1.Clinical and imaging analysis of 8 cases with ipsilateral hemiparesis in ischemic stroke
Journal of Apoplexy and Nervous Diseases 2022;39(5):405-408
To summarize the clinical and imaging features of ipsilateral limb weakness caused by cerebral infarction,and to explore the possible physiological mechanism of the disease. Methods The clinical data of patients with ipside-limb weakness caused by acute cerebral infarction hospitalized in our department from January 1,2016 to December 30,2016 were collected,and the neurological symptoms and signs,magnetic resonance imaging (MRI) and other examination results of the patients were analyzed descriptively. Results 8 cases of ipsilateral hemiparesis (0.18%) were found in 4495 patients with acute cerebral infarction,all 8 patients were lacunar cerebral infarction,4 cases with previous medical history of cerebral infarction,3 cases have old infarcts in Contralateral cerebral hemisphere,DTI of 1 case showed pyramidal tract was not cross,the lesions of 2 cases were in the brain stem,2 cases in centrum semiovale,3 cases in capsule,One was in the putamen and one in the frontal cortex. Conclusion Most of the patients with ipside hemiparesis caused by cerebral infarction had a history of previous pyramidal tract injury,which was mostly lacunar lesions,mostly located in the configuration area of ipside-pyramidal tract.
2.Practice and exploration of cultivating scientific research ability of postgraduates with professional master of clinical medicine
Shangjing LIU ; Jing WU ; Tichun WANG ; Caishuang PANG ; Min TANG ; Changzhu DUAN
Chinese Journal of Medical Education Research 2022;21(4):402-406
This investigation was conducted on clinical professional graduate students of Chongqing Medical University to analyze the problems and influencing factors in the process of scientific research ability training. We propose three measures to improve the model of training professional clinical graduate students and provide references for the cultivation of their scientific research ability. The measures are "clear orientation of clinical scientific research ability training", "constant pursuit of high-level original scientific research results" and "adherent implementation to strengthen training effect".
3.Reform and practice of the evaluation of medical graduate students' scientific research ability cultivation under the background of breaking the "five-only": taking the top talent cultivation program as an example
Caishuang PANG ; Qingtao HOU ; Jing WU ; Changzhu DUAN
Chinese Journal of Medical Education Research 2024;23(2):191-194
The cultivation of graduate students' scientific research ability is an important task of colleges and universities. The evaluation standards of cultivation achievements play an important guiding role. In recent years, quantitative academic evaluation based on the "five-only" has caused some negative effects on the cultivation of talents in colleges and universities. A new evaluation system needs to be established. During the transition period between the old and new academic evaluation systems, the evaluation criteria for the cultivation of graduate students' scientific research capabilities will inevitably need to be reformed. This study attempts to reform the existing evaluation standards by investigating the evaluation standards for the cultivation of scientific research capabilities in various colleges and universities. The aim is to improve the evaluation of the achievements in the cultivation of scientific research ability of graduate students and improve the quality of the cultivation of scientific research ability of graduate students.
4.Relationship between exon 11 CAG triplet nucleotide repeats of myocyte enhancer binding factor-2A polymorphisms and ischemic stroke caused by large artery atherosclerosis
Feng WANG ; Zhongming YING ; Min ZHU ; Zhou ZHENG ; Xiaofei HU ; En WANG ; Changzhu WU ; Xinwei HE ; Weiling LI ; Cai LI ; Feng ZHU ; Xiaoping JIN
Chinese Journal of Neuromedicine 2017;16(12):1259-1264
Objective To investigate the relationship between exon 11 CAG triplet nucleotide repeats ([CAG]n) of myocyte enhancer binding factor-2A (MEF2A ) polymorphisms and ischemic stroke caused by large artery atherosclerosis (LAA). Methods Two hundred and five patients with first onset ischemic stroke caused by LAA, admitted to our hospital from June 2010 to December 2014, and 192 healthy controls were chosen in our study. The polymorphisms of exons 11 of MEF2A gene were genotyped by polymerase chain reaction-sequence-based typing (PCR-SBT). The relation of ischemic stroke caused by LAA with polymorphisms of (CAG)n was analyzed. Results Different (CAG)n alleles could be detected, with repeated sequences of 9-11. Frequencies for the different (CAG)n alleles in exon 11 CAG of MEF2A gene were not the same between the ischemic stroke patients and the controls (χ2=8.547, P=0.036). The distribution frequency of the (CAG)9 allele in the ischemic stroke group was significantly higher than that in the control group (χ2=6.650, P=0.010). Logistic regression analysis indicated that systolic pressure and (CAG)9 (OR=1.401, P=0.017, 95%CI: 1.063-1.847) were the independent risk factors of acute ischemic stroke caused by LAA. Conclusion The (CAG)n polymorphisms may be associated with ischemic stroke caused by LAA and the (CAG)9 allele may be one of the genetic susceptibility factors for this subtype of stroke.