Cheilitis ; Humans ; Pemphigus/diagnosis*

Cheilitis is a general term for various types of inflammatory diseases that occur on the lips. The etiology differs and the clinical manifestations and pathological features overlap, leading to difficulties in clinical diagnosis. Reasonable classification is conducive to the diagnosis of cheilitis. However, its classification is difficult because of its cha-racteristics. At present, scholars have proposed two different classification schemes, but a unified classification standard has not yet been established. We classified cheilitis based on its etiology, clinical manifestations, pathological characteristics, and relationship with systemic and special diseases on the basis of special medical reports and by combining clinical practice experience and summarizing previous cheilitis diagnosis and treatment literature. In accordance with this classification method, we proposed suggestions for the clinical diagnosis of cheilitis to provide a reference for the clinical diagnosis and treatment of complex cheilitis.
Cheilitis/diagnosis* ; Diagnosis, Differential ; Humans ; Lip

Candidiasis is a common fungal infection that usually affects the oral cavity. It is occasionally difficult to diagnose candidiasis because of its various clinical manifestations. Moreover, chronic inflammation of the lips can obscure clarification of its disease entity in patients with chronic cheilitis. Here we aimed to investigate patients with refractory chronic cheilitis who were initially diagnosed with candidiasis. We screened patients with lip lesions that were clinically suspected to have candidiasis. Our two 65-year-old patients with refractory chronic cheilitis were initially diagnosed with candidal infection. Punch biopsies were performed of the lesions and a diagnosis of actinic cheilitis was made in both patients. Since we did not note prominent improvement after conservative treatment and cryotherapy, we applied 0.015% ingenol mebutate gel for further treatment and then observed significant improvement.
Actins* ; Aged ; Biopsy ; Candidiasis ; Cheilitis* ; Cryotherapy ; Diagnosis ; Humans ; Inflammation ; Lip ; Mouth

Angiolymphoid hyperplasia with eosinophilia (ALHE) is a benign uncommon disorder of uncertain etiology. It presents as solitary or multiple intradermal or subcutaneous red to brown papules or nodules usually on the head and neck. Overlying epidermis is usually intact. Oral involvement such as lip or oral mucosa is quite rare, and presents as a nodule, macule, plaque, tumor, and ulcer. We report a 68-year-old female patient presenting erythematous ulcerated and crusted patch on the lower lip. Histopathological diagnosis was ALHE and overlying actinic cheilitis.
Actins ; Aged ; Angiolymphoid Hyperplasia with Eosinophilia* ; Cheilitis ; Diagnosis ; Epidermis ; Female ; Head ; Humans ; Lip* ; Mouth Mucosa ; Neck ; Ulcer*

BACKGROUND: Three age-depedent clinical phases(infantile, childhood and adult phase) of atopic dermatitis(AD) were recognized. We think that for t he diagnosis of AD there seems to be some differences in minor clinical features of diagnosic significance according to each phase, yet only a few studies about them. OBJECTIVES: The purprrse of the present study was to evalute the diagnostic significance of total 39 minor clinical features of AD in Korean adolescenc and adult popluation, all but only skin were proposed by our previous study for Korean children. METHODS: The frequeney of 39 minor clinical features wistudied in 82 patients with typical AD compared to that in 109 control subjects. The age all studied individuals ranged from 13 to 42 years. Furthermore, some characteristic micro features of AD in them were compared with those from our previous study for Korean children. RESULTS: Twenty-seven minor features including xerosis, peifolhcular accentuation, frontal lichenification, anterior neck folds, eyelid eczema, Dennie-Mogan folds, auricular fissure/eczema, pityriasis alba, ventiral wrist eczema, infragluteal eczcm, sandpaper-like skin lesions on elbow/knee/lateral malleblus, white dermographism, scalaling, Hertoghes sign, orbital darkening, cheilitis, facial erythema/pallor, hyperlinear paln, ichthyosiform skin lesions, nipple eczema, nummular eczema, pompholyx, itchy hyperker totic lesions of dorsal hands, knuckle dermatitis of hands, hangnail, non-specific hand/foot dermatitis, chronic dermatophytosis were shown to be of much diagnostic signiic, nce(P<0.001). CONCLUSION: We think tiat 13 minor features such as Hert piges sign, cheilitis, facial erythe- mapallor, hyperlinear ichthyosiform skin lesions, ripile eczema, nummular eczema, pompholyx, itchy hyperkpratotic lesions of dorsal hands, kzukle dermatitis of hands, hangnail, non-specific hand/foot dermatitis, chronic dermato h tosis are specific for Korean adolescence and adult population with AD. Taken together, to propose that these 13 minor features be added to a gardeline for the large scale field sirvy on the incidence and prevalence of AD in the Korea adolescence and adult population.
Adolescent* ; Adult* ; Cheilitis ; Child ; Dermatitis ; Dermatitis, Atopic* ; Diagnosis ; Eczema ; Eczema, Dyshidrotic ; Eyelids ; Hand ; Humans ; Incidence ; Korea* ; Neck ; Nipples ; Orbit ; Pityriasis ; Prevalence ; Skin ; Tinea ; Wrist

BACKGROUND: The incidence of atopic of atopic dermatitis (AD) varies widely by different ages and it has been well-founded that the epidemiology of AD has been studied on admission of the first grade schoolchildren. AD is a common skin disease of childhood and tends to increase significantly during recent decades, but informations regarding the exact prevalence of AD, based on the large-scale general population study, are unavailable in korea. OBJECTIVE: The purpose of this study is to elucidate the exact prevalence of AD and to evaluate the diagnostic significance of some well-known minor clinical features associated with AD in the first grade school children in one of Kouean cities, Puchon, kyunggi-do. METHODS: Four thousands and eighteen first grde school children (boys ; 2072, girls ; 1946) participated inthis study. Two dermatologists determined the presence of skin lesions by through skin examination. Diagnosis of AD was made only when typical flexural and/or extensor and/or infraauricular fissure/eczema exist. The frequency as well as their diagnostic significance of ten minor features of AD (xerosis, ichthyosiform skin lesion, hyperlinear palm,)keratosis pilaris, non-specific hand/foot dermatitis, cheilitis, nipple eczema, perifollicular accentuation, pityriasis alba, Dennie-Morgan infraorbital fold) thought suitable items for field survey by authors, were also evaluated. RESULTS: The total prevalence of AD in the first grade school children of Puchon city was 3. 78%. The prevalence in boys was 3.37% and that in girls was 4.2 Associated minor features in individuals diagnosed as having AD were, in order of frequency, pityriasis alba (59.8%), perifollicular accentuation (57.8%), , keratosis pilaris (56.5%), hyperlinear palms (55.2%), xerosis (43.3%), Dennie-Morgan infraorbital fold (26.3%), etc. All but the ichthyosiform skin lesions and nipple eczema were significantly more frequent in individuals diagnosed as having AD (P<0.01). CONCLUSION: A relatively low prevalence shown in this study might be due to rather strict diagnostic criteria. Some helpful and diagnostically significant minor clinical features of AD, suitable for field survy, is suggested. Further studies are needed for accurate estimation of the prevalence of AD in korea including different regional and age population.
Cheilitis ; Child ; Dermatitis ; Dermatitis, Atopic* ; Diagnosis ; Eczema ; Epidemiology ; Female ; Gyeonggi-do ; Humans ; Incidence ; Keratosis ; Korea ; Nipples ; Pityriasis ; Prevalence* ; Skin ; Skin Diseases

BACKGROUND: There is concem about the rising incidence of skin cancer. However, few articles have reported the change in the clinical and epidemiological aspects of skin cancer. OBJECTIVE: We performed this study in order to clarifiy the recent changes in cutaneous premalignant and malignant lesions. METHODS: A statistical analysis was made using 101 cases of cutaneous premalignant lesions and 205 cases of ma]ignant tumors out of a total number of 20,175 new outpatients that visited the Department of Dermatology at the Seoul National University Hospital during a 6 year period(1990-1995). RESULTS: The frequency of premalignant lesions was 0.50% and that of malignant tumors was 1.02%. The frequency showed an increasing tendency compared to previous reports. In the premalignant lesion cases, actinic keratosis was most common and represented a figure of 82.2%. Among the malignant tumors, basal cell carcinoma was most frequent at 24.4%. Age, sex and anatomical site distribution of basal cell carcinoma, malignant melanoma was no different. The mean age of squamous cell carcinoma was greater than in previous reports and main preceding lesions were actinic keratosis and cheilitis. The frequency of lymphoma was markedly increased but the reason for this remains to be determined. CONCLUSION: Our findings showed the continous increasing incidence of skin cancers and emphasize the need for public eduacation, early diagnosis and proper treatment.
Carcinoma, Basal Cell ; Carcinoma, Squamous Cell ; Cheilitis ; Dermatology ; Early Diagnosis ; Humans ; Incidence ; Keratosis, Actinic ; Lymphoma ; Melanoma ; Outpatients ; Seoul ; Skin Neoplasms ; Statistics as Topic*

BACKGROUND: Lip skin diseases are common findings in dermatology. However, most dermatologists are not familiar with the clinical features of lip skin diseases due to the special characteristics of the lip. OBJECTIVE: This study aimed to evaluate the clinical and histopathological features of lip skin diseases. METHODS: We retrospectively reviewed 259 patients who underwent biopsy for labial diseases at the Department of Dermatology from January 2002 to December 2011. We compared the clinical and histopathological diagnoses and analyzed the rate of concurrence and labial tumor distribution. In addition, demographic and clinical features, including age, sex, location, and disease duration, were investigated. RESULTS: The mean age of the patients was 56.8 years and the male-to-female ratio was 1:0.77. Lip skin diseases accounted for 4.1% of all new patients during the study period, with the lower lip being the most commonly affected site (88.4%). The most common disease was actinic cheilitis (35.1%), followed by chronic cheilitis (11.6%), mucocele (10.0%), and squamous cell carcinoma (9.7%). The most common type of tumor was actinic cheilitis (54.8%), followed by mucocele (15.7%), squamous cell carcinoma (15.1%), hemangioma (4.2%), pyogenic granuloma (4.2%), keratoacanthoma (1.8%), and basal cell carcinoma (1.2%). Before the patients came to the university hospital, they received medical treatment at various clinics and departments, including dermatology clinics (55.3%), internal medicine (26.2%) and urology departments (10.7%), and general practitioners (9.7%). CONCLUSION: This study provides novel and useful data on the incidence and characteristics of lip skin diseases. Compared to previous studies, the frequency of lip tumors was relatively high and variable in this study. Based on these results, we advise physicians to, if in doubt, initially diagnose and treat for actinic cheilitis and labial tumors (especially squamous cell carcinoma) caused by long term exposure to the sun.
Actins ; Biopsy ; Carcinoma, Basal Cell ; Carcinoma, Squamous Cell ; Cheilitis ; Dermatology ; Diagnosis ; General Practitioners ; Granuloma, Pyogenic ; Hemangioma ; Humans ; Incidence ; Internal Medicine ; Keratoacanthoma ; Lip* ; Mucocele ; Retrospective Studies ; Skin Diseases* ; Solar System ; Urology

BACKGROUND: Labial diseases are common in dermatology. However, few studies have reported the clinical and histopathologic features of labial diseases in Korea. OBJECTIVE: This study was designed to investigate the clinical and histopathologic features of labial diseases. METHODS: We retrospectively reviewed 242 patients who received biopsy for labial diseases between January 2005 and May 2010. We compared clinical and histopahtologic diagnoses and analyzed the rate of concurrence. In addition, clinical features, including age, sex, and location, associated cutaneous lesions of 11 major labial diseases, which were confirmed by histopathology, were investigated. RESULTS: The mean age of the patients was 52.2 years. The male to female ratio was 1:1.5. Lower lip was the most commonly involved (77.4%). The most frequent final diagnosis was venous lake, followed by nonspecific inflammation, labial melanotic macule, plasma cell cheilitis, postinflammatory hyperpigmentation, squamous cell carcinoma, lichen planus, mucocele, Fordyce's disease, pyogenic granuloma, and actinic cheilits. Venous lake showed the highest match rate (86.3%), whereas cheilitis simplex exhibited the lowest match rate (0.0%). We also analyzed the clinical features of 11 major labial diseases. The majority of labial diseases occurred in old patients, except for mucocele, Fordyce's disease, or labial melanotic macule. Most diseases occurred predominantly in females, whereas squamous cell carcinoma, plasma cell cheilits, and Fordyce's disease were male-dominant. The most commonly involved location was the lower lip, except for Fordyce's disease. Associated skin lesions, such as ulcers, hyperkeratosis, or whitish patches, were observed in squamous cell carcinoma, plasma cell cheilitis, actinic cheilitis, and lichen planus. CONCLUSION: Compared to previous studies, the actual frequency of actinic cheilitis and squamous cell carcinoma was relatively lower while that of plasma cell cheilitis was relatively higher. We suggest that actinic cheilitis and squamous cell carcinoma are less frequently confirmed than previously expected and that plasma cell cheilitis should be included in the differential diagnosis of labial lesions, especially when they are located on the lower lip and occur in old patients.
Actins ; Biopsy ; Carcinoma, Squamous Cell ; Cheilitis ; Dermatology ; Diagnosis, Differential ; Female ; Granuloma, Pyogenic ; Humans ; Hyperpigmentation ; Inflammation ; Korea ; Lakes ; Lichen Planus ; Lichens ; Lip ; Male ; Methylmethacrylates ; Mucocele ; Plasma Cells ; Polystyrenes ; Retrospective Studies ; Skin ; Ulcer