Objective:To establish surgical difficulty scoring system of partial nephrectomy based on holographic imaging and explore its application value in partial nephrectomy.Methods:A total of 184 patients including 110 males and 74 females with renal tumors diagnosed as stage cT 1 to cT 2 before surgery in the First Affiliated Hospital of Xiamen University from October 2019 to January 2022 were included. Among the 184 patients, 141 patients were treated with partial nephrectomy and 43 patients were treated with radical nephrectomy (3 partial nephrectomies were finally changed to radical nephrectomies due to vascular and tumor location). 60 patients had hypertension. 24 patients had diabetes. 7 patients had hyperuricemia. The median age was 55(47, 62) years. The median BMI was 23.7(21.8, 26.4) kg/m 2. The median maximum tumor diameter was 3.9(2.9, 5.2) cm. The median preoperative eGFR was 99.7(83.4, 114.2) ml/(min·1.73m 2). The median R. E.N.A.L. score was 8(6, 9). The median PADUA score was 9(8, 10). 153 patients were diagnosed as stage cT 1 and 31 patients were diagnosed as stage cT 2. The hologram reconstruction was performed according to preoperative CT or MRI examination. The maximum diameter of the tumor in the kidney (D), the compression degree of the renal segmental vessels by tumor(C), the area of the renal sinus occupied by tumor(O) and the mass of exophytic rate(M) were comprehensively considered and finally constituted the difficulty scoring system named DCOM score for partial nephrectomy. The DCOM score divided the complexity of tumor surgery into mild (4-6 points), moderate (7-8 points) and high (≥ 9 points). Meanwhile, the MIC (surgical margins are negative, WIT is <20 min, and no major complications)was used to evaluate the overall surgical effect. The DCOM, R. E.N.A.L. and PADUA scores were performed on all patients and compared with each other to evaluate the surgical effect of DCOM score in partial nephrectomy. Results:All surgeries in this study were successfully completed, including 141 partial nephrectomies and 43 radical nephrectomies. The DCOM score was 10(9, 11) for radical nephrectomy and 6(5, 8) for partial nephrectomy, and the difference was statistically significant ( P=0.001). There were 23 patients (37.7%) in highly complex group, 39 patients (88.6%) in moderately complex group and 79 patients (100.0%) in mildly complex group underwent partial nephrectomy, respectively. According to multifactorial analysis, patients in highly and moderately complex group of DCOM score had 8.88 times ( P=0.001) and 1.76 times ( P=0.005) less reach MIC than those in mildly complex group, respectively. Patients in highly and moderately complex group of PADUA score had 4.86 times ( P=0.005)and 3.41 times ( P=0.006)less reach MIC than patients in mildly complex group of DCOM score, respectively. What’s more, patients in moderately complex group of R. E.N.A.L. score had 3.11 times ( P=0.003) less reach MIC than patients in mildly complex group of DCOM score. In the ROC curves to predict MIC achievement, the AUC values of R. E.N.A.L., PADUA and DCOM scores were 0.657, 0.655 and 0.746, respectively. Comparing:R. E.N.A.L. score with DCOM score, the AUC value was statistically significant ( P=0.025). Conclusions The surgical difficulty scoring system (DCOM score) based on holographic imaging can predict the outcome of partial nephrectomy, but further verification is needed.

【Objective】 To explore the efficacy of negative pressure ureteral access sheath combined with disposable flexible ureteroscope (UAS+FRUS) in the treatment of renal calculi of 2-3 cm, so as to provide reference for the treatment. 【Methods】 A retrospective analysis was conducted on 130 cases of renal calculi of 2-3 cm treated with surgery in Xiamen Third Hospital during Sep.2021 and Sep.2023, including 68 cases with UAS+FRUS and 62 cases with super-mini percutaneous nephrolithotripsy (SMP).The perioperative indexes and stone-clearance rate (SFR) were compared between the two groups. 【Results】 All operations were successful.There were no statistically significant differences in the total SFR and incidence of complications (5.88% vs. 9.67%) between the two groups 3 days (88.24% vs. 90.32%) and 1 month (91.18% vs. 93.55%) after surgery (P>0.05).For patients with lower calyceal calculi with infundibulopelvic angle (IPA)<45°, the SFR of the UAS + FRUS group was significantly lower than that of the SMP group (57.14% vs.100%, P<0.05).The UAS + FRUS group had a longer operation time than the SMP group \[(104.94 ± 8.79) minutes vs. (77.98±6.60) minutes, P<0.001\], higher hospitalization costs \[(23 112.82±1152.34) yuan vs. (21 975.84±1512.24) yuan, P<0.001\], less postoperative decrease in hemoglobin \[(6.71±2.07) g/L vs. (9.81±4.80) g/L, P<0.001\], and shorter postoperative hospitalization time \[(3.28±0.51) d vs. (5.58±0.71) d, P<0.001\].The UAS + FRUS group had lower postoperative VAS score at 6, 24, and 48 hours than the SMP group \[(6.38±0.69) vs. (7.87±0.88); (3.62±0.73) vs. (5.81±0.83) and (3.12±0.33) vs. (3.81±0.60)\], with statistical significance (P<0.05). 【Conclusion】 Both surgical methods have a high SFR in the treatment of renal calculi of 2-3 cm.SMP has the advantages of short operation time, low hospitalization costs, and high SFR for lower calyx calculi, while UAS+FURS has the advantages of little bleeding, minimal trauma, and short hospital stay.Surgeons can make reasonable choices based on the patients’ condition and willingness, combined with their own surgical experience.