PURPOSE: The early parity that reduces the risk of developing breast cancer indicates that hormonal conditions might play an important role in its prevention. Both pregnancy and hCG treatment are considered essential for the inhibiting breast cancer. The purpose of this study is to investigate the incidence of beta-hCG expression in breast cancer and to access its relationship with the other biologic parameters. METHODS: Three hundred and thirty-four cases of formalin-fixed, paraffin embedded tissue blocks were selected, and then immunostained for beta-hCG. HCG expression was compared with ER, PR, HER-2/neu, the tumor characteristics and recurrence. RESULTS: Forty-four cases (13.2%) showed positivity for beta-hCG. HCG positivity was observed in 12.0% of infiltrating ductal carcinomas (32/267), 13.3% of intraductal carcinomas (4/30), 11.1% of infiltrating lobular carcinomas (1/9), 80.0% of apocrine carcinomas (4/5) and 13.0% of the other types of carcinomas (3/23). HCG expression was statistically significant between the histological tumor types (p=0.001), but not with the patient's age (p=0.696), tumor grade (p=0.255), tumor size (p=0.510), lymph node status (p=0.620), ER (p=0.498), PR (p=0.421), HER-2/neu oncogene expression (p=0.483) and tumor recurrence (p=0.181). HCG was focally expressed in the cytoplasm of the conventional types, but the apocrine type displayed diffusely intense cytoplasmic staining. CONCLUSION: Although beta-hCG expression was statistically insignificant between the tumor recurrence (p=0.181) and biological parameters, it may be of interest in the future to correlate the presence of beta-hCG expression with a possible therapeutic response in patients of the breast cancer.
Breast Neoplasms* ; Breast* ; Carcinoma, Ductal ; Carcinoma, Intraductal, Noninfiltrating ; Carcinoma, Lobular ; Chorion* ; Cytoplasm ; Female ; Humans* ; Immunohistochemistry ; Incidence ; Lymph Nodes ; Oncogenes ; Paraffin ; Parity ; Pregnancy ; Prognosis ; Recurrence

PURPOSE: The purpose of this study was to investigate the relationship between cell phone dependency and aggression in elementary school students with the mediating effect of leisure activities in South Korea. METHODS: Data were cross-sectional in study design with 1,555 fourth grade elementary school students participating in the 4th-year Korean Children and Youth Panel Survey. Data analysis was performed using the SPSS/WIN 23.0 and AMOS 21.0 program. RESULTS: Cell phone dependency has a significant effect on aggression, but it did not act as a control variable in the relationship between the protective factor, weekly book reading time and the amount of daytime play with aggression. Weekly entertainment time and weekly TV and video viewing time had a significant statistical effect on aggression, thus this study confirmed that cell phone dependency acts as a control variable in relation to aggression. CONCLUSION: As the entertainment time for elementary school students, the time spent watching TV and videos play a negative role, it is necessary to prepare a leisure activity management practice and strategies with an emphasis on entertainment time as well as, TV and video viewing as elementary school students' leisure activities for a healthy school life.
Adolescent ; Aggression ; Cell Phones ; Child ; Dependency (Psychology) ; Humans ; Korea ; Leisure Activities ; Negotiating ; Protective Factors ; Statistics as Topic

Periductal mastitis and mammary duct ectasia are now considered as separate disease entities in the female breast, and these two diseases affect different age groups and have different etiologies and clinical symptoms. These two entities have very rarely been reported in the male breast and they have long been considered as the same disease as that in the female breast without any differentiation. We report here on the radiologic findings of a rare case of periductal mastitis that developed during the course of chemotherapy for lung cancer in a 50-year-old male. On ultrasonography, there was a partially defined mass with adjacent duct dilatation and intraductal hypoechogenicity, and this correlated with an immature abscess with a pus-filled, dilated duct and periductal inflammation on the pathologic examination.
Abscess ; Breast* ; Dilatation ; Dilatation, Pathologic ; Drug Therapy ; Female ; Humans ; Inflammation ; Lung Neoplasms ; Male* ; Mastitis* ; Middle Aged ; Ultrasonography

Periductal mastitis and mammary duct ectasia are now considered as separate disease entities in the female breast, and these two diseases affect different age groups and have different etiologies and clinical symptoms. These two entities have very rarely been reported in the male breast and they have long been considered as the same disease as that in the female breast without any differentiation. We report here on the radiologic findings of a rare case of periductal mastitis that developed during the course of chemotherapy for lung cancer in a 50-year-old male. On ultrasonography, there was a partially defined mass with adjacent duct dilatation and intraductal hypoechogenicity, and this correlated with an immature abscess with a pus-filled, dilated duct and periductal inflammation on the pathologic examination.
Abscess ; Breast* ; Dilatation ; Dilatation, Pathologic ; Drug Therapy ; Female ; Humans ; Inflammation ; Lung Neoplasms ; Male* ; Mastitis* ; Middle Aged ; Ultrasonography