1.Clinical analysis of Korean adult patients with acute pharmaceutical drug poisoning who visited the emergency department
Changyeob LEE ; Sunpyo KIM ; Sun Hyu KIM ; Gyu Chong CHO ; Ji Hwan LEE ; Eun Jung PARK ; Duk Hee LEE
Journal of the Korean Society of Emergency Medicine 2022;33(4):388-396
Objective:
This study classified patients with acute pharmaceutical drug poisoning who visited the emergency department (ED) to identify clinical characteristics that could be used as the foundation for poisoning prevention programs.
Methods:
Adult patients aged ≥19 years who visited one of the 23 EDs in South Korea between 2011 and 2018 with pharmaceutical drug poisoning were analyzed retrospectively by sex. The data were sourced from in-depth survey data and the ED patient surveillance system managed by the Korea Disease Control and Prevention Agency.
Results:
A total of 21,620 cases were analyzed. The sample had more female cases, 15,057 (69.6%); the mean age was 48.3±18.7 years for men and 44.7±17.2 years for women. The onset time was mostly between 18:00 and 24:00 hours; most patients visited the ED via 119 or private vehicles; 5,498 (83.8%) men and 13,070 (86.8%) women reported intentional poisoning; the cause being an intention to commit suicide, though most patients had no history of previous suicide attempts. The frequency of intensive care unit admission and mortality were higher in males than females. When a comparison of the type of drug by sex was carried out, it was observed that analgesic and anti-inflammatory drug poisoning were more frequent in females. On the other hand, cardiovascular drug poisoning was more frequent in males.
Conclusion
There were more women than men among patients with pharmaceutical drug poisoning. Severity was found to be higher in men than women. In most cases, the poisoning was intentional, and the cause of poisoning was a suicide attempt. Sedatives and antipsychotic drugs were the most commonly used drugs in both groups.
2.Far-infrared rays enhance mitochondrial biogenesis and GLUT3 expression under low glucose conditions in rat skeletal muscle cells
Yelim SEO ; Young-Won KIM ; Donghee LEE ; Donghyeon KIM ; Kyoungseo KIM ; Taewoo KIM ; Changyeob BAEK ; Yerim LEE ; Junhyeok LEE ; Hosung LEE ; Geonwoo JANG ; Wonyeong JEONG ; Junho CHOI ; Doegeun HWANG ; Jung Soo SUH ; Sun-Woo KIM ; Hyoung Kyu KIM ; Jin HAN ; Hyoweon BANG ; Jung-Ha KIM ; Tong ZHOU ; Jae-Hong KO
The Korean Journal of Physiology and Pharmacology 2021;25(2):167-175
Far-infrared rays (FIR) are known to have various effects on atoms and molecular structures within cells owing to their radiation and vibration frequencies. The present study examined the effects of FIR on gene expression related to glucose transport through microarray analysis in rat skeletal muscle cells, as well as on mitochondrial biogenesis, at high and low glucose conditions. FIR were emitted from a bio-active material coated fabric (BMCF). L6 cells were treated with 30% BMCF for 24 h in medium containing 25 or 5.5 mM glucose, and changes in the expression of glucose transporter genes were determined. The expression of GLUT3 (Slc2a3) increased 2.0-fold (p < 0.05) under 5.5 mM glucose and 30% BMCF. In addition, mitochondrial oxygen consumption and membrane potential (ΔΨm) increased 1.5- and 3.4-fold (p < 0.05 and p < 0.001), respectively, but no significant change in expression of Pgc-1a, a regulator of mitochondrial biogenesis, was observed in 24 h. To analyze the relationship between GLUT3 expression and mitochondrial biogenesis under FIR, GLUT3 was down-modulated by siRNA for 72 h. As a result, the ΔΨm of the GLUT3 siRNA-treated cells increased 3.0-fold (p < 0.001), whereas that of the control group increased 4.6-fold (p < 0.001). Moreover, Pgc-1a expression increased upon 30% BMCF treatment for 72 h; an effect that was more pronounced in the presence of GLUT3. These results suggest that FIR may hold therapeutic potential for improving glucose metabolism and mitochondrial function in metabolic diseases associated with insufficient glucose supply, such as type 2 diabetes.
3.Far-infrared rays enhance mitochondrial biogenesis and GLUT3 expression under low glucose conditions in rat skeletal muscle cells
Yelim SEO ; Young-Won KIM ; Donghee LEE ; Donghyeon KIM ; Kyoungseo KIM ; Taewoo KIM ; Changyeob BAEK ; Yerim LEE ; Junhyeok LEE ; Hosung LEE ; Geonwoo JANG ; Wonyeong JEONG ; Junho CHOI ; Doegeun HWANG ; Jung Soo SUH ; Sun-Woo KIM ; Hyoung Kyu KIM ; Jin HAN ; Hyoweon BANG ; Jung-Ha KIM ; Tong ZHOU ; Jae-Hong KO
The Korean Journal of Physiology and Pharmacology 2021;25(2):167-175
Far-infrared rays (FIR) are known to have various effects on atoms and molecular structures within cells owing to their radiation and vibration frequencies. The present study examined the effects of FIR on gene expression related to glucose transport through microarray analysis in rat skeletal muscle cells, as well as on mitochondrial biogenesis, at high and low glucose conditions. FIR were emitted from a bio-active material coated fabric (BMCF). L6 cells were treated with 30% BMCF for 24 h in medium containing 25 or 5.5 mM glucose, and changes in the expression of glucose transporter genes were determined. The expression of GLUT3 (Slc2a3) increased 2.0-fold (p < 0.05) under 5.5 mM glucose and 30% BMCF. In addition, mitochondrial oxygen consumption and membrane potential (ΔΨm) increased 1.5- and 3.4-fold (p < 0.05 and p < 0.001), respectively, but no significant change in expression of Pgc-1a, a regulator of mitochondrial biogenesis, was observed in 24 h. To analyze the relationship between GLUT3 expression and mitochondrial biogenesis under FIR, GLUT3 was down-modulated by siRNA for 72 h. As a result, the ΔΨm of the GLUT3 siRNA-treated cells increased 3.0-fold (p < 0.001), whereas that of the control group increased 4.6-fold (p < 0.001). Moreover, Pgc-1a expression increased upon 30% BMCF treatment for 72 h; an effect that was more pronounced in the presence of GLUT3. These results suggest that FIR may hold therapeutic potential for improving glucose metabolism and mitochondrial function in metabolic diseases associated with insufficient glucose supply, such as type 2 diabetes.