From April 2011 to October 2013,68 patients scheduled for complex hepatobiliary and pancreatic surgery underwent full-thickness suturing of abdominal incision with subcutaneous negative pressure drainage.There was no such complications as wound dehiscence or sinus formation.Except for 2 cases of wound infection,primary healing was achieved.Two infected cases were followed up for 1 year and there was incisional hernia.The full-thickness suturing of abdominal incision plus subcutaneous negative pressure drainage could prevent postoperative wound infection and promote wound healing.And this simple and practical approach is worthy of wider clinical application.

As the newest anti-vascular endothelial grown factor (VEGF) drug,alfibercept binds to all forms of VEGF-A,VEGF-B, and PIGF.So far, intravitreal injection of alfibercept has already been used to treat certain opthalmological diseases, such as neovascular age-related macular degeneration, polypoidal choroidal vasculopathy, central retinal vascular occlusion, diabetic macular edema, corneal neovascular,and retinopathy of prematurity.In this article,we contrasted alfibercept to the other anti-VEGF drugs, conducted a review of the recent research progress of alfibercept in opthalmological diseases and introduced the questions which still need to be solved and the probably research direction of alfibercept in the future.

Antiinflammatio No. 6 (AI6) is an effective anti-infective drug composed of four traditional Chinese medicines, namely, Lonicera japonica Thunb, Taraxacum mongolican I-Iand-Mazz, Isatis tinctoria L. and Houttuynia cordata Thunb. It was demonstrated in our experiments that the drug was able to enhance the oxidative burst of rat peritoneal macrophages as shown by increased production of H_2O_2 and exaggerated reduction of nitroblue tetrazolium (NBT). It seems likely that by these means AI6 could promote the bactericidal function of macrophagcs. NBT rcduction of macrophages was examined both by spectrophotometric quantification and electromicroscopic observation.

The paper summarized the current situation of diagnosis and treatment of pancreatic endocrine tumors (PETs)in China.In recent sixty years, we understand PETs more deeply, and have all kinds of imaging technique to localize the tumors.It makes more cases having been diagnosed.Operation is the most important and the first choice of treatment.The concept of minimal-invasion runs through the surgical procedure.Multi-model strategy is used in therapy for malignant PETs with liver metastasis.Basic research is focused in mechanism and early diagnosis and it helps the clinical practice.Specialization and co-operation are emphasized in the development of PETs diagnosis and treatment.

The theory of'preventing possible disease'in Traditional Chinese Medicine(TCM) is an important content of present theoretical and applied researches in TCM.After learning Daoxue and Chinese medicine,the author believes that ancient people give more attention to vitality than physique.Most of the diseases are caused by the injury of vitality,so the key to 'preventing possible disease'is not only conservation of the physique,but also conservation of the vitality.It is emphasized that the heart can communicate with natural pneuma,and the body can follow the qi transformation of nature when the human body is in the natural state.When one concentrates his spirit internally and keeps a sound mind,the genuine qi will come in the wake of it,and illness can be avoided.Researches on the theory of'preventing possible disease'must not ignore the apprehension and exploration of vitality.

Adult ; Humans ; Orthodontics, Corrective ; methods ; Periodontium

The effect of trichosanthin on mast cell degranulation and histamine release were observed with both Alcian blue staining method and fluorescent histamine determination method. It was showed that, ① in vitro trichosanthin showed no direct effect on the mast cell degranulation and histamine release even in the presence of fresh serum; ② in vivo administration on of trichosanthin in mice could cause significant mast cell degranulation and histamine release in inflammatory situ, as shown by the decreased number of Alcian blue stained nondegranulated mast cell in the peritoneal cavities; ③ intra peritoneal injection of trichosanthin in Wistar rats could significantly increase histamine level in the whole blood, while inducing prominent exudation of protein into the peritoneal cavities; ④ the supernatant of peritoneal exudate lavaged 12 hours after trichosanthin injection could cause mast cell degranulation. These results implicate that, although it showed no direct effect on mast cells, trichosanthin could cause mast cell to degranulate and release histamine via in vivo activation of some soluble mast cell degranulating factors. It was discovered in further study that the depletion of complement by cobra venom factor injection revealed no effect on the production of mast cell degranulation factor, suggesting that, in normal animals, the trichosanthininduced complement activation had no significant influence on the mast cell degranulation and histamine release.

Objective To investigate the acoustic f eatures of voice in patients with abnormal lung function, evaluate the effect o f lung dysfunction on acoustics of voice,and observe the relationship between re spiration and phonation. Methods The voice signals of sustained vowel /a/ were mea sured by a micro-computer with Dr.speech science for windows software in 50 pati ents with abnormal lung function and 50 healthy adults. The acoustic parameters( F0,jitter,shimmer,intensity,NNE) were collected and analysed in lowest pitch,no rmal pitch and highest pitch.All patients were divided into two groups according to sex. Results In patients with abnormal lung function ,the pa rameters (shimmer, jitter, NNE,)were significantly increased or others(F0,inten sity) were significantly decreased in lowest pitch. Intensity decreased si gnificantly in highest pitch . There was a positive relationship between the de grees of lung dysfunction and the parameters of acoustics. Conclusion Abnormal lung function affected significantly on acoustics of voice in three different pitches; The changes of the parameters were related to the degrees of lung function.The results showed that respiratory activities play an important role in phonation.

With the increasing incidence and high malignancy, pancreatic cancer is still expected to be treated by radical resection. However, because of the unique anatomical and biological features, such as rapid progression, early metas-tasis and direct invasion to the vessels, the resection rate of pan-creatic cancer is still at a lower level. The standard procedures of diagnosis and treatment, including early detection, preopera-tive resectability assessment, and judgement of the resection area based on the tumor staging, benefit the patients and significantly improve the prognosis.

0.05). However, there were quite improvements of survival rate and survival quality for cervical adenocacinoma. Their 5-year survival rates were 91% and 33% (P