1.Differential expression profiles of microRNAs/mRNA and docking study in oral squamous cell carcinoma.
Siyu LIU ; Long XIE ; Bing QI ; Changyan MA ; Lei SANG ; Hongwei LI
West China Journal of Stomatology 2014;32(4):400-403
OBJECTIVETo construct and analyze the differential expression profiles of microRNAs (miRNA) and mRNA in oral squamous cell carcinoma (OSCC). To explore the miRNA and mRNA of OSCC development and progression.
METHODSThe differential expression profiles of miRNA and mRNA were built by high-throughput deep sequencing technology. Using Gene Ontology (GO) enrichment analysis, the roles of differentially expressed miRNA and mRNA in cell cycle, cell proliferation, cell differentiation and cell apoptosis were analyzed.
RESULTSSeventy-seven differentially expressed miRNA and 1 298 differentially expressed mRNAs were identified in OSCC. GO analysis showed that 73 miRNA had found target mRNA in cell cycle, cell proliferation, cell differentiation and cell apoptosis of OSCC. Moreover, a miRNA could regulate multiple mRNA.
CONCLUSIONThe differential expression profiles of miRNA and mRNA have close relationship with the development and progression of OSCC.
Apoptosis ; Carcinoma, Squamous Cell ; Cell Proliferation ; Gene Expression Regulation, Neoplastic ; Humans ; MicroRNAs ; Mouth Neoplasms ; RNA, Messenger
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