1.A case analysis of conservative treatment of a cesarean scar pregnancy combined with uterine apoplexy
Yue WU ; Aihua WANG ; Chaohong HAN ; Xin FENG
Journal of Pharmaceutical Practice 2016;34(6):552-555
Objective To study the conservative treatment for cesarean scar pregnancy (CSP) with proper medications . Methods One case of CSP with uterine apoplexy was reported .Medication regimens were illustrated as the conservative treat-ments for the patient with β-HCG>20 000 IU/L ,in whom surgery was contraindicated .Results After two times of uterine artery embolization and chemotherapy (MTX50 mg) ,followed by three times of MTX50 mg cervical injection combined with oral mifepristone ,serumβ-HCG dropped to normal level and no adverse reactions were observed .Conclusion Clinical pharma-cists could strengthen the safety and effectiveness of rational drug use by participating in the integrated pharmacy care .
2.Efficacy of eltrombopag on recurrent connective tissue disease related thrombocytopenia patients who failed to respond to rhTPO or recombinant human thrombopoietin: a report of 4 cases and literature review
Yimaiti KUERBANJIANG ; Fan ZHANG ; Yamei SHI ; Yan ZHONG ; Chaohong YUE ; Jing LI ; Lijun WU
Chinese Journal of Rheumatology 2023;27(11):746-751
Objective:To evaluate the efficacy and safety of eltrombopag standard therapy in the treatment of patients with connective tissue disease (CTD) associated with thrombocytopenia who were non-responder to recombinant human thrombopoietin (rhTPO) or relapsed after discontinuation of rhTPO.Methods:Retrospectively analysis of clinical data of 4 cases presented with CTD associated with thrombocytopenia who were non-responder to rhTPO or relapsed after discontinuation of rhTPO, and then treated with eltrombopag from November 2017 to June 2022. The literature were reviewed on eltrombopag in the treatment of CTD associated with thrombocytopenia.Results:The platelet count of 4 patients increased to more than 30×10 9/L after 2 weeks administration of eltrombopag. The median time was 32 (14, 41) days for platelet counts returning to normal level. The dosage of eltrombopag was gradually reduced to maintain normal platelet count, which was helpful for tapering of glucocorticoid and other immunosuppressant. No adverse event was observed during the treatment. Conclusion:Eltrombopag is safe and effective for CTD associated with thrombocytopenia, for patients who are non-responders to rhTPO or relapsed after discontinuation of rhTPO treatment in particular.