1.Analysis of the unqualified HCV detection results of blood donors from the served area of 22 domestic blood institutions
Zhongsi YANG ; Shouguang XU ; Wei ZHANG ; Jian ZHANG ; Xiaojie LIU ; Feng YANG ; Qin WANG ; Yanqin HE ; Lin BAO ; Zhiqiang YU ; Zhenxing WANG ; Changwen QIU ; Xiaobo CAI ; Li LI ; Peng WANG ; Zhanfeng XU ; Furong YU ; Chao ZHAO ; Jiankang WANG ; Youhua SHEN ; Jingjing BAO ; Jun ZHOU ; Yan QIU
Chinese Journal of Experimental and Clinical Virology 2023;37(4):367-372
Objective:To investigate the unqualified hepatitis C virus (HCV) detection result of blood donors from the served area of blood institutions.Methods:The data related to HCV markers detected of the first and repeat blood donors were collected from the system of practice comparison for the Chinese mainland blood institutions from 2017 to 2021. The anti-HCV reactive rate and the rates of anti-HCV negative but HCV-RNA reaction and all the relationship between rates and the annual, regional and different blood donors were statistically analyzed.Results:During 2017-2021, the number of anti-HCV reactive per 100 000 blood donors decreased from 444.3 to 250.44 in the served area of 22 blood institutions ( χ2=49.677, P<0.05). The number of HCV RNA detected positive per 100 000 anti-HCV negative increased from 0.69 to 2.05 year by year, but there was no statistical significance ( χ2=0.643, P>0.05). The anti-HCV unqualified rate was significantly different among regions ( χ2=3 260.283, P<0.05). The anti-HCV unqualified rate of the first blood donors was significantly higher than that of the repeated blood donors ( F=130.993, P < 0.05). The annual number of HCV RNA detected positive per 100 000 anti-HCV negative blood samples from donors ranged from 0 to 17.28. Conclusions:The anti-HCV unqualified rate of blood donors in the served area of 22 blood institutions decreased year by year. Compared with repeated blood donors, HCV infection should be emphasized in first-time blood donors. The implementation of HCV RNA test can detect out much more HCV infections and reduce the risk of transfusion transmitted infectious HCV.
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