At present,the relationship between hospitals and patients is becoming increasingly tense,which makes feasible approaches of benignization of the relationship worthy of probing into.The sample survey shows that a doctor or a nurse who is able to win patients'trust should treat patients equally,respect patients'personality,enhance mutual understanding,regard patients as their relatives,possess noble professional morality and foster a nice individual image.

The reasons what the phenomenon of Hongbao exist are intricate and complex.The existence of the phenomenon of Hongbao blasphemes against the medical care justice,accelerate the relationship between hospital and patients tension.It will be a fact that the Chinese society unable to radical change in established period.We need to reduce the appearance of the phenomenon of Hongbao as many as possible,and prepare for eliminating the unreasonable and unjust social phenomenon finally.

This paper defines the implication of mutual love between doctors and patients,analyzes the tendency and imperfection in present physician-patient relationship,and points out that the mutual love between doctors and patients is the guarantee for a harmonious physician-patient relationship.It is not only a theoretical ideal,but also a practice of medical service.It holds to propose fair and initiative mutual love between doctors and patients in China,realize general love for all individuals by government,and strengthen the sense of love for others among all ranks of populations.

Drug Discovery ; Humans ; Multiple Myeloma ; drug therapy

The characteristics and clinical application of the arrival of qi in suspended moxibustion was discussed in this paper. Through literature research and clinical practice, three aspects, including characteristics of arrival of qi in suspended moxibustion, the clinical basis regarding arrival of qi in suspended moxibustion improving therapeutic effects and how to acquire arrival of qi in suspended moxibustion, were discussed to clarify the essential role of arrival of qi in suspended moxibustion as well as its importance to the development of moxibustion medicine. The suspended moxibustion at acupoints could produce arrival of qi similar to acupuncture, which was characterized as non-local or non-superficial heat sensation such as penetrating heat, expanding heat, transmitting heat, even non-hot sensation such as aching, numbing, distending, painful, heavy, cold sensation in the applied region. It is heat-sensitive sensation phenomenon that can improve therapeutic effect in suspended moxibustion.
Acupuncture Points ; Humans ; Moxibustion ; methods ; Qi ; Thermosensing

Objective:To systematically evaluate the efficacy and safety of demethylation drugs intreatment of myelodysplastic syndrome (MDS), and to provide reliable basis and guidance for clinical application of these drugs.Methods:The randomized controlled trials (RCT) of demethylation drugs for treatment of MDS published in the PubMed, Web of Science, Embase, Cochrane Library, Chinese Journal Full-text Database (CNKI), Chinese Biomedical Literature Database (CBM) and VIP database from January 2000 to December 2019 were searched by computer. RevMan 5.3 software was used for Meta-analysis of the efficacy and safety.Results:Seven RCT studies involving 1 172 patients were obtained. Meta-analysis showed that the complete remission rate ( OR = 6.26, 95% CI 1.74-22.49, P = 0.005), partial remission rate ( OR = 4.65, 95% CI 1.51-14.29, P = 0.007), overall response rate ( OR = 14.14, 95% CI 7.27-27.51, P < 0.01), hematology improves ( OR = 3.47, 95% CI 1.44-8.32, P = 0.005) in the demethylation drug treatment group were better than those in the best supportive treatment group. Meanwhile, the overall survival of patients in azacytidine group was improved ( HR = 0.62, 95% CI 0.50-0.77, P < 0.01). In terms of adverse reactions, demethylation drugs increased the incidence of neutropenic fever ( OR = 4.19, 95% CI 2.26-7.76, P < 0.01). However, there was no significant difference in the incidence of neutropenia, thrombocytopenia, anemia, infection, nausea, liver damage and fatigue between the two groups (all P > 0.05). Conclusions:The effect of demethylation drugs in treatment of MDS is obvious, the remission rate can be improved, and azacytidine can prolong the patients' survival, but demethylation drugs increase the incidence of neutropenia fever. In the clinical application of demethylation drugs, it is necessary to further carefully evaluate their clinical safety.

Objective:To observe the effect of emotional resilience training on compassion fatigue and psychological resilience of intensive care unit nurses.Methods:A total of 70 intensive care unit nurses were randomly divided into experiment group and control group, each of 35 cases. Control group nurses were given routine psychological guidance intervention, in addition, the experiment group was carried out 8 weeks of emotional resilience training. The effect of intervention was assessed by Chinese version of the compassion fatigue scale and Connor-Davidson resilience scale before and after intervention.Results:After intervention, the average scores of compassion satisfaction, secondary traumatic stress and total compassion fatigue scores were (26.46±4.99)pionts, (17.80±4.05)pionts and (69.14±5.70)pionts, significantly lower than in the control group (28.86±4.14)pionts, (20.11±4.38)pionts and (75.51±10.32)pionts, the difference was statistically significant ( t value was 2.190, 2.296, 3.197, P<0.05). After intervention, the average scores of tenacity, power, optimism and total resilience scores were (34.23±6.06)pionts, (25.77±5.01)pionts, (14.31±3.22)pionts and (74.31±9.55)pionts, significantly higher than in the control group (30.86±6.23)pionts, (23.31±3.29)pionts, (12.11±2.04)pionts and (66.29±7.28)pionts, the difference was statistically significant ( t value was 2.295-3.956, P<0.05). Conclusion:Emotional resilience training can effectively reduce the compassion fatigue and improve psychological resilience of intensive care unit nurses.

Objective To explore nursing scheduling mode in ICU. Methods Grouping was carried out on the basis of nursing decentralized management and the two-way selection between group heads and group members. The research target was the 60 nurses in ICU. Degrees of the nurses' job satisfaction and changes of nursing quality before and after grouping were compared and analyzed. Results The general degree of the nurses' satisfaction towards scheduling was (3.75±0.70) points before grouping while (4.30±0.50) points six months after grouping. The difference had the statistical significance (t=6.5645, P < 0.01);the scores of nursing quality check on classification management, ward management, nursing security, emergency management and hospital infection management were (91.97±1.47), (93.07± 1.66), (93.43 ± 1.50), (94.03 ± 1.10), (94.07 ± 1.39) points respectively before grouping and (95.08 ± 1.63), (95.77±1.55), (96.07±1.41), (97.37±1.56) and (97.07±1.48) points respectively six months after grouping. The differences had the statistical significance (t=6.5192-10.9934, P<0.01). Conclusions The two-way selection among nurses and decentralized management grouping can improve the degree of nurses′job satisfaction and nursing quality.

Objective To investigate the regulation of Sertoli cells on differentiation balance of allogeneic regulatory T cell (Treg)and T helper cell(Th17).Methods Sertoli cells ,bone marrow‐derived dendritic cells(DC) and T lymphocytes were iso‐latedandculturedinvitro.SertolicellsandDCcellswereco‐culturedwithallogeneicTcells,respectively.MorphologyofSertoli cells were verified under the light microscope and electron microscope. The expression of major histocompatibility complex (MHC)‐Ⅱ and B7‐H1 in Sertoli cells was detected by Western blot.Concentration of cytokines[transforming growth factor (TGF)‐β1 and IL‐17A etc. ] in supernatant was determined by enzyme linked immunosorbent assay(ELISA). The frequency of Treg cells differentiated from na?ve T cells was estimated by flow cytometry.Results Sertoli cells were successfully isolated and cultured in vitro.Western blot results showed the expression of MHC‐Ⅱ and B7‐H1 on Sertoli cells surface was increased significantly ,when Sertoli cells were co‐cultured with allogeneic na?ve CD4+ T cells(CD4+ CD62 L+CD25)in vitro.ELISA re‐sults showed the TGF‐β1 concentration in culture supernatant was significantly increased [from (174.89 ± 23.51) pg/mL to (823.10 ± 59.07) pg/mL ,P<0.05] .Flow cytometry results showed Na?ve T cells(CD4+CD62 L+CD25-)were induced to dif‐ferentiate into CD25+ Foxp3+ T cells(from <1.0% up to 27.6% )by co‐cultured with Sertoli cells.And incubation with Sertoli/Treg supernatant(STS)significantly reduced the concentration of IL‐17A in the mixed culture supernatant of DC cells /Na?ve CD4+ T cell[from (361.58 ± 80.27) pg/mL to (137.54 ± 52.19) pg/mL ,P<0.05]. The percentage of IL‐17A+ T cells subset was also significantly decreased(27.2% to 17.9% ,P<0.05).Conclusion The anti‐inflammatory cytokines and immune sup‐
pressive cytokines derived from Sertoli cells can induce allogeneic na?ve T cells to differentiate into CD25+ Foxp3+ Treg cells in vitro.Sertoli cells can regulate the differentiation balance of allogeneic Treg/Th17 to induce the immune tolerance.

Objective:To explore the temporal expression of retinal-choroidal transforming growth factor-?2(TGF-?2) in form-deprived myopia(FDM) chick eyes and study the effect of an inhibitor(disulfiram,DSF) of retinoid acid(RA) synthesis on refractive development and the expression of TGF-?2.Methods:Ninety new hatched white leghorn chicks were divided randomly and equally into 3 groups:unilateral occluded with frosted goggles(Group A);unilateral intravitreal injection of 4 mmol of the non-specific aldehydedehydrogenase inhibitor disulfiram with further treatment with goggles(Group B);unilateral intravitreal injections of 4 mmol of disulfiram without further treatment with goggles(Group C).Refraction and axial length were measured on 1,7 and 14 days after treatment.Expression levels of TGF-?2 and TGF-?2 mRNA in the retinal-choroid layer were analyzed by immunohistochemistry and real-time RT-PCR.Results:In Group A,the form-deprived eyes made by goggles developed myopia(P0.05) with TGF-?2 mRNA level growing on day 7 and decreased on day 14 in group B and decreased on day 1,increased on days 7 and 14 in Group C(P