The incidence of gastroesophageal junction cancers is rapidly increasing, the Year' s upwards rate being more than 5％ ～ 10％. Siewert in 1987 proposed a definition for adenocarcinoma of the esophagogastric junction (AEG), as a adenocarcinoma within 5 cm of the gastroesophageal junction (GEJ), and divided AEG in to three types. The majority of patients with AEG in Asian countries have type Ⅱ and Ⅲ cancers, and no obvious differences have been reported in 5-year survival rates between patients with different types of AEG. In contrast, in western countries, the distribution of each type of AEG is nearly equal,patients with AEG type Ⅰ cancer have the best prognosis, whereas the overall survival of patients with type Ⅲ cancer is the worst. Now people presume that the AEG is a special type of carcinoma which is not same as carcinoma of esophagus and stomach. The surgical routes and operative methods and the extent of lymph node dissection of AEG are still not completely clear, and AEG lacks also a independent TNM system for itself. We will summarize the actuality of diagnosis and therapy of AEG.

The results of morphological observations and measurements of 200 Chinese male adult mandibular alveolar arches are as follows: 1.The average measuremants of the mandibular arch depth and arch breadth are 4.62 cm and 5.03 cm respectively. 2.The shape of the arch can be either square or pointed depending upon whether the value of the arch/chord index is greater or smaller than 95. 3.There are four curved line equations for left-external,left internal,right- external and right-internal half arches computed from the plotted geometrical configuration.All errors are less than 0.001 cm,while the coefficients of co-relation are greater than 0.999.This proves that the result of this research work is success- ful. 4.The total area of the alveolar region of Chinese adult male mandibles is 12.15 cm~2 in average.

Objective:To investigate the expression and significance of an inhibitor gene of apoptosis,Clusterin,in prostate cancer,and its relationship with the expression of bcl-2,FasL.Methods:The expression of Clusterin,bcl-2 and FasL in sample of 10 normal prostate,15 BPH and 49 prostate cancer were examined by immunohistochemical stain.Results:The rate of positive or weak positive for normal prostate,BPH and prostate cancer was 10%(1/10),66.6%(10/15)and 91.8%(45/49) respectively.The expression level of Clusterin in prostate cancer was much higher than in normal prostate(P

OBJECTIVE:To study the pharmacokinetic characteristics of esomeprazole capsules versus esomeprazole tablets in healthy volunteers and to evaluate their bioequivalence.METHODS:A single oral dose of 40 mg esomeprazole capsules or esomeprazole tablets was given to 24 healthy male volunteers who were randomly assigned to two groups in an open randomized crossover test.The plasma concentration was determined by HPLC.The pharmacokinetic parameters of esomeprazole were analyzed by DAS 2.0 program.The bioequivalence of the two preparations was evaluated.RESULTS:The pharmacokinetic parameters of esomeprazole capsules and esomeprazole tablets were as follows:Cmax were(884.71?265.97)ng?mL-1 and(919.53?218.44)ng?mL-1;tmax were(1.45?0.39)h and(1.65?0.45)h;t1/2 were(2.30?0.51)h and(2.23?0.47)h;AUC0～12 were(3 897.50?1 033.58)ng?h?mL-1 and(4 059.57?1 715.07)ng?h?mL-1;AUC0～∞ were(4 222.70?1 066.73)ng?h?mL-1 and(4 320.22?1 426.73)ng?h?mL-1.The relative bioavailability of esomeprazole capsules was(96.01 ?10.5)%.CONCLUSION:Esomeprazole capsules and esomeprazole tablets are bioequivalent.

Objective To determine short-term therapeutic efficacy and side effect of postoperative 3-dimensional conformal radiotherapy for malignant glioma.Methods From January 2003 to January 2005, 62 patients with malignant glioma postoperation were randomized into two groups,32 entered in 3DCRT group and 30 entered in ordinary radiotherapy group.The dose of radiotherapy was 60 Gy/30 f, 6 weeks. Results The overall response rate in the 3DCRT group was 87.5 %(28/32),in the ordinary radiotherapy group was 73.3 %(22/30).There were no statistical significance(P=0.158).The survival rates at 1-,2-year were 90.6 % (29/32),81.3 %(26/32)in the 3DCRT group and 80 %(24/30),56.7 %(17/30)in the ordinary radiotherapy group. The difference was significant(P

Objective To evaluate the effectiveness and to access the feasibility in reinforcing the quality of clinical teaching by introducing the conception of clinical pathway (CP) to the course of urology. Methods Sixty clinical medical students were randomly divided into two groups called CP group and tra-ditional group. The CP group's interns were provided with CP text which was considered as the core of the whole learning process. The interns would find the problems and solve problems according to the content of CP text. At last the teachers would summarize. Traditional group's teachers would introduce the disease systematically according to the teaching syllabus and screening suitable cases for interns to inquiry and have a physical examination. The two groups were evaluated systematically after four weeks of different teaching methods which concluded physical examination and written examination. An independent sample t test was used for the result of the operation and the written test and chi square test was used for satisfaction survey. Results The clinical pathway group's after-department examination score [(88.1±4.5) vs. (73.0± 7.3)], clinical skill scores [(88.1±4.5) vs. (73.0±7.3)] and the undergraduate interns' understanding of their comprehensive ability of disease (P=0.028) such as their team cooperation ability, their communication ability (P=0.0.15), (P=0.007) analysis and their ability to treat disease, as well as improving the evaluation ability and their comprehensive evaluation of teachers' teaching completion degree and teaching skills, , are all better than the traditional teaching group. Conclusion CP teaching applied in clinical teaching of urol-ogy is conducive to improving the quality of clinical teaching, and can enhance clinical interns' comprehen-sive ability and improve teaching satisfaction.

Objective To observe the efffects of angiotensin Ⅱ receptor antagonist (ARB) valsartan in decreasing blood pressure and protecting kidney to the patients suffering from mild-or-moderate hypertension companied with earlier type 2 diabetic nephropathy. Methods The patients suffering from mild-to-moderate hypertension and earlier type 2 diabetic nephropathy were divided into two groups. One of the groups were treated by valsartan, and the other were treated by betaloc and aldadinc. The period of the treatment and doses of the medicines were adjusted depending on the blood pressure 4 weeks later. The therapeutic effects of the two medicines were analyzed 6 months later. Results There was no difference in the effects of decreasing blood pressure and side-effects between the two groups. There are marked discrepancy between the two groups in the post-trearment 24h urinary albumin excretion rate (UAER) and the variation of 24h UAER (all P<0.05). There was no significant difference in others parameters (all P0.05). Conclusion Valsartan could prevent early proteinuria of type 2 diabetic nephropathy from developping and protect the function of kidney.

Objective:To explore the therapeutical effect of Tetramethylpyrazine on chronic allograft nephropathy of rat, reveal the relationship with CAN, then discovering mechanism of action that delaying the proceeding of CAN of rat, which provide a new way of therapy to extend survival time of transplanting kidney. Methods: We used Fisher rats as donors and Lewis rats as recipients to establish the model of CAN. 75 rats with transplanting kidney were divided into 3 groups: Ciclosporin group, TMP associating with Ciclosporin group and black group; every group for 25 rats. Renal cell apop totic index was examined by means of terminal deoxynucleotidyl transferase2mediated d-UTP nick end labeling (TUNEL). The expressions of Bcl-2 and Bax in kidney was immunohistochemically evaluated and. The kidney histology were observed by light microscope. Results:The rats of black group were died in two weeks. Ciclosporin group, appearance the histopathological changes of CAN since 4th week, it is thus evident that typical histopathological changes of CAN at 12th week. TMP associating with Ciclosporin group was later. There was significant difference(P

OBJECTIVE To analyze the characteristics of Klebsiella pneumoniae and the result of sputum culture and its clinical significance.METHODS The sputum was cultured to detect the susceptibility to antibiotics,as well as to accumulate the data of clinical cases.RESULTS Total of 82 strains were obtained.Imipenem sensitivity was 100.00%,followed by levofloxacin and ciprofloxacin,with sensitive rates(95.10% and 92.7%).Thirty-two ESBLs producing strains were accounted for 39.02%.CONCLUSIONS Part of the K.pneumoniae strains are extended spectrum beta-lactamase-producing Enterobacteriaceae and insensitive to the commonly used antibiotics.It is suggested the antibiotics be used according to drug sensitivity.

This article describes the definition of the term TDM (i. e. therapeutic drug monitoring), presents the past history, present status and future prospects of individualized dosing regimen, and emphasizes the role of population pharmacokinetics and one point feedback Bayesian method played in the design of dosing regimen.