Objective: To investigate the association between acute global coronary event registration(GRACE) risk score and laboratory parameters in patients with acute myocardial infarction(AMI). Methods: A retrospective analysis of 128 patients with AMI who admitted in Wenling Hospital of Traditional Chinese Medicine from May 2014 to May 2016 was performed.Among them, 86 patients with ST-segment elevation myocardial infarction were included in A group, and 42 patients with non-ST-segment elevation myocardial infarction were included in B group.According to the GRACE score at admission, they were divided into low, medium and high risk groups.The correlation between the patients' GRACE score and laboratory indicators was analyzed. Results: There were statistically significant differences in gender, alcohol consumption, age, PRBC and GRACE scores between A group and B group(χ²=4.071, 4.096, t=3.594, 2.378, 2.657, all P<0.05). According to age, GRACE and PRBC, the area under the ROC curve was 0.738(95% CI: 0.603~0.765, P<0.05). The male, smoking, drinking, age, D-dimer, PRBC, FDP, RDW and MCV had statistically significant differences among the low, medium and high risk groups(χ²=8.225, 11.450, 3.739, F=73.311, 146.980, 86.414, 10.512, 3.981, 5.786, all P<0.05). The correlation analysis showed that the GRACE score had positive correlation with age, MPV, PCT, MCV, RDW, PRBC, FDP and D-dimer (r=0.712, 0051, 0.128, 0.134, 0.039, 0.157, 0.279, 0.286, all P<0.05). The multiple linear regression analysis showed that the independent risk factors for GRACE scores were age and FDP. Conclusion There are significant differences in age, gender, drinking history, PRBC and GRACE scores between ST-segment elevation myocardial infarction patients and non-ST-segment elevation myocardial infarction patients, and there is a significant correlation between GRACE scores and laboratory test indicators.