AIM: To evaluate the efficacy and safety of multiple vitamin E, C, B facial mask for the patients with acne vulgaris. METHODS: One hundred and seventeen patients aged over 13 a, with acnes mainly sited on the face and an acne severity rating above grade 2 were enrolled in this study. The mask treatment was used once a day with 8 wk as a course.The primary endpoint included the number and the degree of acne lesions including comedoes, papules, pustules and cysts. The secondary endpoint was the overall efficacy evaluation by the physicians. RESULTS:After 8 wk of treatment with multiple vitamin E, C, B facial mask, the mean number of acne lesions:comedoes, papules, pustules and cysts decreased 13 + s 13,10 ± 12, 5 + 7 and 3 + 3, respectively. These changes were statistically significant (P ＜ 0.01 ). The results of overall efficacy evaluation showed that 7 patients '(6.0 % ) symptom was greatly improved, 44 patients '(37.6 % ) symptoms were moderately improved, 56patients'(47.9 % ) symptoms were slightly improved,and 10 patients' symptoms did not change. Among all 117 patients, 59 patients (50.4 % ) showed no adverse reactions, including swelling, redness, itching,burning or scaling. CONCLUSION: Multiple vitamin E, C, B facial mask is efficacious for the treatment of acne and more than half study subjects experienced in none adverse reaction. Multiple vitamin E, C, B facial mask possesses an alternate therapy in acne vulgaris.

Objective To study the levels of serum acute-phase proteins,interleukin-6(IL-6) and tumor necrosis factor-?(TNF-?) in different stages of diabetic nephropathy in type 2 diabetes mellitus(T2DM) and to explore the clinical significance.Methods One hundred and five patients with T2DM diagnosed by WHO(1999) criteria were divided into three subgroups according to their urinary albumin excretion rate(UAER): 34 cases normal UAER group(NA group),31 cases microalbuminuria group(MA group) and 30 cases clinical proteinuria group(CA group).Thirty-three healthy individuals were selected as controls(NC group).The levels of acute-phase proteins including C reactive protein(CRP),?_1-acid glycoprotein(?_1-AAG),ceruloplasmin(CER) and haptoglobin(THP) were measured with immunoscattering assay,The levels of IL-6 and TNF-? were detected with electrochemiluminescence immunoassay.Results The levels of serum acute-phase proteins,IL-6,TNF-? were significantly higher in patients with T2DM than those in NC group(all P