1.The Development of Medical Bilingual Teaching and its Model and Strategy
Xiaobo ZHANG ; Chao CHEN ; Guoying HUANG ; Yonghao GUI
Chinese Journal of Medical Education Research 2003;0(04):-
Bilingual teaching is a new measure to enhance the quality of education in universities and to meet the requirement for a WTO member.Conducting bilingual teaching in medical schools is to aim at cultivating high-quality doctors and improving Chinese medical science.This article interprets the concept and goal of bilingual teaching and analyzes the history and mode of bilingual teaching in China.The methods of conducting medical bilingual teaching,the construction of the teaching resource and the evaluation of the curriculum have also been discussed.
2.Clinical research on intravitreal injection of triamcinolone acetonide for treating macular edema caused by pre - retinal membrane of the macular
Gui-Lan, ZHANG ; Bo-Chao, SUN ; Ming-Jie, HUANG
International Eye Science 2014;(6):1151-1153
AIM: To evaluate the efficacy and complications of intravitreal injection of triamcinolone acetonide ( TA ) for the treatment of macular edema caused by pre-retinal membrane of the macular.
METHODS: Totally 23 patients ( 24 eyes ) with macular edema caused by pre-retinal membrane of the macular were treated withintravitreal injection of 4mg TA. Best-corrected visual acuity ( BCVA ) , intraocular pressure ( IOP ) , slit - lamp examination, fundus fluorescein angiography ( FFA ) and optical coherence tomography (OCT) were performed before and after treatment. The SPSS 12. 0 software was used for statistical analysis.
RESULTS: After 10, 30, 90d of treatment of TA, as compared with before treatment, visual acuity improved significantly ( P<0. 05 ), and central macular thickness (CMT) was significantly thinner (P<0. 01). The average central macular thickness decreased from 522 ± 126μm before treatment to 264±115μm, 245±128μm, 286±131μm at 10, 30, 90d after treatment. Macular edema reduced. IOP increased in 7 eyes ( 29%) , one cataract case, no other complications associated with vitreous injection.
CONCLUSION: Intravitreal injection of TA in the treatment of macular edema caused by pre - retinal membrane of the macular is simple, safe and easy to operate. It can quickly reduce macular edema, and improve the visual acuity in the short term. Part of patients may recur after injection in the first half of the year.
3.Study on dynamic change of serum interleukin-17 and interleukin-10 levels in patients with acute cerebral infar.
Chao-Gui ZHANG ; Chang-Hua QU ; Hua YANG ; Wan-Hong LIU
Chinese Journal of Applied Physiology 2014;30(1):36-37
Cerebral Infarction
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blood
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Humans
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Interleukin-10
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blood
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Interleukin-17
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blood
4.Zinc and IL-1beta concentration in serum and cerebrospinal fluid in children with febrile seizure.
Chao-Gui ZHANG ; Chang-Hua QU ; Hua YANG ; Wan-Hong LIU ; Xiao-Hua HE
Chinese Journal of Applied Physiology 2013;29(4):344-345
Child, Preschool
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Female
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Humans
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Infant
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Interleukin-1beta
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blood
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cerebrospinal fluid
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Male
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Seizures, Febrile
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blood
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cerebrospinal fluid
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Zinc
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blood
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cerebrospinal fluid
5.Construction of the Top-quality Course of Pediatrics
Xiaobo ZHANG ; Chao CHEN ; Guoying HUANG ; Yonghao GUI ; Yong ZENG ; Yingqing LU
Chinese Journal of Medical Education Research 2005;0(05):-
The article sums up the thinking and methods of the top-quality courses of Pediatrics constructed by the pediatric bed-sided teaching(PBL courses) and clinical training.The aim of the courses is to combine gradually lecture,question,discussion and practice,encourage active discussion,emphasize clinical ability and establish a new teaching method of pediatrics.
6.PBL Practice in Pediatrics Teaching
Xiaobo ZHANG ; Chao CHEN ; Guoying HUANG ; Yonghao GUI ; Yong ZENG ; Yingqing LU
Chinese Journal of Medical Education Research 2002;0(01):-
Pediatrics is a medical discipline,studying children health,growth and development,health care and disease prevention.To ignite medical students' interest in pediatrics,cultivate their creativity and ability in clinical practice,since February 2004,Pediatric Department in Children's Hospital of Fudan University has implemented the teaching pattern that combines traditional teaching practice with problem based learning(PBL) in students of seven-year medical training program,which has received positive feedback and wide approval from the students.
7.Construction of Pediatrics Curriculum in Conformance with New Medical Mode
Xiaobo ZHANG ; Chao CHEN ; Guoying HUANG ; Yonghao GUI ; Yingqing LU ; Yong ZENG
Chinese Journal of Medical Education Research 2003;0(02):-
Facing a transformation of society and new problems of health care system in the twenty-first century,traditional medical modals have many challenges.The new modes of modern medicine have been formed.The medical education reform must adapt new medical modes to cultivate high quality medical talents.And at the same time the course of pediatrics should be constantly innovated to construct the first class teaching staff,first-rank teaching contents,teaching methods,teaching material and teaching administration.
8.Influence of fast inhibition to virus replication on immune rejection and prognosis of acute-on-chron-ic livre failur e patients
Jin-zhang WANG ; Xiu-cheng PAN ; Xue-bing YAN ; Jun-gui HAO ; Yan-chao ZHANG ; Ling-yu NG ZE
Journal of Chinese Physician 2010;(z2):4-7
Objective To analyze the result of treatment for acute-on-chronic liver failure patients with fast high efficiency Nucleoside and to explore the relations among inhibition to virus replication , liver failure development and immune rejection .Methods Sixty-two cases of acute-on-chronic liver failure pa-tients with HBV DNA(+) were divided into study group (treated with a kind of fast and nucleoside , n =30) and control group( n =32).HBV DNA,CD4 +T,CD8 +T, C3,C4 TBIL,PTA were observed at treat-ment 0w,2w and 4w.Results All of the study and control group patients , serum HBV DNA were positive before treated.And the levels of CD4+,CD8 +,C3,C 4,TBIL,PTA of study group were not significantly compared with control group .At treatment 2w , the rate of HBV DNA diverted negative in study group 90.0%(27/30), was significantly more then control group (9.4%, 3/32)(χ2=37.14 , P <0.01).But the CD4 +,CD8 +,C3,C4,TBIL,PTA levels were not significantly however between study and control group . At treatment 4w ,the rate of HBV DNA diverted negative in study group (96.7%, 29/30), was significant-ly more then control group(12.5%,4/32) (χ2 =40.74, P <0.01).CD4 +, CD8 +,C3,C4,TBIL,PTA levels of the study group were significantly more compared with the control group .The CD4 +level of study group (495.33 ±89.91)cells/ml, was higher significantly then control group (270.34 ±97.74)cells/ml( t=9.42, P <0.01),the CD8 +level (571.03 ±120.15 ) cells/ml, was higher significantly then control group(224.88 ±79.68)cells/ml( t =13.45, P <0.01).The C3 level of the study group (0.28 ±0.11) g/L, was lower significantly then control group ( 0.68 ±0.13 ) g/L ( t =13.13 , P <0.01 ) , the C4 level (0.12 ±0.06)g/L, was lower significantly then control group (0.23 ±0.10)g/L( t =4.92, P <0.01). The TBIL level of study group ( 653.93 ±131.02 )μmol/L, was higher significantly then control group (285.63 ±154.63)μmol/L( t =10.09, P <0.01),the PTA level (17.13 ±7.07)%, was lower signifi-cantly then control group(50.94 ±13.68)%( t =12.10, P <0.01).The death rate of the study group( 57.9%) was higher significantly compared with the control group (28.1%)(χ2 =6.39, P <0.05).Con-clusion Treatment of chronic severe hepatitis with fast and high efficiency nucleoside may arise the T cell subset level and make the immune rejection strength , as a result the liver failure maybe far away from cure .
9.Inhibition effect of curcumin on the proliferation of ovarian carcinoma SKOV-3 cells
Gui-Xia SUN ; Gui-Xia ZHANG ; Chao GAO ; Juan XIE
The Chinese Journal of Clinical Pharmacology 2016;32(7):637-639
Objective To investigate the inhibitory effect of curcumin on the proliferation of ovarian carcinoma SKOV-3 cells.Methods The model group ( including regular SKOV -3 cells only ) , blank group ( adding amount of nutrient solution) and experimental group were set in experiment.And the experimental group were divided into 7 groups ( the final concentrations of curcumin were 5,10,20,40,80 μmol· L-1 , there are C1 -C5 groups; cisplatin group ( 10 μmol · L-1 ) , 20 μmol · L-1 curcumin+10μmol· L-1 cisplatin group ( combination group) and each were built 6 complex holes.The inhibition effect of curcumin on the pro-liferation of SKOV-3 cells was determined with methythiazolyldiphenyl-tetrazoliumbromide( MTT).The apoptosis rate was determined with PI.The effect of the cell cycle was determined with propidium iodide ( PI ) staining.The the expression of cells in the Bcl -2 protein was deter-mined with ELLISA.Results The curcumin can inhibit the growth of SKOV3, which showed dose -dependent and time -dependent.The apoptosis rate in the model group was 0.15%, the C1 -C5 groups in experimental group were 3.86%, 26.98%, 33.76%, 47.75%, 68.86%,respectively;the cisplatin group was 53.91%, the combinationgroup was 77.96%.The number of the SKOV-3 cells in G0-G1 stage is increasing, in G2-M stage an S stage are in decline with the increasing concentration of curcumin.And the apoptosis rate is increasing ( P<0.05 ).And the curcumin can inhibit the expression of the SKOV -3 Bcl -2 protein, which showed the dose -dependent.Conclusion The curcumin can inhibit the proliferation of SKOV-3, which is co-effected by the induction of apopto-sis and the promotion of the cell cycle arrest.