Objective To decrease the fault rate and increase the clinical application management of the defibrillator.Methods The allocation,training,daily maintenance,quality control,emergency treatment and etc of the defibrillators in some hospital were summarized,and a set of clinical application management method was proposed for the defibrillators.Results The allocation and maintenance of the defibrillators were improved,and the rate for the completion of records reached 100％.The fault rate of the defibrillators was 0,and A requirements for first-aid and life support devices in grade assessment issues were fulfilled.Conclusion It's proved the management method is feasible for eliminating the deficiencies in clinical application management of the defibrillator.