Guillain-Barre Syndrome ; Humans

The study aims to identify related substances in orlistat pharmaceutical substance from different production technologies. Advanced technologies including UPLC-QTOF-MS and UPLC-QTrap-MS were used and the structures or molecules of 10 kinds of related substances in orlistat were identified. The experimental data were valuable to the quality control and development of orlistat.
Anti-Obesity Agents ; analysis ; chemistry ; Chromatography, High Pressure Liquid ; Drug Contamination ; Lactones ; analysis ; chemistry ; Quality Control ; Spectrometry, Mass, Electrospray Ionization ; Tandem Mass Spectrometry

Constriction, Pathologic ; diagnosis ; pathology ; therapy ; Humans ; Palate, Soft ; pathology ; Sleep Apnea, Obstructive ; diagnosis ; pathology ; therapy ; Tongue ; pathology ; Uvula ; pathology

Acupuncture Therapy ; methods ; Adolescent ; Adult ; Electroacupuncture ; Female ; Humans ; Male ; Medicine, Chinese Traditional ; Middle Aged ; Obesity ; therapy

Objective To observe the clinical outcomes of modified posteromedial and posterolateral approaches for the treatment of posterior tibial plateau fractures.Methods Between January 2006 and October 2011,25 patients with posterior tibial plateau fracture were identified.They were 17 men and 8 women,aged from 22 to 76 years (average,46.4 years).According to the AO/OTA classification,there were 4 cases of type 41-B1,6 cases of type 41-B2 and 15 cases of type 41-B3.According to Luo's three-column classification,they were all posterior column fractures.Ten patients with posterolateral tibial plateau fracture were treated by the modified posterolateral approach and the other 15 patients with posteromedial tibial plateau fracture by the modified posteromedial approach.The posterior fractures were fixated with a buttress plate.The knee function was evaluated at the last follow-up by the The Hospital for Special Surgery (HSS) Score.Results All the 25 cases were followed up for a mean time of 13.2 months (from 10 to 24 months).By the radiological Rasmussen criteria for fracture reduction,the mean score immediately after surgery was 16.5 points (from 13 to 18 points),with 20 excellent cases,4 good cases and one fair case.All patients were pain-free with full range of motion.Radiologically,bone union was achieved in all cases after a mean time of 13.9 weeks (from 12 to 18 weeks).No surgery-related complications were found.The mean HSS score was 91 points(range,74 to 97 points) and the good to excellent rate was 100％ (17 excellent and 8 good cases) at the last follow-up.The average range of knee motion ranged from 0° to 125°.Conclusion In the treatment of posterior tibial plateau fractures,because the modified posteromedial and posterolateral approaches can result in excellent fracture reduction under direct visualization and allow for posterior buttress plating,soft tissues can be well preserved and good functional results can be expected.

Objective To analyse CT findings and CT diagnostic value of the giant cystic lesions in abdomen.Methods CT findings of the giant cystic lesions in abdomen were retrospectively analyzed in 28 pathologically proven cases.Results In 28 cases,there were 4 cases of ovarian cystic, 1 ovarian serous cystadenoma, 1 ovarian mucinous cystadenoma, 3 giant hydronephrosis, 2 cyst of kidney, 2 cyst of ureter,3 pancreatic pseudocyst, 3 splenic cyst, 2 congenital common bile duct cyst, 1 hepatic cyst, 2 cystic lymphangioma, 1 urachal cyst, 1retroperitoneal cystic liposarcoma, 1 unmature cystic teratoma and 1 cystic metastatic carcinoma. Up to 92.9% of the giant cystic lesions inabdomen was benign. Each disease was of its own features on CT scans and certainly location.Conclusion CT is very effective imagingmodality in localization and qualitative diagnosis of the giant cystic lesions in abdomen.

Background Many surgical techniques are used to improve the postoperative visual acuity for rhegmatogenous retinal detachment(RRD)during recent decade,and scleral buckling surgery is one of these operations.Whether the visual function after operation can be rescued is an important issue. Objective The aim of this study was to analyze the risk factors of influencing the postoperative vision following scleral buckling surgery for primary macula-off RRD. Methods The clinical and follow-up data from consecutive series of 116 eyes of 116 patients received scleral buckling surgery for primary maeula-off RRD were retrospectively reviewed.The relationship of multiple factors,including age,preoperative best corrected visual acuity(BCVA),duration of disease,refractive error,location of retinal hole,number of retinal hole,area and height of retina detachment,management of subretinal fluid and intravitreal gas injection,with visual acuity were analyzed respectively by χ2 test.The correlations among statistically significant factors with postoperative vision were analyzed by multivariate Logistic regression analysis.Written informed consent was obtained from any patient before surgery. Results The postoperative vision outcome was found with significantly difference among different preoperative vision groups(P=0.002)and different course (P=0.009).There were significant differences between the groups with different preoperative BCVA(P=0.002)and duration of disease(P=0.009).Multivariate Logistic regression analysis showed that the preoperative BCVA was the only variable affecting postoperative visual result(r=0.400,P=0.009).Considerable linear correlation wag seen between preoperative vision and postoperative vision(r= 0.400,P=0.000).The probability with postoperative vision of t>0.4 in the eyes with preoperative≥0.05 was 3 folds more than that of preoperative<0.05(OR=2.992).The better visual outcome after scleral buckling surgery was seen in the eyes with the course≤7 days. Conclusion Preoperative BCVA and duration of disease are the key factors associated with the postoperative BCVA.Scleral buckling surgery should be performed within the first week for primary macula-off RRD.

[Objective] To discuss effective way for Prominent Lumbar Intervertebral Disc.[Method] Apply shinbone tube seal and dimensional traction on 118 cases of the said patients.[Result] After following up for 3~18 months,62 cases were very good,occupying 52%;43 good,36%;10 bad,8%;no effect 3,2%,the effective rate 88%.[Conclusion] It is safe and one of good therapies presently to treat Prominent Lumbar Intervertebral Disc with shinbone tube seal and dimensional traction.

Objective To study the improving effect of testicular tissue graft on impaired learning and memory in endocrine recession mice,and to explore the possible mechanisms.Method Forty Kunming male mice were randomly divided into four groups by random number table:sham operation group,castration group,androgen (30 mg/kg) control group and testicular tissue graft group.The bilateral testes of mice were cut off to establish castrated mouse model.After modeling,the back subcutaneous muscle layers of castrated mice were implanted on the allogeneic testicular tissue blocks in graft group.Androgen group mice were intragastrically administrated with androgen for three months,and other two groups of mice were given an equal volume of normal saline At the end of treatment,the levels of serum testosterone in each group of mice were measured by ELISA.Learning and memory abilities of the mice were assessed by Morris water maze behavioral test.Morphological changes in the hippocampal CA1 region were observed through hematoxylin-eosin staining (HE).The expression levels of AR and apoptosis-related proteins (Bcl-2,Bax,caspase-3 and caspase-9) in the brain were detected by Westem blotting.Result As compared with castration group,the levels of serum testosterone in graft group were increased significantly (P＜0.01),learning and memory abilities were greatly strengthened (P ＜ 0.01),the morphological structures in hippocampal CA1 neurons were improved,and the expression levels of Bax,caspase-3 and caspase-9 were significantly reduced (P＜0.01),while the expression levels of AR and Bcl-2 had obvious enhancements (P ＜0.01).Conelusion Testicular tissue graft can improve learning and memory ability probably by secreting endogenous testosterone which will bind with androgen receptor in the brain,then regulating the expression of neuronal apoptosis related genes,increasing Bcl-2 protein level and reducing the expression of Bax,caspase-3 and caspase-9 protein,and finally inhibiting neuronal apoptosis.

Non-arteritic anterior ischemic optic neuropathy (NAION) is one of the most common acute optic neuropathy in adult characterized with impaired visual acuity and visual fields.The pathogenesis of NAION mostly result from the interactions between the systemic risk factors (such as diabetes mellitus,night hypotension, hereditary) and the local ocular risk factors (such as small optic disc and vitreo-papillary traction).A fully promoted diagnosis and treatment of NAION are based on the higher levels of clinical cvidence, as well as the comprehensive assessment of relationship between the systemic and ocular risk factors in the pathogenesis of NAION.Secondary optic neuropathy of NAION and the early diagnosis with effective treatment of the fellow eye would be highly emphasized.