Insulin deficiency is a key factor involved in the pathogenesis of diabetes. Apoptosis is one of the reasons for the lose of islets. The whole process of apoptosis is quite complex. This article summarizes the role of several factors such as glucose, free fatty acid, GLP-1, and in the islets apoptosis.

The purpose of the medical moral education is to make medical undergraduates form stable feature of the medical moral education psychology.While the traditional medical moral education has not been achieving the aim.Many studies of psychology has presented that it is important for study,training and medical moral of medical undergraduates by using implicit learning.In order to achieve the aim and ensure the result of medical moral education.we should take advantage of implicit learning to develop the medical moral education.

The levels of urinary neopterin in 30 patients with SLE were determined by reversed-phase high performance liquid chromatgraphy(HPLC). The results showed: (1 ) the levels of urinary neopterin in 30 patients with SLE were significantly higher than those in 20 controls. (2) The concentrations of urinary neopterin in SLE patients were significantly correlated with the disease activity, they decreased after efficacious treatment with reduced disease activity. (3) There was significant positive correlation between urinary neopterin concentration and erythrocyte sedimentation rate, but there were no statistical relations between urinary neopterin levels and ANA, antibody to ds-DNA, or plasma C3 levels. These results indicate that urinary neopterin may be used as an index for the assessment of disease activity in patients with SLE and monitoring therapeutic effect.

This article introduced the rich resources of medicinal pteridophyte and its conditions of geographic distribution,morphologic and cultural characteristics.Through the investigation,resource collecting and protection test on the important medicinal pteridophyte in Guzhou,it discussed the conservation and utilization of medicinal pteridophyte medicinal pteridophyte in Guzhou,and provided evidence for resource protection of further reasonable exploitation.

Bone Marrow Neoplasms ; Humans ; Leukemia, Myeloid ; Proto-Oncogene Proteins c-cbl

Objective To investigate the influence of obstetric complications and pregnancy outcome because of prenatal anxiety and depression.Me~ods One hundred primipara were selected as the research objects,their emotions were evaluated by Self-Rating Anxiety Scale(SAS),Self-Rating depression Scale(SDS).The patients' scores of SAS ≥50points or SDS ≥ 53points were selected as the observation group,the patients'scores of SAS ≥ 50points and SDS≥53points were selected as the control group.The pregnant women childbirth way,preeclampsia,hyperemesis gravidarum,gestational diabetes,perinatal infection,hydramnios,oligohydramnios,premature rupture of membranes,postpartum hemorrhage,fetal distress,premature birth,low birth quality,neonatal asphyxia of two groups were compared.ResultsThe primipara cesarean delivery rate of the control group was lower than that of the observation group(4.00％ vs 22.00％,x2 =7.161,P ＜0.05),the obstetric complications incidence of the observation group was higher than that of the control group (32.00％ vs 2.00％,x2 =15.946,P ＜ 0.05),the birth outcomes incidence of the observation group was lower than that of the control group (4.00％ vs 20.00％,x2 =6.061,P ＜ 0.05).Conclusion Prenatal anxiety and depression significantly increase pregnant women obstetric complications,increase the perinatal fetal intrauterine distress and the probability of premature birth,low birth quality and neonatal asphyxia.

Background Herpetic stromal keratitis (HSK) is an immunopathologic eye disorder mediated by CD4+ T lymphocytes.Interleukin-9 (IL-9) is a cytokine linked to the process of many immune inflammatory diseases,but whether IL-9 is involved in the immunopathology of HSK remains unclear.Objective This study was to investigate the expression of IL-9 in murine cornea during the development of HSK and its relationship with the degree of HSK.Methods One hundred and eighty clean BALB/c mice were divided into the normal control group (20 mice) and experimental group (160 mice).HSK models were established by scratching on the surface of the cornea followed by inoculation of 1 × 106 plague forming unit(PFU) herpes simplex virus type 1 (HSV-1) KOS strain.Change of ocular surface was examined under the slit lamp biomicroscopy before and I day,3,5,7,8,10,14,21 days after inoculation of HSV-1.The corneas of mice were collected on the time points mentioned above.The relative expression level of IL-9 mRNA in the cornea of mice was detected by real-time PCR.Immunocytochemical localization of IL-9 protein in murine cornea was viewed by a confocal microscope after preparation of the corneal cryostat sections.All experimental manipulations were undertaken in accordance with the institutional guidelines for the care and use of laboratory animals.Results Punctiform,dendriform or geographic defect in corneal epithelium were seen 3 days and healing 6 days after inoculation of HSV-1.However,edema and opacity of the corneal stroma appeared 7 days and peaked 14 days following the inoculation.Real-time PCR assay showed that very little of IL-9 mRNA (A260/A280) was expressed in the cornea in the mice of the control group.But in 1 day,3,5,7,8,10 and 14 days,the relative level of IL-9 mRNA was 6.37±0.45,5.66±0.53,3.93±0.35,3.62±0.34,3.23±0.18,2.57±0.14,2.19±0.20,with a significant difference among the various time points (F=92.764,P=0.000),and IL-9 mRNA in 1 day,3,5,7,8,10 and 14 days after inoculation was significantly higher than before inoculation (P＜0.05);while no markedly difference was found in IL-9 mRNA expression between the 21-day group after inoculation and the normal control group (P =0.340).IL-9 protein was expressed in the epithelial layer,stromal layer and endothelial cell layer of the corneas,with a stronger green fluorescence in the HSK mice,but no expression of IL-9 protein was seen in the control mice.Conclusions HSK model can be successfully created by corneal scratching and inoculation of HSV-1 KOS strain in BALB/c mouse.IL-9 is involved in the pathogenesis and development of HSK mediated by immunoresponse.