Background Nitrosamines (NAms) are highly carcinogenic and frequently detected in drinking water systems in China, indicating potential human health risk through drinking water. Objective To analyze the distribution of NAms in drinking water in Shanghai and to evaluate relevant human health risk. Methods A total of 94 samples of source water and 120 samples of finished water were collected in February (dry period) and August (wet period) of 2021 from 30 drinking water plants in Shanghai, and eight NAms were quantitatively analyzed by gas chromatography tandem mass spectrometry after solid phase extraction. Cancer risks for different age groups caused by NAms exposure through water were evaluated using Monte Carlo probabilistic method and carcinogens risk assessment model recommended by the United States Environmental Protection Agency. Results The concentrations of total NAms in source and finished water were 12.56-65.86 ng·L⁻¹ and 8.52-57.38 ng·L⁻¹, respectively. The average concentration of total NAms was higher in source water (33.50 ng·L⁻¹) than in finished water (22.07 ng·L⁻¹, P<0.05) during dry season, and lower in source water (16.90 ng·L⁻¹) than in finished water (21.02 ng·L⁻¹, P<0.05) during wet season. The average concentration of total NAms in source water during dry season was twice of that during wet season. The positive rate of N-nitrosodimethylamine (NDMA) was the highest (100%) among the eight NAms. The cancer risk of exposure to NAms in finished water in Shanghai was mainly from the ingestion route, which was mostly caused by NDMA. The cancer risk from exposure to NAms in water for children (median=4.32×10⁻⁵) was slightly higher than that for adults (median=3.34×10⁻⁵) and adolescents (median=2.27×10⁻⁵). The cancer risks of exposure to NAms in water for people of different ages were mainly (80% - 95%) at an acceptable level (1×10⁻⁶ - 1×10⁻⁴). Conclusion NAms contamination is positive in Shanghai’s drinking water and NDMA is the main contaminant. The removal of NAms in water by current water treatment process is season-dependent. The cancer risk of children exposed to NAms in water was slightly higher than that of adults and adolescents, but all at acceptable levels.

Background Nitrosamines, especially N-nitrosodimethylamine (NDMA), are highly carcinogenic and frequently detected in drinking water systems in China, indicating potential human health risk through drinking water. Objective This study aims to analyze the distribution of NDMA in urban drinking water around China and to evaluate relevant human health risk, thus providing recommendations for drinking water safety standards. Methods The database of China National Knowledge Infrastructure was searched using nitrosamines and drinking water as key words in Chinese, and PubMed was searched usingN-nitrosodimethylamine or nitrosodimethylamine or NDMA, drinking water, and China as key words in English for relevant literature published from January 1, 2000 to March 1, 2021. Eligible data were extracted to statistically analyze the spatiotemporal exposure levels of NDMA in raw and finished water serving Chinese cities. According to the health risk assessment model for carcinogens recommended by the United States Environmental Protection Agency (US EPA), the cancer risk via drinking water of NDMA in finished water was evaluated for different age groups and different regions. Results A total of 102 studies were retrieved, 21 of which met the inclusion criteria and were finally included. The NDMA concentrations in 347 raw water samples and 276 finished water samples were extracted and studied, with positive rates of 82.4% and 67.0%, levels of not detected (ND)-141 and ND-67.1 ng·L⁻¹, and the 95th quantiles of 51.4 and 32.1 ng·L⁻¹, respectively. The level of NDMA in raw water was higher than that in finished water in cities of East and North China (P<0.05). East China had the highest average concentrations of NDMA in raw and finished water (21.4 and 9.0 ng·L⁻¹ respectively). In East China, the average concentrations of NDMA in raw and finished water from 2018 to 2019 (5.9 and 6.1 ng·L⁻¹ respectively) were significantly lower than those from 2015 to 2017 (28.7 and 16.5 ng·L⁻¹ respectively) (P<0.05). The average concentration of NDMA in rivers, lakes, ponds, and streams as drinking water sources (20.8 ng·L⁻¹) was significantly higher than that in groundwater sources (8.0 ng·L⁻¹) and in reservoir sources (6.5 ng·L⁻¹) (P<0.05). The average concentration of NDMA in finished water with pre-chlorination (9.4 ng·L⁻¹) was higher than that without (6.0 ng·L⁻¹) (P<0.05). The cancer risk of NDMA through drinking water for children over 1 year old in China decreased with older age, and the risk of infants aged 1~<2 years (2.52×10⁻⁴) was 23 times higher than that of adults (1.09×10⁻⁵) (P<0.05). Conclusion Raw water pollution is the main source of NDMA in urban drinking water in China, and current water treatment technology can partially remove NDMA. The NDMA level in finished water of East China shows a downward trend in recent two years. The carcinogenic risk of NDMA via drinking water for children is higher than that for adults, and their health risk management needs to be strengthened. The study findings recommend 35 ng·L⁻¹ as the limit of NDMA water quality safety standard in China.

Background Bisphenol compounds are non-persistent environmental endocrine disruptors and frequently detected in drinking water systems, indicating potential human health risks through drinking water. Objective To establish and optimize a simultaneous determination method for 16 BPs in drinking water by online solid-phase extraction-ultra high-performance liquid chromatography-triple quadrupole mass spectrometry, in order to efficiently monitoring BPs in drinking water. Methods Candidate online solid-phase extraction conditions, chromatographic columns, mobile phase systems, mass spectrometry parameters, and other conditions were compared by chromatographic peaks of BPs, and processing conditions such as water sample preservation and pretreatment were optimized. The pH level of drinking water samples was adjusted and solid particles were removed. After extraction and purification by an online solid-phase extraction system, samples were detected by ultra-high performance liquid chromatography tandem mass spectrometry and quantified by isotope internal standard method. The proposed method was verified by pure water and terminal tap water, and evaluated by spiked recovery rate and relative standard deviation. Eighty-eight tap water samples from different regions of local pipeline network were collected for method application. Results For the 16 BPs, the calibration curves showed good linearity between 1.0 and 75 ng·L⁻¹ and the correlation coefficients were greater than 0.995. The detection limit of the method was less than 0.30 ng·L⁻¹, and the quantification limit of the method was less than 1.0 ng·L⁻¹. When the spiked concentrations for the 16 BPs were 5.0, 15, and 40 ng·L⁻¹, the average spiked recovery rates of the test substances were between (100 ± 10)%, and the relative standard deviations were all below 10%. In the method application to the local terminal water samples, the positive rates of bisphenol S (BPS), bisphenol A (BPA), and bisphenol AF (BPAF) were as high as 93.2%, 77.3%, and 29.5%, respectively. The concentrations of BPS were from not detected (N.D.) to 37.8 ng·L⁻¹, and the concentrations of BPA were from N.D. to 52.0 ng·L⁻¹. Conclusion The method using an online solid-phase extraction system is established, featuring simple pre-treatment, small sample volume, high degree of automation, low detection limit, and good accuracy and precision. This method can be applied to the quantitative monitoring of 16 BPs at ng·L⁻¹ level in drinking water.