As to clarify the cause of cervical cancer,early normative and effective screening can decrease the incidence and mortality of precancerous cervical lesions and cervical cancer.At present the main methods for cervical cancer screening are pap smear method,acetic acid shading to naked eye observation,iodine staining to the naked eye observation,liquid based cytology and human papillomavirus DNA testing methods.Screening techniques and strategies are different in different areas and countries because of unbalanced economic development.

A MSP430-based detection project of blood pressure (BP) is put forward, in which the application of the portable monitor is taken into considerations. High- precision sensors and parameter recognition are also involved in. BP parameter extraction and real-time control of the system are discussed in detail.

Animals ; Carcinoma, Hepatocellular ; genetics ; virology ; Hepatitis B, Chronic ; complications ; Hepatitis C, Chronic ; complications ; Humans ; Liver Neoplasms ; genetics ; virology ; Neoplasm Recurrence, Local ; genetics ; Point Mutation ; Telomerase ; metabolism

MicroRNA (miRNA) is a kind of naturally occurring short non-coding small molecular RNA,which regulates gene expression at the posttranscriptional level through its sequence complementation with target mRNAs.Researches have shown that different malignant tumors,including diffuse large B cell lymphoma,have specific miRNA expression profiles.Therefore,miRNAs expression level of specimens of body fluids and tissues is expected to be the new indicator for assessing diffuse large B cell lymphoma.

Objective To investigate the stability of lumbar column after limited selective posterior rhizotomy(LSPR) and observe the healing of exscinded laminae and the deformation of lumbar column. Methods One hundred and twenty five children with spastic cerebral palsy were divided into six groups(A, B, C, D, E, F)according to the age(

[Summary] The theory of fetal origins of adult disease (FOAD) is now widely accepted by researchers who hold the opinion that adult degenerative and metabolism diseases have close relationship with the environment of fetal development inside and outside the womb. Some studies have proved that maternal hypothyroidism can negatively affect the glucose metabolism of their offsprings. However, the whole mechanism is not clear yet. Insufficient thyroid hormone during pregnancy was proved to slow down the formation of fetal pancreatic cytoskeleton, to decrease the proinsulin gene transcription, and to modulate series of cytokines and enzymes which are related to glucose dependent insulin secretion. Thyroid hormone receptor is also considered to be partially responsible for the relation between low thyroid hormone and β cell insufficiency. However, more studies in vivo should be carried out to prove this hypothesis. Epidemiologic studies have suggested that type 2 diabetes and low birth weight can be different phenotypes of the same genotype. The definite mechanism of maternal hypothyroidism in influencing fetal β-cell function should be studied by further investigation.

Objective To discuss the correlation between nature of carotid plaque by dual-source CT examination and serum levels of hypersensitive C-reactive protein (hs-CRP),lipoprotein a (LPa) and homocysteine (Hcy),and provide a better theoretical basis for the prevention and treatment of ischemic cerebrovascular disease.Methods Fifty carotid plaque patients with ischemic cerebrovascular disease symptoms (group A),50 carotid plaque patients without ischemic cerebrovascular disease symptoms (group B)and 50 healthy people (group C) were selected.All objects were detected the carotid plaque by dual-source CT,and the serum levels of hs-CRP,LPa and Hcy were detected by the automatic biochemical analyzer.The correlation between the nature of carotid plaque by dual-source CT examination and the serum levels of hs-CRP,LPa and Hcy was analyzed.Results The total number of carotid plaque,number of unstable plaque and number of stable plaque in group A were 357,220 and 137 pieces,respectively.Those in group B were 200,13 and 187 pieces,respectively.There were statistical differences between group A and group B (P ＜ 0.01).Patients in group A and group B were mainly with unstable plaque and stable plaque,respectively.Healthy people in group C were without carotid plaque.The serum levels of hs-CRP,LPa and Hcy in group A were (36.74 ± 13.22) mg/L,(563.15 ± 178.69) mg/L and (40.15 ± 12.31) μ mol/L,respectively.These in group B were (12.36 ± 4.35) mg/L,(393.56 ± 86.45) mg/L and (29.45 ± 7.63) μ mol/L,respectively.These in group C were (3.26 ± 1.26) mg/L,(220.17 ± 35.24) mg/L and (14.32 ± 2.44) μ mol/L,respectively.The serum levels of hs-CRP,LPa and Hcy in group A were significantly higher than those in group B and group C,and those in group B were significantly higher than those in group C,there were statistical differences (P ＜ 0.05).The serum levels of hs-CRP,LPa and Hcy were positive correlation with the number of carotid unstable plaque,the correlation coefficients between the serum levels of hs-CRP,LPa and Hcy and the number of carotid unstable plaque in group A were 0.469,0.398 and 0.363 (P ＜ 0.05),respectively,in group B were 0.276,0.145 and 0.127(P ＜ 0.05),respectively.The correlation coefficients between group A and group B were significantly different (P ＜ 0.05).Conclusions The combination of dual-source CT examination and the serum levels of hs-CRP,LPa and Hcy is more beneficial to judge the stability of plaque,and it can help predict the nature of the carotid plaque.This view is important clinically for the prevention and treatment of the occurrence and the development of the ischemic cerebrovascular disease.

Objective:To analyze the pathologic types and clinical characteristics of lymphoma in Shandong, China. Methods:The clinical data of lymphoma patients admitted from September 2011 to September 2014 in Shandong Cancer Hospital and the Affiliat-ed Hospital of Shandong Academy of Medical Sciences were retrospectively analyzed. Data included age, sex, pathologic classification, and onset locus of lymphoma. Results:The clinical data of 520 lymphoma cases were collected. The ratio of male to female was 1.2:1, and the median age was 51 years old. Among these patients, 67 cases (12.9%) were Hodgkin's lymphoma (HL), whereas 453 cases (87.1%) were non-Hodgkin's lymphoma (NHL). Among NHL cases, 75.9% were B-cell NHL and 24.1% were T/ natural killer-cell NHL. Nodular sclerosis classical Hodgkin's lymphoma was the most common pathologic type of HL, comprising 52.2%. The age of HL onset did not present twin peaks. In NHL, 245 cases (54.1%of NHL) were diffuse large B-cell lymphoma (DLBCL). The constituent ra-tio of DLBCL was higher than in other countries and regions (18%to 42.7%), in which the ratio of male to female was 0.9:1, and the age of onset was slightly earlier (median age was 54 years old). Lymph nodes in the cervical region were the most commonly involved in the disease, and NHL extranodal onset was frequently observed. Conclusion:Among the 520 cases of lymphoma, DLBCL is the most common subtype. Most subtypes show male predominance, but female predominance was observed for DLBCL. The commonly involved sites of extranodal lymphoma are the nasal cavity and gastrointestinal tract.

Neuromyelitis optica spectrum disorder (NMOSD) is an autoimmune disease of the central nervous system that is characterized by inflammatory demyelinating lesions and axonal degeneration in optic nerve and spinal cord. It has high relapse rate and high disability rate. In recent years, as the studies on mechanisms of NMOSD, related immune therapy strategies have been developed rapidly. These immunologic interventions are collectively called the disease modifying therapy, which are helpful in improving the course and outcome of the disease. In this review, the latest treatment progress in NMOSD is summarized to guide clinical choice and application of the medication.

Objective To know the problems of reference factors,and then provide evidences for scientific and specific identifying index system for students from poor families.Methods Questionnaires were used among 719 students from poor families.Results There were 86.0％ families whose earnings were lower than 410 RMB per month.57.2％ families depended on agriculture.70.1％ students were from the rural areas.Family member number was 4～6 for the majority ( 70.7％ ).91.2％ ( 94.5％ ) fathers'( mothers' ) education levels were under high middle school.64.0％ ( 67.3％ )fathers ( mothers ) were farmers.The proportion of students having computers was 76.1％.61.2％ students' life was not frugal.There were 80.9％ students who thought campus cards shouldn't be monitored.Conclusion Family economic situation should be the key indicator.Most of the basic family information could be reference factors.Basic situation of students at school was inappropriate to be reference factors.