Objective To investigate the effects of iri doid on the spermatogenesis in mice of type-2 diabetes induced by nicotinamide and streptozotocin. Methods Fifty-six male C57BL mice were randomly divided into seven groups (n=8 for each group):control group, diabetic group, diabetic and glibenclamide (0.25 mg/kg) group, diabetic and iridoid (20 and 40 mg/kg) group, and iridoid (20 and 40 mg/kg) group. Diabetic model was induced by intraperitoneal injection of streptozotocin (65 mg/kg) and nicotinamide (120 mg/kg). Glibenclamide and iridoid were orally fed for 28 days. Twenty-four hours after the last treatment, blood samples, testis and the epididymis were collected for detecting blood hormones, testicular biopsy, and the evaluation of sperm parameters. Results The body weights of diabetic mice were recovered from the reduction after treatment with 40 mg/kg of iridoid and glibenclamide(P<0.05). The sperm count and viability were significantly decreased in diabetic group compared with those of control group (P<0.05). The sperm count was significantly increased in diabetic and glibenclamide group than that of diabetic group (P<0.05). The serum levels of lutein hormone (LH), follicle stimulating hormone (FSH) and testosterone (T) were significantly decreased in diabetic group compared with those of control group (P<0.05). The serum levels of LH, FSH and T were increased after treatment with 40 mg/kg of iridoid and glibenclamide (P<0.05). Conclusion These results suggest that iridoid can reduce the level of oxidative damage in
diabetic mice, and effectively improve the fertility of mice.

Child ; China ; epidemiology ; Diagnosis, Differential ; Early Diagnosis ; Hematopoietic Stem Cell Transplantation ; methods ; Humans ; Immunoglobulins, Intravenous ; administration & dosage ; pharmacology ; Immunologic Deficiency Syndromes ; diagnosis ; epidemiology ; prevention & control ; therapy ; Immunologic Factors ; administration & dosage ; pharmacology ; Infant, Newborn ; Neonatal Screening

Objective To investigate the relationship of serum uric acid level with carotid atherosclerosis and intracranial stenosis in patients with cerebral ischemic stroke.Methods 186 patients checked by Color Doppler Flow Imaging (CDFI) and Transcranial Doppler (TCD) were enrolled.According to the degree of carotid intima-media thickness (IMT), patients were divided into normal group, and intima thicken group, the plaque shaping group and the vascular stenosis group.According to the degree of intracranial stenosis, patients were divided into stenosis group and nonstenosis group.The serum levels of uric acid (UA), triglycerides (TG), total cholesterol (TC), highdensity lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C) were detected.The relative factors for carotid atherosclerosis and intracranial stenosis were analyzed by multiple logistic regression analysis.Results Compared with normal group and intima thicken group, the percentage of patients with hypertension, coronary heart disease and serum TC level were increased in plaque shaping group and vascular stenosis group (P＜0.05 for all).With the increase of carotid IMT, serum UA level was also gradually increased (F=11.386, P =0.000).Logistic regression analysis showed that serum UA level was the independent risk factor for carotid atherosclerosis (OR=3.486, P=0.013).Among 186 patients, 43 cases (23.1％) had intracranial vascular stenosis.The UA level was higher in stenosis group than in non stenosis group (t=9.372, P=0.013).Logistic regression analysis showed that serum UA level were the independent risk factors for intracranial arterial stenosis (OR =1.914, P=0.022).Conclusions The occurrence of carotid atherosclerosis and intracranial stenosis are closely related with hyperuricemia in patients with cerebral ischemic stroke, which indicates serum uric acid level may reflect the degree of carotid artery atherosclerosis.

Recently ,metabolic surgery has received much concern for its notable and everlasting effectiveness on glucose control ,weight loss and other metabolic disorders and concomitant diseases. Previous clinical practice and guidelines mostly focused on surgical indications ,especially BM I cut‐off point. In recent years ,BMI cut‐off point in guidelines has shown a downtrend and BMI cut‐off value has tended to become obscure ,which harvested from that clinical staff have realized the importance of comprehensive control for long‐term multiple metabolism and risk factors and overall benefit of the patients through increased clinical evidences and no longer limited to the improvement of obesity and diabetes itself.

Objective To study the the effectiveness of Entecavir on serum transforming growth factor-β1 (TGF-β1) in patients with decompensated cirrhosis .Methods Eighty patients with decompensated cirrhosis were randomly divided into two groups ,the control group(n=40 cases) and the observation group (n=40 cases).The pa-tients in the control group were treated through the conventional treatmeat ,while the patients in the observation group were treated through the conventional treatment plus entecavir .They were treated for 24 weeks.Liver function,HBV DNA and serum TGF-β1 were detected.Results ALT,Tbil and ALB were improved after treatment in both groups (t=6.724,13.306,3.064,4.172,2.924,3.172,all P<0.05).They were more significantly improved in the obser-vation group than that in the control group (t=2.469,2.160,3.064,all P<0.05).HBV-DNA negative rate in the observation group was higher these in the control group (χ2 =4.82,P<0.05).Serum TGF-β1 in both groups were decreased after treatment(t=6.842,8.062,all P<0.01).There was a significant difference between two groups (t=3.178,P<0.05).Conclusion Entecavir can decrease serum TGF-β1 in patients with decompensated cirrhosis .

OBJECTIVE:To discuss the development of the core competitive power of domestic vitamin C manufacturing enterprises.METHODS:To analyse the characteristic of vitamin C industry in China and the competitive situation in the new market enviroment after China entry into WTO and to study the value chain of Chinese enterprises.RESULTS&CONCLU?SION:In order to develop the new core competitive power,it is important to breed the core of value chain that is based on in?novation.

Cleft lip and palate (CLP) is one of common congenital malformations. The evaluation of upper airway morphology using two-dimensional (2D) and three-dimensional (3D) imaging data for CLP patients has important clinical significance. Studies have adopted various measurement methods,in which different anatomical landmarks and reference planes are used in 2D cephalometric measurement. Shooting positioning for cone beam computed tomography (CBCT), measurement software, reference plane, landmark selection, and measurement method in 3D studiesare also different. Currently,comparison is unable to be performed across different studies due to various measurement methods and measurement standards. This article reviews studies on upper airway morphology measurement in CLP patients.

With the improvement of social living standard and the continuous promotion of patients' requirements,the integrated nursing work has already been a complicated and creative job,and brings nursing staff a huge psychological stress.A good mental character is one of the key factors that builds up and adjusts the harmonious relationship between patients and nurses,furthermore,is also a necessity for nurses to accomplish integrated nursing work.Therefore,it is hospital governors' first consideration to help nurses relive mental pressures and improve their adapting capacity.

0.05),but all the outcome measures at 1 month in the treatment group were significantly improved as compared with control group(P0.05).The mean light sensitivity in the treatment group was better than in control group(P

OBJECTIVE:To provide references for the management and use of the donated drugs for earthquake resistance and disaster relief.METHODS:The problems appeared in the management and use of the donated drugs after the earthquake occurred on May 12,2008 in Sichuan province of China were summarized analytically and the corresponding suggestions were put forward.RESULTS & CONCLUSION:Some problems such as the turnover of the drugs,the expiration date,drug dispensing and allocation etc appeared in the management and use of the donated drugs,which should be standardized by setting related laws and regulations to make more greater use of the limited drug resource in the disaster relieving.