1.Cyclosporin A in High Risk Penetrating Keratoplasty.
Journal of the Korean Ophthalmological Society 2001;42(8):1139-1142
PURPOSE: To conform the effectiveness of Cyclosporin(CsA) in penetrating keratoplasty(PKP), we compared the survival rate of grafts between CsA-used group and CsA-unused group(control group) in high risk patients. MATERIAL AND METHOD: High risk cornea was defined as vascularization in 3 or 4 quadrants, recurrent graft or corneal surface disease. We reviewed the 74 eyes(74 patients) which received penetrating keratoplasty with high risk cornea, and compared the survival rate between CsA-used group and control group. RESULT: Twenty-nine of the 74 patients were treated with CsA(17 patients with topical CsA and 12 with oral CsA ). The survival rate of CsA-used group was not superior to that of control group. CONCLUSION: CsA seems not to be effective in graft survival of high risk PKP.
Cornea
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Cyclosporine*
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Graft Survival
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Humans
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Keratoplasty, Penetrating*
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Survival Rate
;
Transplants
2.Erratum: Bone regeneration of mouse critical-sized calvarial defects with human mesenchymal stem cells in scaffold.
Jin Young IM ; Woo Kie MIN ; Changkook YOU ; Hyun Ok KIM ; Hee Kyung JIN ; Jae sung BAE
Laboratory Animal Research 2014;30(1):44-44
At the request of the authors, the Acknowledgments information has been changed.
3.Bone regeneration of mouse critical-sized calvarial defects with human mesenchymal stem cells in scaffold.
Jin Young IM ; Woo Kie MIN ; Changkook YOU ; Hyun Ok KIM ; Hee Kyung JIN ; Jae Sung BAE
Laboratory Animal Research 2013;29(4):196-203
Combination of tissue engineering and cell therapy represents a promising approach for bone regeneration. Human mesenchymal stem cells (hMSCs) have properties that include low immunogenicity, high proliferation rate, and multi-differentiation potential; therefore, they are an attractive seeding source for tissue engineering therapy. Here we found that hMSCs with a scaffold did not affect cell viability and osteogenic differentiation. We also investigated regenerative effect of hMSCs with the scaffold in a calvarial bone defect model. Formation of new bone was evaluated by micro-CT, histology and expression of osteogenic markers. The results clearly showed interesting evidence indicating that hMSCs with scaffold increased the formation of new bone and expression of osteogenic markers, compared to the empty and scaffold only groups. Overall, our results suggest that hMSCs with scaffold are suitable for stimulation of intense bone regeneration in critical-sized bone defects.
Animals
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Bone Regeneration*
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Cell Survival
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Humans*
;
Mesenchymal Stromal Cells*
;
Mice*
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Tissue Engineering
;
Tissue Therapy
Result Analysis
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