Objective To study the clinical efficacy and safety of clopidogrel combined with aspirin in doub-le loading dosage and ordinary dosage in the treatment of acute non -cardiac cerebral infarction.Methods A total of 110 patients with acute non -cardiac infarction were equally assigned into two groups,each group had 55 patients.The patients in group A were treated with clopidogrel 300mg and aspirin 300mg on the 1st day,and followed by clopidogrel 75mg and aspirin 100mg every day.Patients in group B were treated with clopdogrel 75mg and aspirin 100mg every day.Clinical efficacy and safety were evaluated in one week,NIHSS scores were evaluated,and adverse effects were recorded during treatment.Results After one week treatment,the deteriorate rates of group A and B were 12.7%, 18.2%.Compared with group B,group A had lower cerebral infarction deteriorate rate,but there was no statistically significant difference(P =0.429).After seven days treatment,the NIHSS score of A group had improved[(4.42 ± 3.34)points vs.(3.15 ±2.58)points],the difference was statistically significant(t =3.713,P <0.01 ),which in group B had no significant improvement[(4.16 ±2.76)points vs.(3.80 ±3.15)points,t =1.209,P =0.232].After seven days treatment,the NIHSS score improvement of group A was (1.27 ±2.54)points,which of group B was (0.36 ±2.23)points,the difference was statistically significant(t =1.994,P =0.049).No severe adverse effects occurred in both two groups.Conclusion Using clopidogrel combined with aspirin in double loading dosage may effectively attenuate stroke process and improve prognosis than ordinary dosage.Using clopidogrel combined with aspirin had no severe adverse effects in short -term treatment of acute non -cardiac cerebral infarction.