Objective To study the effect of individual and environmental factors of diabeties on their glycemic and lipidic metabolism. Methods While educating diabeties with diabetic informations, we inguired their individual data questionnaires. According to their diabetic periods,cultural levels,compliance to their doctors,daily work times and ocupations respectively,we grouped these patients and compared their fasting and postprandial glycemia (FBG & PBG), GHb,serum lipids and serum uric acid (BUA). Results Among 2 856 diabetic patients,the type I was about 4. 9% and the type Ⅱ about 95. 1% ; the family patients was about 9. 91% and the overweight about 44. 29K. According to patients' compliance to their doctors,blood glucose,GHb and lipids and BUA was lower in absolute compliance group than the basical group or the non compliance one (P＜0. 02),and the levels of glycemia and GHb and TG all related to their compliance (respectively r=- 0. 059, - 0. 055, - 0. 075, - 0. 063 ; and P＜0. 05, 0. 05, 0. 01, 0. 025 ). Considering the diabetes periods,the 1-5 year metabolic control of group was best (P＜0. 02) and the 5- 10 year and above 10 year metabolic control groups were better than the group within one year (P ＜0. 05). To patients' cultural levels, the metabolic control senior or higher middle school groups was better than the junior middle school or lower (P＜0. 05). Thinking their daily work time and occupation,the metabolic control of groups working more than seven hours was worst (p respectively less than 0. 05 and 0. 02). Conclusion diabetic patients' individual and environmental factors are all affecting their metabolic control,among them the complicance is most effective.

In order to make early diagnosis of the ischemic heart disease in the aged NIDDM patients. 500 patients underwent a series of examinations including maximal plate exercise with 59M Tc-MIBI ECT myocardiography. maximal plate exercise ECG and 24-hour ambulatory ECG. The serum lipid. glucose and insulin levels, daily urine protein, glomerular filtration rate,body weight index and eyeground were also studied. The results showed that 56 patients had obvious myocardial ischemia (group A),49 patients had slight myocardial ischemia (group B)and 395 patients were free from myocardial ischemia (group C). With positive 59MTc-MIBI ECT myocardiography, 15 among 16 patients in group A and 6 among 12 patients in group B and none among 5 in group C showed coronary artery narrowing in coronary radiography. The average course of DM,serum total cholesterol,fasting serum glucose and insulin, glucosylated hemoglobin.daily urine protein and the incidence of proliferative retinopathy of group A were higher than those of group B or C(P

We have conducted a tireless practice and exploration in order to establish a solid,long-term and appropriate social practice basement for medical students,which is the platform for them carrying on social practice activities.Practice has proved that early preparation for basement construction is the basis,support from local government is the key,leaders' attention 、abundant fund and multi-sectional coordination are the guarantee,and that diverse forms as well as effective social practice activities is the fundamental way to promote basement construction.

0.05).Spearman analysis revealed correlation between postoperative3 tibial plateau varus correction angle and functional recovery of knee joint(r=0.812,P

Objective To develop a set of hospital material management information system with the mature technique of barcode so as to realize the whole flow management of material.Methods By analyzing the main problems in present hospital material management,we put forward ways and procedures of material management,and gave an overall introduction to the composition of the system from three aspects: warehouse management on material and drugs,the second level storehouse management,such as material management in department,inspect reagent consumptive material management,no stock for high-cost medical consumables management,etc and the cost accounting and collecting system.The key technologies and implementation methods adopted in the designing process of this system were also introduced.Results The achievement of whole flow tracking management from material purchase to material consumption not only ensures a real whole flow management of materials,but effectively reduces the consumption of hospital materials.Conclusion With the mature and advanced technique of barcode and wireless network,the management of material can be better achieved.

Objective To observe the morphologic changes of of vascular buds in vertebral cartilage endplate in age-specific rabbits and also to investigate the correlation between the changes of vascular buds and interverbral disc degeneration. Methods There were 15 New Zealand white rabbits in our study,which include three groups, 2-week-old rabbits, 1-year-old rabbits and 3-year-old rabbits, and each groups had five rabbits. The X-ray radiograph, histology and scanning electron microscope were used to observe the changes of vertebral cartilage endplate. According to Miyamoto standard, the interverbral disc was graded 1-5, and scored 1-5 respectively. Results The changes of micro-vascular structure of vertebral cartilage endplate were observed during aging. Under the scanning electron microscope, the vascular structure degenerated gradually, and disappeared in the end. The blood vessels in the central region of the vertebral cartilage endplate reduced more obviously than those in periphery region. The severe degeneration was found in vertebral endplate, compared with intervertebral disc. The changes of vascular buds in rabbits vertebral cartilage endplate had positive correlation with the vertebral endplate calcification and the interbertebral disc degeneration. Conclusion Changes of vascular buds in vertebral endplate may accelerate intervertebral disc degeneration.

Objective To investigate the combined detection and clinical significance of autoantibodies in patients with autoimmune hepatitis (AIH).Methods Collected 1 593 cases of patients with hepatic dysfunction,33 cases were diagnosed as AIH.Serum anti-smooth muscle antibody (ASMA),soluble liver antigen/liver pancreas (SLA/LP) antibody,liver kidney microsomal-1 (LKM-1) antibody,hepatic cell solute antigen type-1 (LC-1) antibody,anti-mitochondrial antibody (AMA),antinuclear envelope glycoprotein (gp) 210 antibody,anti sp100 antibody,antinuclear antibody(ANA),anti extractable nuclear antigen antibody spectrum (ENA) and anti neutrophil cytoplasmic antibody (ANCA) were measured in patients.The clinical manifestations were recorded.Results In 33 patients with AIH,the positive rate of ANA was 81.8％(27/33).For the diagnosis of AIH,the sensitivity/specificity rate of ASMA were 57.6％(19/33)/97.6％(161/165).The sensitivity/specificity rate of LKM-1 antibody were 12.1％(4/33) /91.5％(151/165).The sensitivity/specificity rate of SLA/LP antibody were 6.1％(2/33)/99.4％(164/165).The sensitivity/specificity rate of anti LC-1 antibody were 9.1％ (3/33)/99.4％ (164/165).There were no antisp100 antibody and anti-gp210 antibody in AIH.Conclusion The diagnostic rate of AIH is improved by combined detection of autoantibodies.

Nonalcoholic fatty liver disease(NAFLD)is the most common cause for elevated liver enzymes in the developed nations.The treatment should be focused on the most important risk factors,obesity and insulin resistance.As a consequence of elucidating the pathogenesis of NAFLD,the number of potential therapeutic options increased,including weight reduction,antioxidants,insulinsensitizer,lipid lowering drugs and other liver protective drugs.The drug therapy for NAFLD was reviewed in this paper.

Objective To determine in vitro susceptibility of itroconazole,voriconazole,caspofungi,and amphotericin B against 82 clinical strains of filamentous fungi.Methods Etest method was used to test the in vitro susceptibilities of itroconazole,voriconazole,caspofungi,and amphoteriin B against aspergillus fumigatus,A.flavus,A.niger,A.terreus,A.nidulans,et al.Results The MIC range of 4 antifungal agents were 0.03~2.00 mg/L and 0.01~32.00 mg/L against A.fumigatus and A.flavus,respectively.But amphotericin B had higher MIC90 value which was 16mg/L against A.flavus than A.terreus(MIC90 3.00 mg/L),A.fumigatus(MIC90 0.75 mg/L),and A.niger(MIC90 0.25 mg/L).Conclusion Itroconazole,voriconazole,caspofungi,and amphotericin B have different susceptibility patterns against various types of filamentous fungi.It's necessary to identify fungi to level of species and perform antifungal susceptibility test in serious patients.

[Objective]To determine the effect of Oxfenmino hydrochloric acid on delayed allergic reaction in mouse. [ Method ] 120 ICR mice weighing 18~22g, half female and half male, were randomly and averagely divided into 6 groups according to weight:control group and model group (treated with distilled water at a dosage of 10ml/kg), three Oxfenmino hydrochloric acid groups (treated with Oxfenmino hydrochloric acid at a dosage of 10.0mg/kg, 5.0mg/kg and 2.5mg/kg respectively) and positive drug group (treated with CsA at a dosage of 15mg/kg); they were orally administered one time every day. After a continuous week of administration, all the groups were smeared evenly with 1%DNFB solution on the abdomen for allergy except the control group. Five days after allergy, 1%DNFB solution was smeared to right ear of all mice to stimulate the allergic reaction except that the control group was smeared with non-allergenic substance. 24 hours after attack, the auricle swelling, spleen index and thymus index in right mouse were determined. [ Result] Different dosages of Oxfenmino hydrochloric acid benefited to reduce auricle swelling, spleen index and thymus index in mouse with allergic reaction induced by DNFB at different degree. [ Conclusion] Oxfenmino hydrochloric acid can inhibit the delayed allergic reaction in mouse induced by DNFB and depress the ability of specific cell-mediated immunity.