Objective To explore the contribution of prenatal ultrasonic diagnosis to congenital digestive tract obstruction. Methods Prenatal ultrasonographic data of congenital digestive tract obstruction in 46 fetuses were retrospectively analyzed. Results Congenital digestive tract obstructions, including 1 esophageal atresia, 7 pyloric stenosis or atresia, 18 duodenal stenosis or atresia, 6 intestinal stenosis or atresia, 3 colonic atresia, 9 anal atresia and 2 congenital megacolon were proved with induced abortion or postnatal operation. Conclusion Prenatal ultrasonogrphy can directly depict the level and degree of digestive tract dilatation, therefore, is an important prenatal diagnostic modality of congenital digestive tract obstruction.