Livin is a new member of the inhibitors of apoptosis protein(IAP) gene family. It is highly expressed in most human tumors, involved in inhibiting cell apoptosis, and closely related with tumor occurrence, development and prognosis. So Livin could be a new target for tumorous early diagnosis and cancer therapy. This paper summarizes the Livin gene molecular structure, tissue expression, biological function,and its application in cancer treatment.

AIM: To understand the effects of benazepril in treating the diastolic function of the left ventricular in patients with hypertention and coronary heart diseases(CHD).　METHODS: Forty-five hypertension patients with the left ventricular diastolic dysfunction(LVDD) received benazepril 10-20 mg, po,qd, for 5 mo. On the basis of receiving nitrates 36 CHD patients with LVDD added to receive benazepril 5 mg, po, qd, for 5 mo. Before and after the therapy, the utmost speed of the peak value at the left ventricular early diastole stage (E peak), the utmost speed of the peak value at the left ventricular late diastolic stage (A peak), the E/A ratio and peak filling rate (PFR) were determined by color Doppler echocardiography. 　RESULTS: After the therapy, the E peak, the E/A ratio and PFR were up higher than before the therapy, meanwhile the A peak dropped lower, there were significant difference respectively (P<0.01). 　CONCLUSION: The LVDD can be improved distinctly if the patients with hypertension and CHD take benazepril for 5 mo or so.

Peripheral nerve block technique is one of the basic skills necessary to residents and it is also one of the difficult points in the resident standardized training in the department of anesthesiology. In order to maximize the learning effect of the anesthesia professional residents in the case of limited number of cases, we need to constantly enrich the teaching technologies and teaching methods. Human 3D anatomy is used for theory teaching to maintain comprehension of nerve anatomy; Ultrasound-guided nerve block technique and ultrasound simulation training are used for nerve block practice to improve nerve block skills;Problem-based learning teaching method is introduced in nerve block cases to increase the residents' ability of clinical cases management.

Objective: To analyze the present situation of the management of large-scale instruments in a medical school and give some reasonable suggestions. Methods: Through the research on the use of 85 large-scale instruments in our university, we tried to find out the methods of improving the utilization ratio of large-scale instruments. Results:There are many reasons of the poor management and low utilization rate of large-scale instruments in medical schools. Conclusion: Taking some measures could effectively improve the utilization rate of large-scale instruments in medical schools, such as simplifying the working procedure, solving the operating and repair expenses, strictly controlling argumentation, drawing up scientific evaluation and incentive measures and so on.

Objective To isolate and identify the components from the stem barks of Morus yunnanensis.Methods The compounds were isolated and purified by silic gel column,Sephadex LH-20,and RP-18 chromatography.Their chemical structures were elucidated on the basis of physicochemical properties and spectral data.Results Eleven compounds were isolated and identified as:mulberroside C(1),oxyresveratrol(2),2',4',7-trihydroxy-(2S)-flavone(3),norartocarpetin(4),moracin P(5),betulinic acid(6),sitosteryl 3?-glucoside 6'-O-palmitate(7),lupeol(8),betulinic acid(9),?-daucosterol(10),and ?-sitosterol(11).Conclusion All the compounds are isolated from the plant for the first time,and compound 9 shows cytotoxic activities.

underweight group. There was a negative correlation between body mass index and HDL.C concentration (r = - 0.088, p

Objective To evaluate the effect of superficial temporal fascia flap for the reconstruction of temporal depression. Methods According to the degree of temporal depression, we applied folded superficial temporal fascia to reconstruct the temporal depression, combined with forehead and orbital subperiosteal facelift. Results Postoperative follow-up for 1~2 years showed that the method used in subperiosteal facelift combined with temporal depression, maintained a satisfactory long-term full contour. And it improved the facial contour.Conclusions Application of superficial temporal fascia flap in reconstructing the temporal depression combined with facelift for one-stage is a good method. It can get the purposes of tightening the skin and improving the facial contour together. Good results are achieved.

0.05).84.58%(28/33)of the expanding bone destruction were resulted from benign and 84.62%(33/39) of the aggressive bone destruction were resulted from malignant.The form of bone destruction of maxillary sinus in the benign and the malignant was different(? 2=34.61,?

Objective To study telomere dynamics in bone marrow from patients with leukemia and myelodysplastic syndromes (MDS) by flow cytometry and FISH (FLOW FISH) Methods By FLOW FISH , we detected telomere lengths of leukocytes in bone marrow from 43 leukemia patients and 48 healthy donors The mean fluorescence intensity of cells (Q FISH) was detected by flow cytometer Results Compared with the age matched normal range (0 066?0 015), 38 of 43 patients had shortened telomere length (0 047?0 019), and the remaining patients (3 MDS and 2 chromic phase CML) had normal telomere lengths (0 069?0 007 vs 0 060?0 008) Although no significant difference in telomere lengths could be demonstrated in 8 leukemia patients at diagnosis and follow up, a trend toward telomere shortening was observed in CLL patients with 0 052 vs 0 048 in which telomere tended to shorten as the disease went on In contrast, longer telomeres were found in AML patients after induction chemotherapy (0 056) compared with those found in diagnostic specimens (0 043) In the healthy donors, the telomere length turned to be shorter with increase of age ( r =0 67), whereas in leukemia and MDS patients, the telomere length had no correlation with age ( r =0 14) Conclusion The telomere lengths from most patients with leukemia and MDS were shorter than that of healthy donors The telomere dynamics is associated with prognosis and therapy of disease

OBJECTIVE To investigate the bacterial distribution and the extent of drug resistance in lower respiratory tract disease among aged people.METHODS From Jan 2006 to Dec 2006 we collected 304 sputum samples of the old patients who were diagnosed lower respiratory tract infection,bacterial distribution and antibiotic resistance of 178 strains of the pathogens were analyzed retrospectively.RESULTS The most common four kinds of Gram-negative bacilli were Pseudomonas aeruginosa,Klebsiella pneumoniae,Escherichia coli and Acinetobacter baumannii.For above bacteria,the ratio of the resistance to ampicillin,cefazolin and compound sulfamethoxazole was over 40%.The isolating rate of ESBLs-producing E.coli and K.pneumoniae was 29.8%.CONCLUSIONS Monitoring the common bacteria and ESBLs bacteria precisely can provide therapy,guide to early cure and control lower respiratory tract infection of aged patients effectively.