0.05).(2)After suspension for 2 weeks,the total effective rate was 89.65% in the treatment group and 46.43% in the control group,the difference being significant between the two groups(P

Anaplastic thyroid cancer (ATC) is the most aggressive thyroid tumor, with lower morbidity and higher mortality rates. Radical surgery could improve local control and survival rates. Conformal radiotherapy is superior to conventional radiotherapy, which could improve the patients’ quality of life. There are a few chemotherapeutic drugs against ATC, and the outcome of chemotherapy alone is modest. Concurrent chemoradiotherapy can prolong the survival. Targeted therapy brings new hope for refractory patients. Many cancer centers are exploring surgery, radiotherapy, chemotherapy, targeted therapy and other biological treatment of comprehensive application, in order to enhance the curative effect. This article reviewed the foregoing treatments for ATC.

Enterovirus 71 (EV71) is one of the most important causes of hand-foot-mouth disease and herpangina.EV71,due to its neurotropic nature,can also cause severe complications of the central nervous system than other types of enterovirus.EV71 infection also causes devastating syndromes such as acute pulmonary edema,pulmonary hemorrhage and cardiopulmonary failure.In this review,clinical manifestations and the pathogenesis of central nervous system dysfunction after EV71 infection were described.

Objective To observe the clinical efficacy of ganciclovir in treatment of children with viral encephalitis.Methods 80 children with viral encephalitis were randomly divided into observation group and control group.All patients received the comprehensive treatment including anti-spasm,dehydration,control of body temperature,decreased intracranial pressure and drugs of improving brain metabolism.40 children in the observation group received intravenous ganciclovir.40 patients in the control group received intravenous ribavirin.The clinical effect of the two groups was compared.Results The total effective rate of observation group was 92.5％,that of the control group was 70.0％,the difference was statistically significant (x2 =6.721,P ＜ 0.05).In the observation group,the main clinical symptoms including fever,headache,vomiting,convulsions and the disappearance time of unconsciousness were significantly shorter than the control group(t =5.270,9.730,5.749,5.903,5.421,all P ＜ 0.05).The incidence rate of adverse reactions in the observation group was 7.5％,which was lower than 17.5％ in the control group,but the difference was not statistically significant (all P ＞ 0.05).Conclusion Ganciclovir in the treatment of children with viral encephalitis can improve clinical symptoms in a short time,and adverse reactions are mild,which can be used as the ideal choice for treatment of children with viral encephalitis.

The peripherally inserted central catheter occlusion is not rare in adults.Its occurence is related with the catheter's tip position,catheter type and the skills of medical staff.Personnel training is particularly important in the prevention of occlusion.Urokinase and heparin can be used for thrombolysis.

BACKGROUND:Studies have shown that the physical development potential is often associates with certain combinations of hand print features.
OBJECTIVE:To analyze the body shape and structure characteristics of national women’s handbal team athletes.
METHODS:Fifty national women’s handbal team athletes were col ected from Shanghai, Beijing, Tianjin and Anhui provinces and PLA. The body shapes of the athletes were measured by the Research Institute of National Sports Council, and the hand prints were col ected. The common factors of body shape and structure characteristics were analyzed with factor analysis method, including height, weight, forearm length, wrist circumference, hand length, hand width and index finger length and large-handedness index.
RESULTS AND CONCLUSION:The body shape and structure characteristics of national women’s handbal team athletes could be divided into four types:long trunk lean type indicator, hand skeleton and muscle fiber development level index, flexible quality indicators as wel as the alertness and mental level indicators. The long trunk lean type indicator was the main factor to affect body shape and structure characteristics of national women’s handbal team athletes.

[Objective] To observe Yishi Oral Liquid effect on treating middle and old aged asthenopia. [Method] Choose 125 cases of middle and old aged asthenopia, and randomly divide them into observation group 65 cases treated wutg Yishi Oral Liquid, and control group 60 cases with Mingmu Rehmannia Pil;meanwhile both groups reduced the time with the eye and made massage on the acupoints around the eyes. [Result] With 2~4 weeks of treatment, in the observation group, 23 cases were cured, 25 had marked effect, 13 effective, 11 had no effect, the total effective rate was 93.85%;for the control one, they were respectively 14,19,16,11 and 81.67%. The comparison showed the observation group was better than control one. [Conclusion] Yishi Oral Liquid treating middle and old aged asthenopia has good clinical effect, can obviously relieve the symptoms of blurred vision, phengophobia, lacrimation and aningerestling eyes, helpful to recovering eyesight.

Objective To investigate clinical characteristics of children infected with Klebsiella pneumonia (KP) in community and nosocomial ,and analysis briefly about their resistance .Methods 79 cases of children with pneumonia identified as KP infection by the method of sputum bacterial culture were collected and divided into nosocomial infection group (11 cases) and community in-fection group(68 cases) from January 2009 to December 2012 .The clinical information were recorded ,sputum bacterial susceptibili-ty and extended-spectrum β-lactamase enzyme were tested .Results 10 cases and 12 cases of extended-spectrumβ-lactamase enzyme strains were detected from nosocomial infection group and community infection group ,respectively .The children infected KP had a high degree of resistance to cefazolin ,ampicillin/sulbactam ,head penicillin ,ceftriaxone ,aztreonam ,cefepime and ceftazidime ,while sensitive to ciprofloxacin ,cefotetan and piperacillin/tazobactam in the nosocomial infection group .12 cases in community infection group produce highly resistant to penicillin-type drugs ,but were not obvious resistance to other types of antibiotics .Conclusion Multi-drug resistance problems are serious in the pneumonia children who infected KP and the extended-spectrum β-lactamase en-zyme is positive .Infected children should be treated differently in the selection of antibiotics in the treatment of infection in commu-nity and nosocomial .

Designed experiment is a new experimental mode characterized by the student-centered and toacher-oriented teaching principle.To conform with the general trend of experimental teaching reform in medica university,Biochemistry Department of Third Military Medical University attemptod to adopt this teaching mode.It was indicated that designed experiment is favorable for the enhancement of comprehensive diathesis and will be an effective way to cultivate high-quality medical intellectuals.

ObjectiveTo study the value of serum soluble intercellular adhesion molecule-1 (sICAM-1),B-type natriuretic peptide (BNP) and C-reactive protein (CRP) levels detection on assessment of illness in patients with congestive heart failure.MethodsSixty-three patients with congestive heart failure were involved in this study.The levels of serum sICAM-1,BNP and CRP were compared in patients with different NYHA cardiac function classification before and after treatment.ResultsThe levels of serum sICAM-1,BNP and CRP in NYHA cardiac function classification ≥ Ⅲ grade patients were significantly higher than those in NYHA cardiac function classification ＜ Ⅲ grade patients[ (392.6 ± 73.3) μ g/L vs.(212.6 ± 83.4) μ g/L,( 1992.5 ±1173.7) ng/L vs.(512.6 ± 283.2) ng/L,(49.3 ± 33.5 ) mg/L vs.(6.1 ± 3.6) mg/L] (P ＜ 0.01 ).The levels of serum sICAM-1,BNP and CRP after treatment were significantly decreased compared with those before treatment [ ( 168.9 ± 52.5) μ g/L vs.(362.8 ± 123.1 ) μ g/L,(68.6 ± 38.4) ng/L vs.(1470.9± 1460.1) ng/L,(3.6±2.8) mg/L vs.(34.1 ±29.8) mg/L] (P ＜ 0.01).Conclusion Serum sICAM-1,BNP and CRP levels are positively related with illness,and serum sICAM-1,BNP and CRP levels may be judged as an index assessing treatment effect and prognosis.