Darier disease is an autosomal dominant manner, with complete penetrance and variable expressivity. The condition is caused by mutations in the ATP2A2 gene, which encodes SERCA2. Family history is often overlooked due to subtle clinical presentations and presentation is common at around 20 years of age.

Case Report:This is the case of a 79-year-old elderly female who presented with a three year history of intensely pruritic erythematous hyperkeratotic papules on the face, trunk, and all extremities aggravated by heat and sweating. She reported of similar skin lesions seen on her father and brother, however they were undiagnosed and not treated. Multiple medications, including Prednisone, topical steroids, and antibiotics, provided temporary relief. Skin punch biopsy was done which revealed Acantholytic acanthoma consistent with Darier’s disease. CBC, SGPT, SGOT, Alkaline Phosphatase, BUN, Creatinine, Lipid Profile, FBS were requested and she was managed with topical corticosteroids, isotretinoin, Urea 10% lotion, and oral anti-histamines.

Darier disease is an autosomal dominant genodermatosis caused by mutations in the ATP2A2 gene, often presenting during puberty with chronic symptoms like hyperkeratotic lesions and nail abnormalities. Diagnosis relies on clinical and histopathologic correlation, aided by family history, though variable expressivity can complicate it. Coexisting infections must be evaluated due to potential morbidity. Treatment options include systemic retinoids, immunomodulators, and topical therapies like retinoids and calcineurin inhibitors. Personalized therapies have shown promise. Patient education on trigger avoidance and genetic counseling is crucial for managing recurrence risk, while life expectancy remains comparable to the general population.

Human ; Female ; Aged: 65-79 Yrs Old ; Darier Disease ; Keratosis Follicularis

INTRODUCTION: Several studies have suggested that music has a significant effect on memory. Classical music has been studied extensively. However, there are studies on other types of music like binaural beats which involve the introduction of tones of different frequencies. This study aimed to determine the effects of binaural beats stimulation compared to classical music on memory among high school students. METHODS: This was a randomized single-blind controlled trial among senior high school students in a selected private school assigned to listen to either binaural beats stimulation or classical music to determine their effect on memory as measured by the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS). Pre- and post-intervention RBANS scores were compared within and between the two study groups. RESULTS: RBANS scores in both classical music and binaural beats stimulation groups improved with an increase of 20.58 ± 10.33 and 20.26 ± 12.06, respectively. The difference between the increase in scores was not significant. CONCLUSION Exposure to either binaural beats stimulation or classical music provided statistically and clinically significant increases in memory. Binaural beats stimulation increased memory to the same degree as classical music.