Objective To evaluate the application and efficacy of 6S quality management methods in drug clinical trials of oncology department.Methods By using 6S (Seiri,Seiton,Seiso,Seiketsu,Shitsuke,Safety) quality management methods,quality about mastering level of good clinical practice (GCP) knowledge,sample collection and drug management etc.were controlled,and efficacy after the quality control was evaluated.Results After implemention of 6S quality management,rate of achieving GCP certificate was increased to 77.80％,accuracy rate of sample collection and accuracy rate of medicine preparation were increased to 100.00％,and the rate of relearning study protocol was increased to 100.00％,and subjects' satisfaction was improved significantly.Conclusion The implementation of 6S quality management methods could effectively enhance the quality of drug clinical trials in oncology department.

Objective To explore the influence of the self-efficacy nursing on compliance behavior of patients with cervical cancer.Methods Totals of 153 patients from November 2012 to November 2013 diagnosed as uterine cervical neoplasms and treated by surgical procedure were selected, within which 86 patients joined the research and were divided into observation group and control group, 43 cases in each group. The control group was given the routine nursing care, and the observation group was given the self-efficacy nursing intervention on the basis of conventional nursing.The self-efficacy and compliance behavior were surveyed before and after the intervention.Results The scores of self-efficacy before the intervention had no statistically significant difference (t=0.158,P>0.05).After the intervention, the score of the observation group was (35.15 ±5.21), which was significantly higher than (21.26 ±8.26) of the control group ( t=15.684,P<0.01) .The score of self-efficacy of the observation group before and after the intervention were statistically significant (t=15.124,P<0.01), while the self-efficacy in the control group before and after the intervention had no statistically significant difference (t=1.245,P>0.05).After the intervention, the scores of compliance of medication, reasonable break, regular examination, healthy diet, abstain from tobacco and drink, reasonable exercise, prevention of infection and the total score were (2.85 ±0.41), (2.92 ±0.56), (2.81 ±0.44), (2.75 ±0.46), (1.87 ±0.41), (2.79 ±0.54), (2.88 ±0.39) and (18.75 ±1.65), which were significantly higher than those of the control group ( t=5.124, 6.235, 5.842, 4.963, 4.698, 5.148, 6.398, 5.458, respectively;P<0.01).Conclusions Self-efficacy nursing intervention can improve the self-efficacy of uterine cervical neoplasms patients, enhance patients’ self-management level, and enhance confidence on health compliance behavior.

Objective To investigate the value of self-management intervention based on the law of Ebbinghaus forgetting curve in hospitalized patients with gynecologic malignancies .Methods From October 2012 to March 2014 , 128 cases of gynecologic cancer patients admitted to our hospital were randomly divided into the observation group and the control group , with 64 cases in each group .The control group was treated with conventional self-management education .The observation group was taught by the self-management intervention according to the Ebbinghaus forgetting curve .The postoperative abdominal distention , nausea and vomiting and other symptoms were observed between the two groups seven days later after the operation .The time eating solid food, hospital stays, quality of life and patients satisfaction were compared .Results In the observation group , 10 patients (15.63%) had postoperative abdominal distention , 12 patients (18.75%) had postoperative nausea and vomiting, and the incidence and analgesic drug usage was 17.19%, which were significantly lower than those in the control group (χ2 =11.094, 10.152, 13.227, respectively;P<0.05).In the observation group, patients’ first time out of bed were (33.58 ±7.07) hours, the first flatus time was (39.79 ±1.22) hours, the first time eating solid food was (49.51 ±8.48) hours, and the length of hospital stay was (10.55 ±3.62) days, which were significantly lower than those in the control group (t=2.261, 7.411, 9.584, 2.019, respectively;P<0.05).The score of QOL-BREF one month after surgery in the observation group was (66.88 ±5.61), which was significantly higher than (49.64 ±5.54) in the control group (t =8.146,P <0.05).The patients satisfaction in the observation group was (91.08 ±3.63), which was significantly higher than (63.52 ±4.05) in the control group (t=11.521,P<0.05).Conclusions Based on the Ebbinghaus forgetting curve regular self-management interventions for patients with gynecological malignancies can significantly reduce the incidence of postoperative chemotherapy and adverse events , and promote functional recovery of patients and improve their quality of life .And the self-management education with scientific guidance can help consolidate the effect of self -management education .

Objective To investigate the impaction of health education with PDCA model combined with ABC management on compliance and quality of life in patients with ovarian cancer chemotherapy . Methods Totals of 124 ovarian cancer patients were selected from May 2011 to December 2013 in our hospital . Patients were randomly divided into observation group and control group , with 62 cases in each group .The control group was given general health education , and the observation group was treated by PDCA model combined with ABC management .The compliance , quality of life and treatment satisfaction were compared between the two groups .Results In the observation group , the medication compliance , nutritional support , functional training and rehabilitation of compliance were significantly better than those in the control group (χ2 =8.382, 7.225, 7.314, 10.098, respectively;P<0.01).The difference of quality of life at admission was not significant (P>0.05).After one-year treatment, the score of quality of life was (66.75 ±5.42) in the observation group and (49.55 ±5.17) in the control group.The difference was statistically significant (t=9.251,P<0.05).The satisfaction score in the observation group was (91.35 ±3.48) and (63.53 ±4.12) in the control group.The difference was statistically significant (t=11.521,P<0.05).Conclusions The health education with PDCA model combined with ABC management can improve the quality of life in patients with ovarian cancer .It can also strengthen the cooperation between nurses and patients , so that patients′satisfaction is improved.

Objective To study the effect of transitional care program involving group activities on self-efficacy in patients with cervical cancer. Methods A total of 34 cases from October 2013 to March 2014 in our hospital diagnosed with cervical cancer in parallel comprehensive treatment were selected as the observation group patients, and 34 cases from January to June in 2013 in our hospital diagnosed with cervical cancer in parallel comprehensive treatment were selected as control group. The control group was given routine nursing, while the observation group was given the transitional care program involving group activities. The general self-efficacy table ( GSES) and the EORTC QLQ-C30 were compared between the two groups. Results The scores of self-efficacy before intervention were (30. 41 ± 5. 54) in the observation group and (30. 22 ± 6. 14) in the control group, which had no significant difference (t =0. 241,P >0. 05). The scores of self-efficacy after intervention were (46. 24 ± 5. 33) in the observation group, which was significantly higher than (33. 35 ± 8. 45) in the control group (t=14. 145,P<0. 01). There were no significant differences in the physical function, role function and shortness of breath between the two groups ( t = -0. 985, -1. 314, 0. 238, respectively;P >0. 05). The rest 12 domain of the observation group were significantly better than those in the control group (t=3. 957, -8. 747, -7. 654, 4. 215, 14. 864, 4. 156, -39. 169, 3. 759, 2. 996, 2. 878, 3. 344, 14. 621, respectively;P<0. 05). Conclusions The transitional care program involving group activities can improve the self-efficacy of cervical cancer patients, enhance patients self-management level and the ability to adhere to health behaviors, and improve the quality of life of the patients.

ObjectiveTo understand the status quo of palliative nursing knowledge of medical staff in He'nan Province, analyze its influencing factors and training needs, and provide theoretical basis for further improving palliative nursing knowledge level and formulating effective training measures. Methods? From October 2017 to February 2018, a total of 600 medical staff from six ClassⅢ Grade A hospitals in He'nan Province were selected as the research subjects. All the subjects were investigated with palliative care knowledge questionnaire (PCQN) and the palliative care training needs questionnaire. Multivariate linear regression analysis was used to analyze the influencing factors. A total of 600 questionnaires were sent out and 579 valid questionnaires were collected. Results? The score of PCQN of the 579 medical staff was (12.19±3.221). The factors influencing the knowledge level of palliative care among medical staff were discussed with dying patients or their families, heard of palliative care, educational level, professional title and experience of palliative care, which could explain 37.8% of the total variation of the factors. Conclusions? The knowledge level of palliative care among medical staff is generally low. The factors influencing the knowledge level of palliative care among medical staff were discussed with dying patients or their families, heard of palliative care, educational level, professional title and experience of palliative care. Medical staff have strong training needs in all aspects of palliative care. It is particularly important to train palliative nursing knowledge in relevant specialties.

Objective To extract and summarize the best evidence of manual rehabilitation therapy in patients with breast cancer related lymphedema.It aims to provide evidence-based basis for clinical nursing staff interven-tion.Methods According to the"6S evidence resource pyramid model",we systematically retrieved from UpTo-Date,BMJ best clinical practice,JBI evidence-based medicine center database of Joanna Briggs Institute in Australi-a,Embase,Cochrane Library,Pubmed,GIN,New Zealand Guidelines collaboration group,SIGN,American Cancer So-ciety,American Association for Physical Therapy,American Society for Lymphatic,American Lymphedema Website,Ontario Association of Registered Nurses of Canada,Yimaitong,CNKI,VIP,CBM,WanFang,CHINAL,Web of Science and OVID databases from establishment of database to January 2023.It mainly includes guidelines,consensuses,evi-dence summaries,clinical decision-making,systematic evaluation and primitive research.There were 2 researchers who independently evaluated the quality of the literature and extracted evidence.Results A total of 19 pieces of the literature were involved,including 4 guidelines,4 consensuses,3 system reviews,1 recommended practice,2 clinical decision-making,1 summary of evidence,4 primitive research.Finally,26 pieces of best evidence are summarized from the 5 aspects of indications,contraindications,treatment points,treatment effects and precautions of manual re-habilitation.Conclusion This study summarized the evidence of manual rehabilitation therapy in breast cancer re-lated lymphedema.It can provide practical basis for clinical nursing staff.In clinical practice,it is important to strictly evaluate whether patients have contraindications to treatment,to follow the recommended treatment plan and monitor complications during treatment.