1.Periodontitis exacerbates pulmonary hypertension by promoting IFNγ+T cell infiltration in mice
Meng XIAOQIAN ; Du LINJUAN ; Xu SHUO ; Zhou LUJUN ; Chen BOYAN ; Li YULIN ; Chen CHUMAO ; Ye HUILIN ; Zhang JUN ; Tian GUOCAI ; Bai XUEBING ; Dong TING ; Lin WENZHEN ; Sun MENGJUN ; Zhou KECONG ; Liu YAN ; Zhang WUCHANG ; Duan SHENGZHONG
International Journal of Oral Science 2024;16(2):359-369
Uncovering the risk factors of pulmonary hypertension and its mechanisms is crucial for the prevention and treatment of the disease.In the current study,we showed that experimental periodontitis,which was established by ligation of molars followed by orally smearing subgingival plaques from patients with periodontitis,exacerbated hypoxia-induced pulmonary hypertension in mice.Mechanistically,periodontitis dysregulated the pulmonary microbiota by promoting ectopic colonization and enrichment of oral bacteria in the lungs,contributing to pulmonary infiltration of interferon gamma positive(IFNγ+)T cells and aggravating the progression of pulmonary hypertension.In addition,we identified Prevotella zoogleoformans as the critical periodontitis-associated bacterium driving the exacerbation of pulmonary hypertension by periodontitis,and the exacerbation was potently ameliorated by both cervical lymph node excision and IFNγ neutralizing antibodies.Our study suggests a proof of concept that the combined prevention and treatment of periodontitis and pulmonary hypertension are necessary.
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