplastic carcinomas had higher levels of telomerase activity than papillary carcinomas.Conclusion Telomerase activity is a good marker for thyroid carcinomas.The quantitative TRAP-PCR might have more potential application in the differential diagnosis of tumors and the estimation of tumor progression and prognosis.And this sensitive assay could become a useful new modality for supplementing microscopic cytopathology in the detection of cancer cells in small tissue samples and FNAs.

Algorithms ; Biopsy, Needle ; Child ; China ; Humans ; Lung ; diagnostic imaging ; pathology ; Lung Diseases, Interstitial ; classification ; diagnosis ; etiology ; Mass Screening ; Societies, Medical ; Tomography, X-Ray Computed

Animals ; Humans ; Neoplasms ; metabolism ; pathology ; Signal Transduction ; physiology

Aortic Aneurysm, Abdominal ; therapy ; Humans

Child ; Humans ; Lung Diseases, Interstitial ; diagnosis

OBJECTIVE:To observe clinical efficacy and safety of tigecycline combined with isepamicin in the treatment of multidrug-resistant Acinetobacter baumannii pneumonia. METHODS:70 patients diagnosed as multidrug-resistant A. baumannii pneumonia were selected and randomly divided into control group and observation group,with 35 cases in each group. Both groups received routine treatment oxygen therapy or mechanical ventilation,anti-hypertension,hypoglycemic therapy. Control group was given Cefoperazone sulbactam for injection 3 g added into Sodium chloride injection 100 ml,ivgtt,qid. Observation group re-ceived Tigecycline for injection 100 mg,decreasing to 50 mg added into Sodium chloride injection 250 ml,ivgtt,bid,combined with Isepamicin sulfate injection 400 mg added into Sodium chloride injection 250 ml,ivgtt,qd. The time of body temperature re-turn to normal,pulmonary rale disappearance,chest X-ray shadow disappearance and leucocyte return to normal were observed in 2 groups as well as serum inflammatory factor level before and after treatment;total effective rate,bacterial clearance rate and ADR were compared between 2 groups. RESULTS:The time of body temperature return to normal,pulmonary rale disappearance, chest X-ray shadow disappearance and leucocyte return to normal in observation group were significantly shorter than in control group,with statistical significance(P<0.05). There was no statistical significance in serum inflammatory factor between 2 groups before treatment(P>0.05). The serum inflammatory factor of 2 groups decreased significantly after treatment,and the observation group was significantly lower than the control group,with statistical significance(P<0.05). Total effective rate and effective bacte-rial clearance rate of observation group were 85.7% and 82.9%,which were significantly higher than those of control group (62.9% and 60.0%),with statistical significance(P<0.05). There was no statistical significance in the incidence of ADR between 2 groups(P>0.05). CONCLUSIONS:Tigecycline combined with isepamicin is effective for multidrug-resistant A. baumannii pneu-monia,and can improve clinical symptom,control inflammation reaction,having high sterilization with good safety.

Objective To investigate the effect of Ruigan (L-omithine-L-aspartate) on liver function of perio-perative treatment. Methods 58 patients with obstructive jaundice and having been done operation were randomly di-vided into two groups:ruigan group (cured group,32 cases) and routine hugan group (control group,26 cases). The levels of liver function and endotoxin were detected when being in hospital, before operation and after operation re-spectively. Results Treatment with ruigan could improve the liver function in perioperation, which has significant difference when compared to the control group (P < 0.05).. Ruigan could reduce the level of endotoxin before and af-ter operation (P < 0.05) and improve endotoxaemia in obstructive jaundice. Conclusion Ruigan would improve the liver function and the endotoxaemia in the perioperative obstructive jaundice.