In order to study the exposure level of silica dust and the effects of silica dust on ventilatory function, respirable dust samples were collected by personal air samplers using NIOSH method 0500 from the selected foundry operations, and ventilatory function tests were performed on 209 male foundry workers and 239 male control subjects. Ventilatory indices such as forced vital capacity (FVC) , one-second forced expiratory volume (FEV1), ratio of FEV1 to FVC(FEV1 %), maximal mid-expiratory flow(MMF), peak expiratory flow rate (PEFR) and maximal expiratory flow at 25, 50 and 75 % of expired FVC (FEF25, FEF50, FEF75 were obtained by analyzing forced expiratory spirogram and maximal expiratory flow-volume curve which were simultaneously measured by Vitalography in standing position. The results were as follows : 1. The average quartz concentrations of respirable dust were the highest in melting operation (0.079 mg/m3) and followed by molding operation (0.051 mg/m3), finishing operation (0.041 mg/m3) and coremaking operation (0.023 mg/m3) in the descending order. 2. No significant differences for mean values of all ventilatory indices expressed as percent of predicted value were demonstrated between smokers and nonsmokers In foundry workers and control subjects. 3. Mean values of all ventilatory indices except FVC of foundry workers were significantly lower than those of control subjects. 4. Mean values of FEV1 %, MMF, FEF25, FEF50 and FEF75 expressed as percent of predicted value tended to decrease with increasing cumulative dust exposure. 5. In foundry workers, proportions of workers with low MMF, FEF50 and FEF75 were markedly higher than those with other indices, and were significantly increased with increasing cumulative dust exposure. 6. In foundry workers, 2 workers(1.0 %) were diagnosed as silicosis and the profusion of radiographic opacities were category 1/0 and q type. With the above considerations in mind, it suggested that increasing exposure of silica dust be associated with progressive deterioration in ventilatory function of an obstructive nature and that MMF, FEF50 and FEF75 be more sensitive indices in the detection of the early obstructive changes of air flow of workers exposed to silica dust.
Dust* ; Forced Expiratory Volume ; Freezing ; Fungi ; Humans ; Male ; National Institute for Occupational Safety and Health (U.S.) ; Peak Expiratory Flow Rate ; Quartz ; Silicon Dioxide* ; Silicosis ; Vital Capacity

Malignant transformation of mature cystic teratoma is a rare complication. Most com-mon malignant transformation of mature cystic teratoma is squamous cell carcinoma, which represents about 75 to 80% followed by adenocarcinoma in 6 to 7%. It is generally consi-dered that prognosis is extremely poor in case of adenocarcinoma associated with cystic te-ratoma. In this paper, we describe an adenocarcinoma arising from a mature cystic teratoma of left ovary in 47 year old woman. Left ovary was measured 18x15x7cm, 1,295gm in size. Uterus and right ovary were normal appearance. Left ovarian cyst was adhered to omentum and peritoneum. But neither rupture of cyst nor ascites were found at laparotomy. A brief review of concerned literatures was presented.
Adenocarcinoma* ; Ascites ; Carcinoma, Squamous Cell ; Female ; Humans ; Laparotomy ; Middle Aged ; Omentum ; Ovarian Cysts ; Ovary* ; Peritoneum ; Prognosis ; Rupture ; Teratoma* ; Uterus

Massive pulmonary embolism is a major cause of morbidity and death in hospital. Most episodes of acute pulmonary embolism occurred from multiple emboli. When pulmonary embolism is suspected, the definitive diagnosis is pulmonary arteriography, but high degree of certainty can also be achieved with ventilation-perfusion scanning. The therapeutic modalities available for patients with acute pulmonary embolism are prophylatic and definitive therapy. Prophylatic therapy including anticoagulant with heparin is used to prevent further emboli episodes that might be fatal. Definitive therapy for pulmonary embolism including thrombolytic agents and pulmonary embolectomy attempts to dissolve and remove the resolution of the pathophysiologic sequelae of pulmonary embolism. We experienced a case of acute massive pulmonary embolism which occupied the pulmonary arteries bilaterally. Patient with orthopedic surgery one month before developedd dyspnea and chest tightness. Eventhough continuing enough amount of anticoagulant therapy, rapid hemodynamic deterioration and severe hypoxia occurred progressively. Urgent pulmonary embolectomy was succeeded and he has been followed up at out patient department.
Angiography ; Anoxia ; Diagnosis ; Dyspnea ; Embolectomy ; Fibrinolytic Agents ; Hemodynamics ; Heparin ; Humans ; Orthopedics ; Pulmonary Artery* ; Pulmonary Embolism* ; Thorax

OBJECTIVE: Effects of life style modifications on lipid profiles have been well established. However, data is scarce in Korean patients. We tried to quantify the effect of life style modifications on lipid profiles in relatively large number of Korean hyperlipidemic patients. METHODS: This study enrolled 1037 consecutive hyperlipidemic patients (total cholesterol or triglyceride levels ≥200 mg/dL) from 2003 to 2013. They were consisted of patients with hypercholesterolemia (n=308), borderline hypercholesterolemia (n=302), mixed hyperlipidemia (n=107), borderline mixed hyperlipidemia (n=156), and hypertriglyceridemia (n=164). Blood lipid levels were measured before and after life style modification for 2-4 months. RESULTS: Life style modification showed a small but significant reduction of body weight in all groups. It reduced low density lipoprotein (LDL) cholesterol by 9.1% (p=0.000), 5.9% (p=0.000), and 4.8% (p=0.003) in patients with hypercholesterolemia, borderline hypercholesterolemia, and mixed hyperlipidemia, respectively. LDL cholesterol was elevated in hypertriglyceridemic patients by 35% (p=0.000). Triglyceride levels decreased in patients with hypertriglyceridemia by 22% (p=0.000) and increased in hypercholesterolemic patients. There were no different effects of life style modification between men and women. CONCLUSION: Life style modification made significant improvement in lipid profiles in Korean patients. The degree of improvement from this study may provide useful data for the management of Korean hyperlipidemic patients.
Body Weight ; Cholesterol ; Cholesterol, LDL ; Diet Therapy ; Female ; Humans ; Hypercholesterolemia ; Hyperlipidemias* ; Hypertriglyceridemia ; Life Style* ; Lipoproteins ; Male ; Triglycerides

PURPOSE: This study examined the effects of health status and health behaviors on depression in married female immigrants in South Korea. METHODS: Sampling 316 immigrant women from the Philippines, Vietnam, China, and other Asian countries, a cross-sectional research design was used with self-report questionnaires that assessed sociodemographic characteristics, health status, health behaviors, and depression. RESULTS: There were significant differences in stillbirth experience, induced abortion, morbidity, perceived health status, meal skipping, and physical activity between depressed and nondepressed immigrant women. After adjusting for sociodemographic variables, stillbirth experience, poorer perceived health status, more meal skipping, and less physical activity were associated with greater depressive symptoms. CONCLUSIONS: Both health status and health behaviors had significant impacts on depression, suggesting that development of nursing interventions and educational programs should be targeted towards improving maternal health, healthy lifestyle, and subjective health perception to promote married female immigrants' psychological well-being.
Adult ; Asian Continental Ancestry Group/ethnology ; Cross-Sectional Studies ; Depressive Disorder/*epidemiology ; Emigrants and Immigrants/statistics & numerical data ; Female ; *Health Behavior ; *Health Status ; Humans ; Logistic Models ; *Marriage ; Republic of Korea/epidemiology ; Risk Factors ; Rural Health ; Socioeconomic Factors ; Surveys and Questionnaires ; Urban Health ; Young Adult

The interruption of hepatic blood flow has been adopted as a method of bleeding control in hepatectomy and liver transplantation. But this occlusion of hepatic inflow may result in significant hepatic injury by various kinds of oxygen radicals produced as a result of hepatic ischemia and following reperfusion. Arterial ketone body ratio(AKBR) is adequatc and convenient parameter by which both acute and prolonged changes of the hepatic function can be estimated. Pharmacological modulation of hepatic injury during warm ischemia and early reperfusion has shown some benefical effects. The authors conducted an experiment to evaluate the inhibitory effect of glutathione and prostaglandin E on hepatic injury due to acute hepatic ischemia and reperfusion. Thirty rabbits were divided into three groups, such as control(n=10), GSH(n=10) and PGE(n=10) groups. Acute hepatic ischemia was induced through the application of portal triad cross-clamping for 30 minutes, and thereafter hepatic reperfusion was induced with the removal of cross-clamping. A single bolus of 200 mg glutathione was injected 10 min before clamp in GSH group, and 200 ng/kg/min of PGE continuously from 10 min before clamp to 30 min after declamp in PGE group. AKBR and hepatic histological findings hefore clamp, 30 min after clamp, 5 min and 30 min after declamp, respectively were compared among 3 groups AKBR was markedly decreased during the clamping period in all groups (P<0.05). In control and PGE groups AKRR was significantly increased after reperfusion than before clamp (P<0.05), but was significantly lower than before clamp. Thirty minutes after reperfusion in GSH group AKBR returned to normal level and was significantly higher than in control group (P<0.05). On light tnicroscopic examination of liver biopsy, mild swollen hepatocytes in the centrilobular zone were seen at ischemia and reperfusion in control and GSH groups, but nearly normal hepatic architectures in PGE group. These results suggest that glutathione has some benefical effect on protection of hepatic dysfunction, and PGE1 on protection of hepatocellular injury during hepatic ischemia and reperfusion.
Alprostadil* ; Biopsy ; Constriction ; Glutathione* ; Hemorrhage ; Hepatectomy ; Hepatocytes ; Ischemia* ; Liver ; Liver Transplantation ; Prostaglandins E ; Rabbits* ; Reactive Oxygen Species ; Reperfusion Injury ; Reperfusion* ; Warm Ischemia

No abstract available.
Sarcoma* ; Uterus*

No abstract available.
Gonadotropin-Releasing Hormone* ; Gonads* ; Steroids* ; Trophoblasts*

Although exercise electrocardiography is commonly used to determine the likelihood of coronary artery disease, data of exercise electrocardiography are limited in Korea. Authors reviewed 409 patients with chest pain who underwent 12 lead treadmill exercise electrocardiography and coronary arteriography at Seoul National University Hospital from January, 1984 through September, 1990. All the patients underwent catheterization within three months after having a standard Bruce protocol treadmill exercise test. None of them had prior myocardial infarction, valvular heart disease, cardiomyopathy, and complete left bundle branch block. The study subjects consisted of 208 patients, including 42 patients of coronary artery spasm, with no or insignificant fixed coronary artery stenosis(less than 50% narrowing of luminal diameter), and 201 with significant fixed stenosis. The results were as follows; 1) The sensitivity of treadmill exercise electrocardiography was 73.6%, and the specificity was 88.2%. Positive exercise test in coronary artery spasm was 21.4%. 2) With increasing the extent of coronary artery disease, the proportion of the patients with one-vessel disease who showed positive ST segment change of stage I increase. Most of the patients with one-vessel disease who showed positive ST segment change on stage I had 90% or more stenosis. 3) With increasing the extent of coronary artery disease, the proportion of the patients with positive ST segment change in multiple lead groups increased. 4) ST segment change appeared most frequently in lead group V4-V6 and next in lead group II III a VF regardless of involved arteries. 5) ST segment elevation in lead group V1-V3 or in I/aVL was usually associated with 90% or more stenosis of left anterior descending artery in one-vessel disease, but similar proportion of the patients was noted in multivessel disease. This suggests that ST segment elevation in lead group V1-V3 or in I/aVL is probably associated with severe ischemia, not a specific predictor of left anterior descending coronary artery disease.
Angina Pectoris* ; Angiography ; Arteries ; Bundle-Branch Block ; Cardiomyopathies ; Catheterization ; Catheters ; Chest Pain ; Constriction, Pathologic ; Coronary Artery Disease ; Coronary Vessels ; Electrocardiography* ; Exercise Test ; Heart Valve Diseases ; Humans ; Ischemia ; Korea ; Myocardial Infarction ; Phenobarbital ; Sensitivity and Specificity ; Seoul ; Spasm

BACKGROUND: Psoriasis is a common chronic skin disorder characterized by hyperproliferation of the epidermis, inflammatory cell accumulation and increased tortuosity and dilatation of dermal papillary blood vessels. Angiogenesis plays a major role in the pathogenesis of psoriasis, however the mechanism responsible is largely unknown. Recently, some studies have identified several angiogenic factors from psoriatic epidermis, including interleukin (IL)-8, vascular endothelial growth factor (VEGF), and basic fibroblast growth factor (bFGF). OBJECTIVE: This study was aimed to elucidate the roles of VEGF and bFGF in the pathogenesis of psoriasis. METHODS: Immunohistochemical staining for VEGF and bFGF was carried out on skin samples of 15 psoriatic patients, plus 5 normal skin samples as a control. The psoriatic skins were divided into early and fully-developed stages, and differences in their expression between the stages were examined. RESULTS: The expressions of VEGF and bFGF on both epidermis and dermal structures were significantly higher in psoriatic lesional skin than in normal control skin. There was no significant differences between early and fully- developed psoriatic skin lesions. CONCLUSION: These results suggest that VEGF and bFGF may play significant roles in the pathogenesis of psoriasis.
Angiogenesis Inducing Agents* ; Blood Vessels ; Dilatation ; Epidermis ; Fibroblast Growth Factor 2 ; Humans ; Interleukins ; Psoriasis ; Skin ; Vascular Endothelial Growth Factor A