Objective To evaluate the influence of preoperative quitting time on coronary artery bypass grafting (CABG) patients with postoperative hypoxemia incidence.Methods 151 patients with coronary bypass surgery and preoperative history of smoking who preparation of CABG in hospital were recruited from September 2011 to September 2013.According to the preoperative smoking cessation time patients were divided into five groups:0 days,1-30 days,31-60 days,61-90 days,more than 90 days.Single factor regression and Logistic analysis were used to analyse the influence of preoperative quitting time on CABG patients with postoperative hypoxemia incidence.Results Age,weight,smoking habit,quitting time,hypertension,diabetes mellitus were risk factors of hypoxemia after coronary artery bypass grafting.Logistic regression analysis showed that age,body weight,smoking habit,smoking time were independent risk factors of hypoxemia after coronary artery bypass grafting.The incidences of hypoxemia of the five groups 0 days,1-30 days,31-60 days,61-90 days and more than 90 days were 55.56％ (15/27),59.26％ (16/27),27.58％ (8/29),22.73％ (5/22),15.63％ (5/32).The incidence of hypoxemia had significant difference (x2=19.212,P ＜ 0.05).Conclusions Age,weight,smoking habit,quitting time were independent risk factors of hypoxemia after CABG.With the quitting time increase,hypoxemia after CABG overall downward trend.Difference quitting time before the operation,the hypoxemia occurred difference rate influence,On the preoperative smoking CABG patients were smoking cessation intervention timely helps to reduce the occurrence of postoperative hypoxemia.

Objective To investigate the effect of synthetic intervention on community re-entry of outpatients with schizophrenia. Methods Two hundred and eighty-four patients were randomly assigned to the intervention group (n = 143 ) and the control group (n = 141 ). The participants in the intervention group received mental health education, medication consultation, skill training and family-based psychological intervention for 1 year. The control group was followed up through clinic visits. At baseline,half a year and the end of the year,all the subjects completed the Social Support Rating Scale (SSRS) and the Positive and Negative Syndrome Scale (PANSS). Results The scores of SSRS and PANSS at baseline were not significantly different between the two groups. At the end of the year,the score of SSRS (32. 85 ± 12. 18) ,the objective support subscale (9. 15± 4. 18 ) ,the subjective support subscale ( 16. 92±7. 34) and the support utility subscale (6. 77±2. 09 ) in the intervention group were significantly increased when compared with the control group ( 31.05±8. 35,7. 77±4. 36,13.46±7.87,6. 23±2. 12, all P < 0.05 ). The score of PANSS (38. 88 ±9. 58 ), the positive subseale (7.40 ±1.12 ), the negative subscale ( 11. 32±5.92 ) and the general psychopathology subscale (20. 16±5. 19 ) in the intervention group showed significant difference with the control group (46. 88 ±16. 37,8.60 ±3. 19,13.52±7. 81,24. 76±8. 08 ,all P <0. 01 ). At the end of the year,the relapse of psychotic symptoms in the intervention and the control group was 18. 18% and 34. 75% ,respectively ( χ2 = 10. 03, P < 0. 01 ). Conclusion The study results suggest that synthetic intervention could be effective for schizophrenic outpatients in community re-entry.

Objective To investigate the effect of Six Sigma management application by pediatric nurses on needle-stick injuries. Methods A total of 35 pediatric nurses applied Six Sigma management, utilized brainstorming, cause and effect diagrams, charts Plato and quality management tools during September 2012 to August 2014. The needle-stick injury rates, mastery of theoretical knowledge and professional skills of vein puncture protection operations before and after applied Six Sigma management were compared. Results After applied the Six Sigma management, Sigma level (Z value) of needle-stick injuries increased to 3. 86 from 3. 49, and needle-stick injuries rate was lower than before (P <0. 01). After Six Sigma management, the nurses′theoretical knowledge of occupational protection, venipuncture skills and examination scored improved significantly (P<0. 01). Conclusions Six Sigma management can effectively enhance the protection awareness of needle-stick injuries and reduce the incidence of needle-stick injuries.

Objective To investigate the psychological experience of patients with depression before coronary artery bypass grafting(CABG).Methods With the phenomenological research method in qualitative research, deep semi-structured interview was conducted to 14 patients, who would be treated with CABG in two Class Ⅲ grade A hospitals in Luoyang, with the data analyzed and summarized by the 7-step analytical method of Colaizzi.ResultsThe psychological experiences of patients with depression before CABG included two themes: negative psychological experience and positive psychological experience.Conclusions Psychological experience of patients with depression before CABG is complicated and fickle. Medical workers should pay attention to both their negative emotions and positive performance.

Many people affected by fragile X syndrome (FXS) and autism spectrum disorders have sensory processing deficits, such as hypersensitivity to auditory, tactile, and visual stimuli. Like FXS in humans, loss of Fmr1 in rodents also cause sensory, behavioral, and cognitive deficits. However, the neural mechanisms underlying sensory impairment, especially vision impairment, remain unclear. It remains elusive whether the visual processing deficits originate from corrupted inputs, impaired perception in the primary sensory cortex, or altered integration in the higher cortex, and there is no effective treatment. In this study, we used a genetic knockout mouse model (Fmr1^KO), in vivo imaging, and behavioral measurements to show that the loss of Fmr1 impaired signal processing in the primary visual cortex (V1). Specifically, Fmr1^KO mice showed enhanced responses to low-intensity stimuli but normal responses to high-intensity stimuli. This abnormality was accompanied by enhancements in local network connectivity in V1 microcircuits and increased dendritic complexity of V1 neurons. These effects were ameliorated by the acute application of GABA_A receptor activators, which enhanced the activity of inhibitory neurons, or by reintroducing Fmr1 gene expression in knockout V1 neurons in both juvenile and young-adult mice. Overall, V1 plays an important role in the visual abnormalities of Fmr1^KO mice and it could be possible to rescue the sensory disturbances in developed FXS and autism patients.
Animals ; Disease Models, Animal ; Fragile X Mental Retardation Protein/metabolism* ; Fragile X Syndrome/metabolism* ; Humans ; Mice ; Mice, Knockout ; Neurons/metabolism*